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Comparative binding of antitumor drugs to DNA containing the telomere repeat sequence
서동철,오유경,안병찬,허만욱,김혜자,이미형,주효순,어청균 생화학분자생물학회 2002 Experimental and molecular medicine Vol.34 No.5
Rat hippocampal precursor cells isolated from hippocampi of embryonic day 16.5 (E16.5) rat em-bryos were found to proliferate in the presence of basic fibroblast growth factor. Addition of soluble neural cel adhesion molecule (NCAM) to these precursor cels reduced cel proliferation in a dose dependent manner and enhanced the induction of precursor cels' diferentiation to the neuronal line-age. Given these findings that NCAM induces the diferentiation of hippocampal precursor cels, we investigated posible efects of NCAM on the ex-pression of basic helix-loop-helix (bHLH) tran-scription factors during the diferentiation. Sol-uble NCAM upregulated the transcription of bHLH decreased HES5. Western blot analysis showed that NCAM increased the expresion levels of CaMKII, p-MAPK, GluR1 and NR1 but decreased p-STAT3. These results suport a role for NCAM in the inhibition of proliferation and the induction of neural diferentiation of hippocampal neural pre-cursor cels, and act as developmental regulators of the bHLH families, ultimately leading to the generation of glutamatergic neural cel types in the diferentiation of hippocampal precursor cels.