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胃癌 組織의 Lysozyme, Carcinoembryonic Antigen 및 Keratin에 對한 免疫 組織 化學的 硏究
이혜수,허장호,최호열 의과학연구소 1991 全北醫大論文集 Vol.15 No.1
Gastric cancer is the most common tumor in Korean. To investigate the significance of the immunohistochemical study using a immunoperoxidase technics on the formalin fixed, paraffin embedded section of the gastric cancer tissues, peroxidase-antiperoxidase stain for lyso- zyme, carcinoemvbryonic antigen(CEA) and keratin were carried out on the 68 cases of the gastric cancer of 27 cases of well differentiated adenocarcinoma, 14 cases of moderate differentiated adenocarcinoma, 22 cases of poorly differentated adenocarcinoma and 5 cases of the signer ring cell carcinoma, and 21 cases of the no- rmal gastric tissues. The results were as follows. 1. Rate of the positivity of the lysozyme on the gastric cancer was 69.1%(47/68). And rate and degree of the positivity was markedly decreased in the poorty differentiated adenocarcinoma compared with well differe- ntiated adenocarcinoma. 2. In the stain for the carcinoembryonic antigen, the rate of positivity was 83%(59/68), and moderate to st- rong positive reactions were shown independent of its differentiation. 3. Keratin in the normal and all gastric cancer tissues was not demonstrated. Above results suggest that detection of the lysozyme and carcinoembryonic antigen using a peroxidase-anti- peroxidase method are helpful to the diagnosis of the degree of differentiation of gastric cancer tissues.
방지영,허장호,나지운,Qiao Lu,Bradley A. Carlson,Ryuta Tobe,Petra A. Tsuji,Vadim N. Gladyshev,Dolph L. Hatfield,이병재 한국분자세포생물학회 2015 Molecules and cells Vol.38 No.5
The 15-kDa selenoprotein (Sep15) is a selenoprotein residing in the lumen of the endoplasmic reticulum (ER) and implicated in quality control of protein folding. Herein, we established an inducible RNAi cell line that targets Sep15 mRNA in Chang liver cells. RNAi-induced Sep15 deficiency led to inhibition of cell proliferation, whereas cell growth was resumed after removal of the knockdown inducer. Sep15-deficient cells were arrested at the G1 phase by upregulating p21 and p27, and these cells were also characterized by ER stress. In addition, Sep15 deficiency led to the relocation of focal adhesions to the periphery of the cell basement and to the decrease of the migratory and invasive ability. All these changes were reversible depending on Sep15 status. Rescuing the knockdown state by expressing a silent mutant Sep15 mRNA that is resistant to siRNA also reversed the phenotypic changes. Our results suggest that SEP15 plays important roles in the regulation of the G1 phase during the cell cycle as well as in cell motility in Chang liver cells, and that this selenoprotein offers a novel functional link between the cell cycle and cell motility.