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최인희(Choi, Inhee),서재영(Seo, Jaeyoung) 한국열린교육학회 2021 열린교육연구 Vol.29 No.6
본 연구에서는 「한국교육종단연구2005」 자료를 활용하여 대학원생의 연구효능감에 영향을 미친 요인을 탐색하였다. 대학원생의 연구효능감에 영향을 미칠 것으로 예상되는 변인으로 학생 개인의 특징을 나타내는 성별과 자아개념, 대학에서의 경험을 나타내는 대학학점, 대학적응, 만족도를 포함하였다. 또한 대학원에서의 전공계열, 프로젝트 참여 여부, 대학원 전공 교과목의 도움 정도, 대학원 전공여건 만족도, 지도교수 연구멘토링을 대학원에서의 경험을 나타내는 독립변인으로 설정하였다. 다중회귀분석을 실시한 결과, 자아개념, 대학적응은 대학원생의 연구효능감에 정적인 영향을 미치는 요인으로 분석되었다. 또한 대학원 교육여건 만족도와 지도교수의 연구멘토링 중 대학원생이 독립적인 연구자로 성장할 수 있도록 지원하는 성장중심 멘토링이 연구효능감을 높이는 요인으로 나타났다. 마지막으로 이공계에서는 프로젝트 참여에 따른 연구효능감 차이가 없었지만, 비이공계에서는 프로젝트 참여 경험이 연구효능감에 정적인 영향을 미치는 요인으로 나타나, 전공계열별로 프로젝트 참여에 따른 효과에 차이가 있는 것으로 나타났다. In this study, the factors affecting the research self-efficacy of graduate students were analyzed using KELS 2005 data. Variables expected to affect the research self-efficacy of graduate students, such as: gender and self-concept, which represent individual characteristics, college credits, college adaptation, and satisfaction, which represent university experiences, were included. In addition, the major, project participation, the degree to which graduate major courses were helpful, satisfaction with graduate school environment, and research mentoring by academic advisors were set as independent variables indicating the experience while attending graduate school. As a result of multiple regression analysis, self-concept and university adaptation had a positive influence on the research self-efficacy of graduate students. Among the research mentoring of their advisors, growth-focused mentoring, which supports graduate students to grow as independent researchers, positively affected research self-efficacy. Lastly, there was no difference in research self-efficacy according to project participation for science and engineering graduate students, but for non-science and engineering graduate students, project participation experiences had a positive effect on research self-efficacy.
플라즈몬 나노 입자의 광학적 특성을 활용한 세포 노화 측정에 대한 수치적 연구
김윤(Yun Kim),안현지(Hyun-Ji An),최인희(Inhee Choi),송지환(Jihwan Song) 대한기계학회 2021 대한기계학회 춘추학술대회 Vol.2021 No.8
As the cells are senescent, the topology of the chromatin in the cell changes. Histones, which are located at the chromatin, also change their distribution according to the topological change of chromatin. The topology of chromatin can be analyzed by attaching detectable substances to the histones. Conventional methods, such as using fluorescent dyes, have disadvantages in the analysis of the histone distribution including the arrangements and distances because they only can provide blurred images. Plasmonic particles (e.g., Au and Ag) can be adopted to overcome these drawbacks. They show distinct optical characteristics when their arrangements and distances are varied. Herein, we studied the distinct optical properties according to the varying inter-particle distance, arrangements, and number through computational simulation. In addition, the distributions of the histones were predicted in comparison with the experimental results. We believe this method which can provide more clear information including inter-particle distance and their arrangements will help monitor the progress of the diseases or senescence.
초발수성 마이크로 포어에서 액적 충돌 기반의 마이크로 액적 생성
전병은(Byeongeun Jeon),고영수(Youngsu Ko),최인희(Inhee Choi),허윤정(Yunjung Heo),이충엽(Choongyeop Lee) 대한기계학회 2022 대한기계학회 춘추학술대회 Vol.2022 No.11
When an aqueous liquid drop is impinged on a superhydrophobic porous surface, the liquid penetration may occur in the form of a liquid jet or micro droplets depending on an impact velocity. Here by impacting a liquid drop on a superhydrophobic surface with a single micro pore, we demonstrate that it is possible to dispense a single micro drop of a controlled size in a reproducible way, while proposing the impact condition (i.e., impact velocity) under which a single micro droplet is generated, as a function of a micro pore size and a liquid viscosity. It is found that a larger impact velocity is required to generate a single micro drop as a micro pore size decreases, while an impact velocity for a single micro drop generation appears to be rather insensitive to the liquid viscosity. Also, the diameter of micro drop is found to be roughly 1.5 times of the diameter of micro pore for all tested pore sizes, such that about 75 μm-diameter micro droplet is obtained with a 50 μm-diameter micro pore. As an application example, we demonstrate the successful printing of an array of micro droplets on a paper. We believe that the present approach can be a simple and effective strategy to micro droplet printing without the typical issues associated with droplet printing, such as clogging or satellite droplet generation.
초발수성 마이크로 포어에서 액적 충돌 기반의 마이크로 액적 생성
전병은(Byeongeun Jeon),고영수(Youngsu Ko),최인희(Inhee Choi),허윤정(Yunjung Heo),이충엽(Choongyeop Lee) 대한기계학회 2022 대한기계학회 춘추학술대회 Vol.2022 No.11
When an aqueous liquid drop is impinged on a superhydrophobic porous surface, the liquid penetration may occur in the form of a liquid jet or micro droplets depending on an impact velocity. Here by impacting a liquid drop on a superhydrophobic surface with a single micro pore, we demonstrate that it is possible to dispense a single micro drop of a controlled size in a reproducible way, while proposing the impact condition (i.e., impact velocity) under which a single micro droplet is generated, as a function of a micro pore size and a liquid viscosity. It is found that a larger impact velocity is required to generate a single micro drop as a micro pore size decreases, while an impact velocity for a single micro drop generation appears to be rather insensitive to the liquid viscosity. Also, the diameter of micro drop is found to be roughly 1.5 times of the diameter of micro pore for all tested pore sizes, such that about 75 μm-diameter micro droplet is obtained with a 50 μm-diameter micro pore. As an application example, we demonstrate the successful printing of an array of micro droplets on a paper. We believe that the present approach can be a simple and effective strategy to micro droplet printing without the typical issues associated with droplet printing, such as clogging or satellite droplet generation.
Dihydrofolate Reductase-저해제 복합체에 대한 X-선 결정체 구조와 docking model의 구조 비교
안미현,최인희,김춘미 梨花女子大學校 藥學硏究所 2002 藥學硏究論文集 Vol.- No.11
A comparative study to validate the reliability of a fully automated docking program, FlexiDock, was carriedout to predict the binding modes of DHFR-inhibitor complex. The inhibitors were extracted from the crystallographicallydetermined DHFR-NADP^+(H)-inhibitor ternary complexes of human, Escherichia coli and Candida albicans and thendocked back into the remaining DHPR-NADP^+(H) binary complexes using FlexiDock. The resulting conformations and ori-entations were compared to the original crystal complex structures for reproducibility. Then, folate, the substrate, andknown inhibitors such as methotrexate, piritrexim and trimethoprim were docked into the wild-type human DHFR and theirbinding modes were compared with X-ray crystallographic or other modeling data. The root mean square deviations(RMSDs) for ligands ranged from 1.14 to 1.57A˙, and the protein backbone RMSDs from 0.94 to 1.26A. FlexiDock repro-duced the orientations and binding modes of all seven ligands in good agreement with the crystaㅣ structures. It proved tobe a reliable and efficient program in studying binding modes of DHFR-inhibitor complexes of different species, and theinformation obtained from this work may provide additional insight into the design of new agents with improved activity.