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한병훈(Byung Hoon Han),윤혜숙(Hye Sook Yun Choi),정성현(Sung Hyun Chung) 한국생약학회 1981 생약학회지 Vol.12 No.1
Twenty-seven medicinal plants were selected on the basis of folkloric reputation for the treatment of hypertension or related deseases. Two solvent fractions were prepared from methanol extract of each plant and tested for their effects on angiotensin converting enzyme (ACE) activities. Six solvent fractions showed more than 50% inhibition and four showed 40∼50% inhibition at the conditions tested.
수종의 페니실린들이 안지오텐신 변화효소 활성에 미치는 영향
윤혜숙,정성현,한병훈 ( Hye Sook Yun ( Choi ),Sung Hyun Chung,Byung Hoon Han ) 생화학분자생물학회 1982 BMB Reports Vol.15 No.2
Thirteen different penicillins and cephalosporins were tested against the activities of angiotensin converting enzyme(ACE). Pivampicillin and talampicillin showed mild inhibitory activities against ACE. The inhibitory activities were confirmed by observing that pivampicillin and talampicillin inhibited the contractions induced by angiotensin I but not the contractions by angiotensin II on isolated rat ileum. Penicillins and cephalosporins cephalosporins have some resemblance on their chemical structure to captopril, one of the most potent inhibitory of ACE. However, the result showed that the overall structure of penicillins and cephalosporins are unfavorable for the compounds to be inhibitory to ACE. On the other hand, esterification of the free acid resulted in increase the inhibitory activities.