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황금의 Flavonoid 성분들이 Rat 수정체의 백내장 형성과 Polyol 축적에 미치는 효과
신국현(Kuk Hyun shin),채윤정(Yun Jung Chae),정명숙(Myung Sook Chung),이희주(Hee Ju Lee) 한국생약학회 1994 생약학회지 Vol.25 No.1
The ether, ethylacetate and n-butanol soluble fractions from the roots of Scutellaria baicalensis showed a significant inhibition of lens aldose reductase (AR) activity in vitro. During systematic fractionation of the active fractions, 7 flavonoids were isolated and compared their inhibitory activities against rat AR using DL-glyceraldehyde as a substrate, among which baicalin (VII) was found to exhibit the most potent inhibitory activity. Baicalin (VII) and wogonin-7-O-glucuronide (VI), with repeated treatments (30 ㎎/㎏/day, i.p.) throughout the experimental periods caused a significant suppression of cataract formation induced by galactose (40 g/㎏/day) as well as the decrease of galactitol accumulation in the rat lens. The flavonoids also exhibited a significant inibition of sorbitol accumulation in the lenses of diabetic rats induced by streptozotocin (STZ).
효모에서 발현된 유전자 재조합 탈메치오닌 인간 성장호르몬의 일반 약리작용
이은방(Eun Bang Lee),신국현(Kuk Hyun Shin),김운자(Oon Ja Kim),윤기영(Ki Young Yoon),천선아(Seon Ah Cheon),채윤정(Yun Jung Chae) 대한약학회 1992 약학회지 Vol.36 No.1
The general and some other pharmacological actions of growth hormone without N-terminal methionine(rhGH) were investigated in animals. The hormone had no influenced on the central nervous system and on body temperature at a high oral dose of 40IU/kg in animals. It had neither analgesic nor antiepileptic actions at the High doses. In the isolated ileum and trachea of guinea-pig and isolated stomach fundus and uterus of rat, it showed neither contractive nor relaxing effets at a concentration of 1 X 10-3IU/ml in bath, and no inhibitory action at a dose of 1 X 10-3IU/ml against the contractions produced by histamine (5 X 10-5g/ml), serotonin(1 X 10-5g/ml, acetylcholine(1 X 10-5g/ml) and oxytocin(5 X 10-3IU/ml). Furthermore, the intravenous infection of 20IU/kg rhGH had no influences on the normal blood pressure and respiration in rabbits. These negative results in pharmacological profile are thought that the hormone may not elicit serious side effects On the other hand, the rhGH exhibited a weak inhibitory action of glucose tolerance in normal rats, significantly lowered the blood glucose contents in adrenalectomiglucose tolerance in normal rats, significantly lowered the blood glucose contents in adrenalectomized rats 20 min after i.v. administration of 80IU/kg, and showed a significant inhibitory effect on in vitro glycerol release in epinephrine-stimulated epididymal fat pad segments of rats.