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Preparation and Determination of Structure of L-3-Deoxymimosine-containing Peptides
Chae, Whigun,Lee, Eung-Seok 영남대학교 약품개발연구소 2000 영남대학교 약품개발연구소 연구업적집 Vol.10 No.-
L-3-Deoxymimosine-containing decapeptides were prepared for the development of protein tyrosine kinase(PTK) inhibitors. During the preparation of peptides, several side products were formed. Identification and determination of major peptides generated were reported.
Jeong, Tae Cheon,Lee, Eung-Seok,Chae, Whigun,Koh, Woo Suk,Kang, Boo-Hyon,Han, Sang Seop 영남대학교 약품개발연구소 2002 영남대학교 약품개발연구소 연구업적집 Vol.11 No.-
lmmunotoxic effects of 2-bromopropane were investigated in male Sprague-Dawley rats.The rats were treated orally daily with 2-bromopropane at 100, 330, or 1000 mg/kg for 28 consecutive days. Four days before necropsy, the rats were immunized intravenously with sheep red blood cells (SRBCs). The body and thymus weights were significantly reduced by treatment with 2-bromopropane at the highest dose. In addition, the numbers of splenic and thymic cells were decreased by 2-bromopropane. In hematology, the numbers of white blood cells, red blood cells, and platelets were significantly reduced. Among the serum clinical parameters, the levels of chloride ion were significantly increased by 2-bromopropane. The antibody respose to SRBCs was significantly suppressed at the highest dose. With immunized animals. immunophenotyping of splenic and thymic cells was performed to investigate the changes of the number of macrophages, B cells, and T cells in spleen and the number of CD4^+ and CD8^+ cells in thymus. The numbers of most cell types were significantly decreased in the spleen when animals were treated with 2-bromopropane at 100 mg/kg. Likewise, all cell types of thymus were significantly decreased by 2-bromopropane. The present results suggest that 2-bromopropane may have an immunotoxic potential in male Sprague-Dawley rate when the rats are exposed for 28 d.
Ameliorating Effects of Moxifloxacin on Endotoxin-Induced Acute Lung Injury in Rats
Young Man Lee(이영만),Whi Gun Chae(최휘건) 한국생명과학회 2011 생명과학회지 Vol.21 No.8
흰쥐에서 내독소로 유도된 급성 폐손상에서 moxifloxacin의 효과를 형태학적으로 호중구의 폐장 내 침윤 및 세포질형 포스포리파아제(cytosolic phospholipase A2) 발현과 관련하여 알아보았다. 내독소는 잘 알려진대로 흰쥐에서 급성 폐손상을 유발하였고 이때 폐장 내의 호중구의 침윤 및 폐장 및 호중구에서의 세포질형 포스포리파아제의 발현이 증가하였고, 또한 염증성 사이토카인의 일종인 종양괴사성인자(tumor necrosis factor)의 발현도 증가하였다. 전자현미경을 이용한 산소기 생성의 검사에서도 내독소에 의하여 산소기의 생성이 폐장 내에 증가한 사실을 확인하였고, 산화성 스트레스에 유발되는 제2형 폐포세포에서의 층상체의 변화도 관찰하였다. 면역변환효과가 있다고 알려진 moxifloxacin은 이러한 변화들을 억제하고 형태학적으로 내독소에 의한 급성 폐손상을 현저히 감소시켰다. The immunomodulating effects of moxifloxacin seem to be effective in downregulating inflammatory reactions. This presumed effect was tested in endotoxin (ETX)-induced acute lung injury (ALI) in rats. After moxifloxacin treatment (10 ㎎/㎏) of ETX-given rats, lung myeloperoxidase (MPO) activity, bronchoalveolar-lavage (BAL) protein, and the number of neutrophils in the BAL cells were measured. Light and electron microscopic structures were also examined. Electron microscopic CeCl₃ histochemistry for the detection of hydrogen peroxide in the lungs and immunohistochemistry of cytosolic phospholipase A2 (cPLA2) in the lung tissues and BAL cells were performed. To examine the expression of TNFα in the lungs, western blotting was carried out with the lung tissues. ETX had accumulated neutrophils in the lungs, which was followed by lung leak. Oxidative stress occurred, and increased expression of cPLA2 in the lung tissues and BAL cells was observed in the ETX-given rats. Simultaneously, the expression of TNFα was enhanced by ETX. Moxifloxacin, however, decreased all these parameters, indicating that ALI may have been ameliorated. Moxifloxacin appears to ameliorate ETX-induced ALI partially through the suppression of cPLA2 in the lungs of rats.
Kim, Yong-chul,Zhao, Long-Xuan,Kim, Tae-Hyung,Je, Sun-mi,Kim, Eun-kyung,Choi, Heesung,Chae, Whi-Gun,Park, Minsoo,Choi, Jongwon,Jahng, Yurngdong,Lee, Eung-Seok 영남대학교 약품개발연구소 2000 영남대학교 약품개발연구소 연구업적집 Vol.10 No.-
For the development of new anticonvulsive agents. r-vinyl GABA(vigabatrin) and GABA mimeties derivatives were covalently coupled as potential dual acting prodrugs and evaluated for their anticonvulsive activities. Among the prepared com-pounds. 11 showed the most potent anticonvulsive activity, a shorter onset time and a broader spectrum compared to vigabatrin. ⓒ 2000 Elsevier Science Ltd. All rights reserved.
Synthesis, Characterization and in Vitro Identification of N^7-Guanine Adduct of 2-Bromopropane
Zhao, Long-Xuan,Kim, Eun-Kyung,Lim, Hyun-Tae,Moon, Yoon-Soo,Kim, Nam-Hee,Kim, Tae-Hyung,Choi, Heesung,Chae, Whigun,Jeong, Tae Cheon,Lee, Eung-Seok 영남대학교 약품개발연구소 2002 영남대학교 약품개발연구소 연구업적집 Vol.11 No.-
Recently, we have reported that 2-bromopropane might have an immunotoxic potential in rats when exposed for 28 days. In the present studies, the possibility of 2i-deoxyguanosine adduct formation by 2-bromopropane was investigated in vitro to elucidate molecular mechanism of 2-bromopropane-induced immunosuppression. N^7-Guanine adduct of 2'-bromopropane (i.e., N^7-isopropyl guanine) was chemically synthesized and structurally characlerized by analysis of UV, ^H-NMR, ^12C-NMR, COSY and fast atom bombardment, mass spectrometry to use as a reference material. Incubation of 2'-deoxyguanosine with an excess amount of 2-bromopropane in PBS buffer solution, pH 7.4, AT 37℃ for 16 h, followed by a thermal hydrolysis, produced a detectable amount of N^7-isopropyl guanine by an HPLC and UV analysis. The present results suggest that 2-bromopropane might form a DNA adduct in N^7 position of 2'-deoxyguanosine at a physiological condition.
연구논문 : 생명과학 ; 2-Bromopropane과 1,2-dibromopropane을 마우스에 단희투여시 유발되는 간독성과 면역독성의 특성에 관한 연구
김남희 ( Nam Hee Kim ),현선희 ( Sun Hee Hyun ),김춘화 ( Chun Hua Jin ),이상규 ( Sang Kyu Lee ),이동욱 ( Dong Wook Lee ),전태원 ( Tae Won Jeon ),최창본 ( Chang Bon Choi ),이응석 ( Eung Seok Lee ),최휘건 ( Whi Gun Chae ),정태천 ( Ta 영남대학교 약품개발연구소 2004 영남대학교 약품개발연구소 연구업적집 Vol.14 No.-