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고콜레스테롤혈증 토끼에서 녹차추출물의 동맥경화 치료효과
채희열(Hee-Youl Chai),권운(Woon Kwon),김태명(Tae Myoung Kim),김한얼(Haneul Kim),이남진(Nam Jin Lee),신지순(Ji-Soon Sin),이덕근(Deok Keun Lee),박종범(Jong Bum Park),박승경(Sung-Kyeong Park),황석연(Seock-Yeon Hwang),김윤배(Yun-Bae Kim 한국실험동물학회 2004 Laboratory Animal Research Vol.20 No.3
Cholesterol-lowering and antiatherosclerotic effects of green tea extract were evaluated in hypercholesterolemic rabbits produced by feeding on high-cholesterol diet. Male New Zealand White rabbits were fed on only hypercholesterol diet containing 1% cholesterol and 2% corn oil for 2 weeks, and then green tea extract (1%) or lovastatin (0.002 %) were added to the diet for additional 8 weeks. Blood cholesterol level was greatly increased by 2-week feeding on the hypercholesterol diet to 25 fold (mean 1,057.8 ㎎/㎗) of control level (42.5 ㎎/㎗), and maintained high for additional 8 weeks, in spite of slight reduction to 92.2 % of initial hypercholesterolemia. Such a hypercholesterolemia was significantly reduced by 8-week feeding on green tea extract and lovastatin to 62.6% and 67.4% of initial levels, respectively. Low-density lipoproteins were also markedly enhanced by hypercholesterol diet for 2 weeks to 34 fold (mean 533.3 ㎎/㎗) of control (15.8 ㎎/㎗), and increased further by 181.9 ㎎/㎗ during 8-week feeding on the diet. Compared to no effect of green tea extract (181.3 ㎎/㎗), lovastatin (63.0 ㎎/㎗) significantly attenuated the increase in the level of low-density lipoproteins during 8 weeks. On the other hand, triglycerides were not affected by hypercholesterol diet, and the level of high-density lipoproteins, which had been increased (3.6 fold of control) by hypercholesterol diet, were not considerably affected by green tea extract or lovastatin. Interestingly, thick atheromatous plaques on the wall of aorta of rabbits fed on hypercholesterol diet were markedly attenuated by green tea extract or lovastatin, leading to the decreases in athrosclerosis indices to 1.75 and 1.25, respectively, from 2.25 of rabbits fed on hypercholestrol diet alone. In addition, green tea extract lowered lipid deposition in hepatocytes, showing restricted distribution of foamy hepatocytes. Taken together, it is suggested that green tea extract exert antiatherosclerotic effect by reducing blood cholesterol level.
콜레스테롤 함유 식이 랫드에서 감귤껍질추출물 BNs-3 및 BNs-7의 항비만 효과
채희열(Hee-Youl Chai),신지순(Ji-Soon Sin),권운(Woon Kwon),최은경(Ehn-Kyoung Choi),조영민(Young Min Cho),장호송(Hu-Song Zhang),황석연(Seock-Yeon Hwang),복성해(Song-Hae Bok),김윤배(Yun-Bae Kim),강종구(Jong-Koo Kang) 한국독성학회 2003 Toxicological Research Vol.19 No.3
The protective effects of BNs-3 and BNs-7, extracts of citrous orange peel, on the obesity induced by ad libitum feeding a cholesterol-containing diet to rats were investigated. The animals<br/> were fed on the diet including cholesterol (0.5%) with or without the citrous orange peel extracts BNs-3 (5%) and/or BNs-7 (0.1%) for 8 weeks. The ad libitum feeding a diet containing cholesterol to<br/> rats from 6 weeks of age increased the body weight gain compared with that of rats fed on a normal diet. Such an increase in body weights was markedly attenuated by the addition of BNs-3 or BNs-7 to the diet. Especially, a combinational feeding on BNs-3 and BNs-7 significantly reduced the body weight gain below that of normal diet-fed animals. Interestingly, the weights of abdominal adipose tissues surrounding epididymides were greatly reduced by the citrous orange peel extracts, in parallel with the decrease in body weights. In addition, blood concentrations of lipids including cholesterol were also lowered by the combinational treatment with BNs-3 and BNs-7. Taken together, it is suggested that the obesity and overweight produced by unrestricted overfeeding on diet with cholesterol may be partially due to the accumulation of abdominal adipose tissues, around the epididymides in rats, and that citrous orange peel extracts might exert antiobese activities by reducing the adipose tissues as well as blood lipid concentrations.
토끼에서 고콜레스테롤 유도 동맥경화에 대한 활기단 SJ-101의 개선효과
조정희(Jung-Hee Cho),이남진(Nam Jin Lee),채희열(Hee-Youl Chai),김태명(Tae Myung Kim),박정휘(Jung-Hui Park),강종구(Jong-Koo Kang),김윤배(Yun-Bae Kim),황석연(Seock-Yeon Hwang) 한국실험동물학회 2005 Laboratory Animal Research Vol.21 No.2
The purpose of this study was to confirm the improving effect of the Hwalgidan SJ-101 on hypercholesterolemia and ensuing atherosclerosis in rabbits. Male New Zealand White rabbits were fed on only hypercholesterol diet containing 1% cholesterol and 2% corn oil for 2 weeks, and then Hwalgidan SJ-101 (1% or 3%) or lovastatin (0.002%) were added to the diet for additional 8 weeks. Blood cholesterol levels, especially low-density lipoproteins (LDL), were greatly increased by 2-week feeding on the hypercholesterol diet to 25 - 35 fold of control, and further increased during additional 8 weeks, in contrast to reduction of high-density lipoproteins (HDL). Such a hypercholesterolemia was significantly reduced by 8-week feeding on Hwalgidan SJ-101 or lovastatin. In addition, the hypercholestrol diet-induced decrease in HDL and increase in triglycerides were reversed by Hwalgidan SJ-101 or lovastatin. Moreover, thick atheromatous plaques on the wall of aorta of rabbits fed on hypercholesterol diet were markedly attenuated by Hwalgidan SJ-101 or lovastatin, leading to the decreases in atherosclerosis indices to 2.0, respectively, from 2.75 of rabbits fed on hypercholesterol diet alone. In addition, Hwalgidan SJ-101 lowered lipid deposition in hepatocytes, showing restricted distribution of foamy hepatocytes. Interestingly, however, lovastatin caused hepatic centrilobular congestion, leading to great increase in serum alanine transaminase and aspartate transaminase activities, in contrast to normal levels in Hwalgidan SJ-101-treated animals. In conclusion, the results suggest that Hwalgidan SJ-101 improves hyperlipidemia and ensuing atherosclerosis, without hepatotoxicity, probably by both controlling lipid metabolism and reducing free radical reactions.
고지혈증 토끼에서 상백피 에탄올추출물의 동맥경화 개선효과
홍성희(Seong-Hee Hong),채희열(Hee-Youl Chai),김태명(Tae Myoung Kim),이남진(Nam-Jin Lee),김동규(Dong-Kyu Kim),조정희(Jung-Hee Cho),박정휘(Jung-Hui Park),김윤배(Yun-Bae Kim),강종구(Jong-Koo Kang),황석연(Seock-Yeon Hwang) 한국실험동물학회 2005 Laboratory Animal Research Vol.21 No.3
Hyperlipidemia is one of the risk factors for atherosclerosis. This study was conducted to investigate the cholesterol-lowering and antiatherosclerotic effect of Mori radicis cortex-ethanol extracts (MRC-EE) in hypercholesterolemia produced by feeding on high-cholesterol diet in rabbits. Male New Zealand White rabbits were fed on only high-fat fed diet containing 1% cholesterol and 2% corn oil for 2 weeks, and then MRC-EE (1% or 3%) or lovastatin (0.002%) were added to the diet for additional 8 weeks. The levels of blood cholesterol, low-density lipoproteins (LDL) and high-density lipoproteins (HDL) were greatly increased by 2-week feeding on the high-fat diet, compared with those of animals fed on normal diet. Blood concentrations of cholesterol, LDL and triglycerides further increased during additional 8-week feeding on high-cholesterol diet alone, in contrast to significant decrease in HDL level. In comparison, the levels of cholesterol and LDL were reduced by lavastatin and MRC-EE, in addition to less-severe decrease in HDL contents. The levels of alanine transaminase (ALT) and aspartate transaminase (AST) significantly increased in lovastatin-treated rabbits, but not in MRC-EE-fed animals. In addition, MRC-EE (3%) lowered lipid deposition in hepatocytes, showing restricted distribution of foamy hepatocytes, in constrast to hepatic centrilobular congestion and hepatotoxicity caused by lovastatin. The thick atheromatous plaques (mean score 2.75) on the aortic wall of rabbits fed on high-fat diet were markedly attenuated by MRC-EE (3%) or lovastatin, leading to the decreases in athrosclerosis indices to 2.0. These results suggest that MRC-EE (3%) exerts antiatherosclerotic effect by reducing atherosclerosis index without hepatotoxicity.
암컷 랫드의 생식기능에 미치는 반하 (Pinellia ternata) 추출물의 영향
김윤배(Yun-Bae Kim),채희열(Hee-Youl Chai),이기창(Ki-Chang Lee),윤영원(Young Won Yun),김대중(Dae Joong Kim),남상윤(Sang-Yoon Nam),노재섭(Jai Seup Ro),황방연(Bang Yeon Hwang),강현구(Hyun-Gu Kang) 한국실험동물학회 2005 Laboratory Animal Research Vol.21 No.1
Effects of water extract of Pinellia ternata on vaginal opening, estrous cycle, blood estrogen concentrations and uterine glutathione peroxidase activity were investigated in immature and mature female rats. In pubertal onset assay, immature rats were orally administered with Pinellia ternata extract at doses of 20, 200 or 2,000 ㎎/㎏ for 20 days from day 21 of age, and sacrificed after the final administration for the morphological and enzymatic analyses in reproductive organs. During the administration period, estrous cycle was determined by vaginal cytology from the vaginal opening day. Separately, estrous cycle and daily blood concentrations of estrogen were measured from 11th day during 20-day treatment with Pinellia ternata extract in mature rats of 10 weeks old. In pubertal onset assay, vaginal opening time was somewhat delayed by the administration with Pinellia ternata at all doses used, in contrast to a marked advance in rats treated with 17β-estradiol (10 ㎍/㎏). However, Pinellia ternata increased uterine glutathione peroxidase activity which was also observed in animals treated with 17β-estradiol. Interestingly, Pinellia ternata prolonged the diestrus period in both immature and mature rats. On the contrary, 17β-estradiol arrested the estrous cycle at estrus stage in immature rats, although it prolonged diestrus-proestrus periods in mature animals. Taken together, it is suggested that the water extract of Pinellia ternata might influence the female reproductive function somewhat differently from 17β-estradiol, and that the toxicity and action mechanism of Pinellia ternata following long-term exposure remain to be clarified.