나환자 말초혈중 (末梢血中) 혈청 및 적혈구내 Adenosine Deaminase 효소활성에 관한 연구

최유섭(Yoo Seop Choi),전인기(Inn Ki Chun),김영표(Young Pio Kim) 대한피부과학회 1983 大韓皮膚科學會誌 Vol.21 No.2

Leprosy has two polar types. The one tuberculoid leprosy (TL) is characterized by well preserved cellular immunity with a good prognosia and the other lepromatous leprosy(LL) shows no cellular immunity with a poor prognosis. The preaent study was designed to measure the activity of adenosine deaminase (ADA) in sera and erythrocytes of leprosy patients, as it's activities are known to be decreased in immune deficiency diseases. There were no significant differences in the erythrocyte ADA activities among normal subjects(9. 60+4. 43 units/1012 cells), TL patients (7. 12+2. 51 units/1012 cells) and LL patients(6. 96+0. 81 units/1012 cells), The ADA activities in sera of TL patients(20.15+2. 90 units/L) did not differ from those of normal subjects(20.44+ 2. 07 units/L), but the LL patients(17. 52+3. 30 units/L) showed a slightly lowered activity than those of normal subjects.

수종의 피부질환에 있어서 말초혈중 혈청 , 적혈구 및 임파구내 Purine Nucleoside Phosphorylase 활성에 관한 연구

최유섭(Yoo Seop Choi),이승철(Seung Churl Lee),김영표(Young Pio Kim) 대한피부과학회 1986 대한피부과학회지 Vol.24 No.4

The present study was designed to measure the activity of purine nucleoside phosphorylalse (PNPase) in sera, erythrocytes and lymphocytes of blood from patients with various dermatoses as it's activities are known to be decreased in cell-mediated immune deficiency diseases. The PNPase activities in sera, erythrocytes and lymphocytes of normal subjects were (3. 9+1. 03) X 104 unit/L, 5.04+1. 06 unit/107rbc, l. 74+0. 35 unit/103 lymphocytes respectively. In urticaria, leukocytoclastic vasculitis and purpura, there were no differences in PNPase antivities between patients groups and normal subjects. In atopic dermatitis, there were no differences in PNPase activities of sera and erythrocytes between patients group and normal subjects. But, lymphocyte PNPase activities of atopic patients were lowered than those of normal subjects(1.41 +0. 52 unit/10 lymphocytes). In tuberculoid leprosy, there were no differences in lymphocyte PNPase activities between patients group and normal subjects. But, the PNPase activities in sera and erythrocytes of patients group were lowered than those of normal subjects (3. 20. 76) X 104 unit/L, 3. 8n+1.96 unit/107rbc). The PNPase activities in sera((l. 87+0. 62) X 104 unit/L), erythrocytes(2. 08+0. 98 unit/107rbc) and lymphocytes (0.51+0. 26 unit/103 lymphocytes) of lepromatous leprosy patients were significantly lowered than those of normal subjents.

건선관절염

최유섭(Yoo Seop Choi),박경제(Kyung Jae Park),황선욱(Sun Wook Hwang),전인기(Inn Ki Chun),김영표(Young Pio Kim) 대한피부과학회 1985 대한피부과학회지 Vol.23 No.2

A psoriatic patient may have rheumatoid arthritis, psoriatic arthritis(or both), osteoarthritis or gout. In so far as possible, each of these must be distinguished on clinical grounds with some help from laboratory tests. Psoriatic arthritis is very similar to rheumatoid arthritis but clinically, it is regarded as a unique disease entity, which is found in 1% to 32% of psoriatic individuals. We herein report two cases of psoriatic arthritis that are thought to be distal type and arthritis mutilans on the basis of clinical, serological and radiological features.

누적로짓모형을 이용한 주거지 침수 위험에 대한 지불의사 분석

최열(Choi Yeol),최유섭(Choi Yoo Seop),김용태(Kim Yong Tae) 대한토목학회 2007 대한토목학회논문집 D Vol.27 No.5D

본 연구에서는 조건부가치측정법을 이용하여 주민들이 침수해 대해서 느끼는 위험 혹은 불안감의 정도를 파악하고자 하였다. 분석을 위해서 응답자가 지불의사금액을 결정하는데 영향을 줄 것이라고 예상되는 변수들을 과거 침수피해와 관련된 변수집단, 방재대책에 대한 인식, 그리고 응답자의 개별속성이라는 세 가지 범주로 나누어 독립변수로 사용하였다, 응답자의 지불의사금액에 영향을 미치는 요인들이 실제로 지불의사금액 결정에 어느 정도의 영향을 미치는지에 대한 정보를 얻기 위해서 누적로짓분석을 실시하였다. 분석 결과를 요약하면 다음과 같다. 응답자의 홍수보험료 지불의사금액에 유의한 영향을 주는 변수는 응답자가 생각하는 침수발생 가능성, 방재대책의 필요성, 홍수보험의 필요성, 그리고 응답자의 연령과 주택규모였다. 침수발생 가능성에 관련된 변수를 살펴보면 응답자가 느끼는 침수발생 가능성이 한 수준 더 높아지면 더 높은 금액을 지불할 기능성이 더 낮은 금액을 지불할 가능성보다 다소 높아지는 것으로 나타났다. 방재대책의 필요성과 홍수보험의 필요성을 나타내는 변수는 응답자들이 느끼는 필요성의 수준이 한 수준 높아지면 더 높은 금액을 보험료로 지불할 가능성이 각각 1.752배과 1.474배 높아졌다. 또한 응답자의 연령이 낮아질수록 더 높은 금액을 지불할 가능성이 다소 높아지고, 주택의 규모가 커질수록 더 많은 금액을 지불할 가능성이 1.018배 높아진다는 것을 보여주었다. The aim of this paper is to explore and estimate the residents fear and anxiousness against flood using contigent value method. For this, we at large classified independent variables to determine residents's willingness to pay against flood into three categories, previous experiences, measures against flood, and respondent's individual characteristics. We employed the accumulative logit model to examine and estimate the odds of variables to impact residents willingness to pay for flood risk. The concluding remarks from the empirical analyses through such model are as follows; It is found that the variables to denote the flood possibilities, necessities against flood measurements and flood insurance, respondents age and housing size are statistically significant predictors to willingness to pay. Particularly, the residents who have revealed high possibilities for flood and have considered the necessities of flood measurements and flood insurance are likely to associate with high willing to pay against flood. These findings provide policy makers related with flood with more valuable information.

나환자 말초혈중 임파구내 Adenosine Deaminase 효소 활성에 관한 연구

김영표(Young Pio Kim),최유섭(Yoo Seop Choi) 대한피부과학회 1983 大韓皮膚科學會誌 Vol.21 No.4

Leprosy is an infectious diseases caused by Mycobacterium leprae. It is considered to be manifested in person with an impaired. immune system and is divided into two polar forms; the first being tuberculoid leprosy(TL) with nearly norrnal cell-mediated immunity(CMI) and the second heing lepromatous leprosy(LL) with deficient CMI. Adenosine deaminase(ADA) is an enzyme concerned with intermediary purine metabolism, which is known to be deficient in case of immunological dysfunction. To find out if there is any ADA deficiency in leprosy, the ADA activities in the lymphocytes of leprosy patients were compared with those of normal ones. The ADA activities in lymphocytes of normal subjects, TL patients and. LL patients were as follows; ID. 36-I-l. 90 units/10cells, 6. 35+0. 86units/10'cells and 4. 58+0. 52units/IO'cells respectively. The ADA activities in lymphocytes were revealed to be significantly different between normal subjects and LL patients(p <0. 01) and also between normal subjects and TL patients(p<0. 05). The lowered ADA activities in lymphocytes of leprosy patients, particularly in lepromatous leprosy, suggests a similar role in ADA for immunological response as demonstrated in severe combined immunodeficiency diseases.

정상인 피부조직내의 Adenosine Deaminase에 관한 연구 ( 제 II 보 )

임철완(Chull Wan Ihm),김영표(Young Pio Kim),최유섭(Yoo Seop Choi) 대한피부과학회 1983 대한피부과학회지 Vol.21 No.1

Adenosine deaminase (adenosine aminohydrolase, E.C.3. 5. 4. 4; ADA), which catalyzes the deamination of adenosine to yield inosine and ammonia, was characterized in the human penile foreskin. ADA was found to be present in both layers of the skin with slightly higher activity in the epidermis(Epidermis; (7. 2+2. 3) * 10-4 unit/mg protein, Dermis;(5. 7 +1. 9) *10-4 unit/mg protein). The enzyme exhibited a broad pH optimum from 6. 5 to 8. 0 in both layers of the skin, and was heat-labile, being completely inactivated by heat treatment at 70C-75 C for 10 minutes. In contrast to the ADA of other tissue, the enzyme was inhibited by 2 mM of Cu2+, Fe2+ and Co2+ at pH7. 0 in both layers of the skin. The inhibitory effect of Cu2+ on the enzyme was stronger than other metal ions, and the enzyme was completely inactivated by 20 mM of Cu2+ in both layers. The Cu2+ inhibited enzyme activities which were recovered by adding EDTA. From the above results, it is suggested that the enzyme in both layers of the skin are consisted of same types of isozymes.

癩患者 末梢血中 血淸 및 赤血球內 purine nucleoside phosphorylase 活性에 關한 硏究

金永杓,田寅淇,崔有燮 大韓癩學會 1984 癩學 會誌 Vol.17 No.1

Purine Nucleoside Phorphorylase Activities in Lymphocytes of leprosy patients

Kim,Young-Pio,Choi,Yoo-Seop,Park,Kyung-Jae,Chun,Im-ki 大韓癩學會 1985 癩學 會誌 Vol.18 No.1

국소스테로이드제의 부작용에 관한 연구

전인기,김영표,최유섭 대한피부과학회 1982 대한피부과학회지 Vol.20 No.6

Since Epsteins report in 1963, which identified topical corticosteroid therapy as a possible cause of striae formation, many adverse effects resulting from topical steroids therapy has heen observed in dermatological practice. In this study, 365 cases of side-effects with topical steroids in Department of Dermatology, Chonnarn University Hospital from 1972 to 1981 were analyzed, and the results obtained can be summerized as follows; 1. During this period, themean average percent of side effects with topical steroids was 0.85 of the yearly total patients and 12 different kinds of side-effects were found to be present in this study. 2. The annual rate of increase of side-effects with topical steroids (2.4%) was higher than that of yearly total patients (0.5%) and the annual frequency of the 12 side-effects was shown in Table 1. 3. The frequency of the 12 side-effects by age group was shown in Table 2. 4. The frequency of the 12 side-effects by season, sex and region was shown in Table 3. 5. The frequency of the 12 side-effects by lesion site was shown in Table 5. 6. T.he mean period of application with topical steroids was 4. 18 months and applied topical steroids were betamethasone-17-valerate(30.4%), fluocortolone (22.7%), hetamethasone dipropionate(12.9%), fluocmolone acetonide (9.0%) and prednisolone(8.8%) respectively. 7. The most frequent topical steroids and period of application causing each side-effects were as follows: betamethaaone-17-valerate for 1 month resulting in Steroid acne, betamethasone-17-valerate for 2 months resulting in Telangiectasia rubeosis et steroidica, triamcinolone acetonide for 1 month resulting in Perioral dermatitis and betarnethasone-17-valerate for 11 months resulting in Atropic striae.

위암을 동반한 피부근염의 1 예

김종민,전인기,김영표,최유섭 대한피부과학회 1982 大韓皮膚科學會誌 Vol.20 No.2

We wish to report herein a case of dermatomyositis associated with gastric adenocarcinoma in 70-year-old woman, and reviewed the literature on the reltaionship of dermatomyositis and malignancy.