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      • KCI등재

        한국 소아에서 흰살생선 알레르기: 단일기관 후향적 연구

        염상화,프레브산,박그믐,정경욱,이수영 대한 소아알레르기 호흡기학회 2024 Allergy Asthma & Respiratory Disease Vol.12 No.2

        . Purpose: Fish allergy is rare in children, and there have been few studies on childhood fish allergy. This study aims to investigate the clinical characteristics and laboratory findings of white meat fish (WMF) allergy in Korean children. Methods: In this study, we enrolled 150 children with a history of WMF consumption who underwent serum specific immunoglobulin E to cod (cod-sIgE) at Ajou University Hospital from January 2019 to December 2022. The demographic characteristics, clinical symptoms, history of consuming 6 major Korean WMF (cod, cutlass, yellow croaker, brown sole, olive flounder, and anchovy), and cod-sIgE were investigated. Results: Sixty-five subjects (43.3%) had clinical responses to at least 1 of the 6 WMF (WMF-allergic), and 85 subjects had no allergic reaction to all 6 WMF (WMF-tolerant). The median age of first symptom onset in the WMF-allergic group was 15 months. Major causative WMF were yellow croaker (30.6%), cutlass (28.7%), cod (26.1%), brown sole (20.4%), anchovy (14.7%), and olive flounder (6.5%). Twenty-three of 65 WMF-allergic children (35.4%) had anaphylaxis. The median level of cod-sIgE was 4.61 kUA/L (range, 0.04–100.10 kUA/L) in the WMF-allergic group, and this value was significantly higher (P<0.001) than that of the WMF-tolerant group (0.04 kUA/L; range, 0.04–3.08 kUA/L). The positive rates (≥class 2, 0.7 kUA/L) of cod-sIgE for the 6 individual WMF ranged from 69% to 90%. Conclusion: We propose that WMF allergy can develop in young children, with 35.4% experiencing anaphylaxis. Cod-sIgE is considered a useful tool for diagnosing not only cod allergy but also other WMF allergy in children.

      • KCI등재

        소아 들깨알레르기에서 참깨 동시 감작과 교차반응성 연구

        김혜보 ( Hyebo Kim ),프레브산 ( Purevsan Gantulga ),이은주 ( Eunjoo Lee ),이정민 ( Jeongmin Lee ),이수영 ( Sooyoung Lee ),정경욱 ( Kyunguk Jeong ) 대한천식알레르기학회 2022 Allergy Asthma & Respiratory Disease Vol.10 No.2

        Purpose: Perilla seed (PS) is the most common cause of seed-induced anaphylaxis in Korean children, but the reports on PS allergy, including phenotype and cross-reactivity, are rare. The aim of this study is to assess the clinical characteristics of PS allergy and investigate cross-reactivity with sesame seed (SS). Methods: Through a retrospective medical record review, patients with clinical PS allergy were identified in a single tertiary hospital. Clinical characteristics of allergic reaction upon exposure to PS and SS, results of skin prick test (SPT) to PS and SS, and the levels of serum SS-specific immunoglobulin E (SS-sIgE) were investigated. Cross-reactivity between PS and SS was studied using IgE enzyme-linked immunosorbent assay (ELISA) inhibition. Results: The median age of 34 PS-allergic children was 41.5 months (range, 10 months to 12 years), and the proportion of anaphylaxis upon exposure to PS was 29.4% (n=10). The PS SPT was positive in 94.1% (n=32) with the median wheal size of 6.25 mm. Among PS-allergic children, the percentages of patients with positive symptoms, negative symptoms, and indeterminate symptoms upon exposure to SS were 8.8%, 41.2%, and 50%, respectively. Out of 14 PS-allergic children who were tolerant to SS, positive sensitization to SS was noticed in 78.6% by serum SS-sIgE, and 57.1% by SS SPT. Partial cross-reactivity between PS and SS was identified in IgE ELISA inhibition. Conclusion: This study reported the clinical profiles and SPT results in a relatively large number of PS-allergic children and identified the partial cross-reactivity between PS and SS for the first time. (Allergy Asthma Respir Dis 2022;10:110-117)

      • KCI등재

        한국 소아에서 흰살생선 알레르기: 단일기관 후향적 연구

        염상화 ( Sanghwa Youm ),프레브산 ( Purevsan Gantulga ),박그믐 ( Geu-meum Park ),정경욱 ( Kyunguk Jeong ),이수영 ( Sooyoung Lee ) 대한천식알레르기학회 2024 Allergy Asthma & Respiratory Disease Vol.12 No.2

        Purpose: Fish allergy is rare in children, and there have been few studies on childhood fish allergy. This study aims to investigate the clinical characteristics and laboratory findings of white meat fish (WMF) allergy in Korean children. Methods: In this study, we enrolled 150 children with a history of WMF consumption who underwent serum specific immunoglobulin E to cod (cod-sIgE) at Ajou University Hospital from January 2019 to December 2022. The demographic characteristics, clinical symptoms, history of consuming 6 major Korean WMF (cod, cutlass, yellow croaker, brown sole, olive flounder, and anchovy), and cod-sIgE were investigated. Results: Sixty-five subjects (43.3%) had clinical responses to at least 1 of the 6 WMF (WMF-allergic), and 85 subjects had no allergic reaction to all 6 WMF (WMF-tolerant). The median age of first symptom onset in the WMF-allergic group was 15 months. Major causative WMF were yellow croaker (30.6%), cutlass (28.7%), cod (26.1%), brown sole (20.4%), anchovy (14.7%), and olive flounder (6.5%). Twenty-three of 65 WMF-allergic children (35.4%) had anaphylaxis. The median level of cod-sIgE was 4.61 kU<sub>A</sub>/L (range, 0.04-100.10 kU<sub>A</sub>/L) in the WMF-allergic group, and this value was significantly higher (P<0.001) than that of the WMF-tolerant group (0.04 kU<sub>A</sub>/L; range, 0.04-3.08 kU<sub>A</sub>/L). The positive rates (≥class 2, 0.7 kU<sub>A</sub>/L) of cod-sIgE for the 6 individual WMF ranged from 69% to 90%. Conclusion: We propose that WMF allergy can develop in young children, with 35.4% experiencing anaphylaxis. Cod-sIgE is considered a useful tool for diagnosing not only cod allergy but also other WMF allergy in children. (Allergy Asthma Respir Dis 2024;12:72-77)

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