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양극성 장애 조증과 혼재성 삽화의 치료제로서 Topiramate 단독요법의 항조증 효과와 안정성에 대한 예비 연구
천봉희,권성민,장진열,조성남,조 웅,권도훈 대한생물치료정신의학회 2002 생물치료정신의학 Vol.8 No.2
저자들은 양국성 장애 조중삽화 및 혼재성 삽화의 단독 치료제로서 새로운 항경련제인 topiramate의 항조증 효과와 안정성을 평가하기 위하여 본 연구를 하였다. 양극성 장애 조증 삽화와 혼재성 삽화로 진단이되어 입원을 한 환자 14명(남자 6명, 여자 8명)을 대상으로 topiramate를 단독으로 6주간 투여하였다. Young's Manic Rating Scale(YMRS), Brief Psychotic Rating Scale(BPRS)로 환자들의 증상정도를 평가하였으며, 추가해서 체중변화도 측정하였다. 연구결과, YMRS, BPRS 평균점수 및 체중은 topiramate 치료 전에 비해 6주 치료 후에 유의하게 감소되었다. 또, YMRS 점수가 20미만일 때 조증상태가 안정된 것으로 본다면, 본 연구에서 치료 6주 후 YMRS 점수가 20미만인 환자는 14명 중 7명으로 topiramate의 치료 반응률은 50%라 할 수 있다. 가장 흔한 부작용은 위장관 증상으로서 식욕감퇴, 구역, 설사 등이었으며, 이는 6주 연구 후에 topiramate 치료를 중단하게 하는 원인이었다. 진전이나 이상감각은 대체로 topiramate를 투여한 후 1∼2주 내에 나타났다가 1∼2주 지속된 후 사라졌다. 향후 연구에서는 본 연구의 제한점을 보완하는 대조군 연구가 필요하며, 부작용을 줄이기 위한 보다 적절한 topiramate의 증량방법도 고안되어야만 할 것이다. Objectives : Topiramate is a newly developed anticonvulsant agent with possible mood-stabilizing properties. The purpose of this study is to explore the antimanic efficacy and the tolerability of topiramate as monotherapy in bipolarⅠdisorder, most recent episode manic or mixed. Method : In this study, fourteen hospitalozed patients who met the DSM-Ⅳ criteria for bipolarⅠdisorder, most recent episode manic or mixed were given topiramate monotherapy for up to 6 weeks. The response to topiramate was assessed with Young's Manic Rating Scale(YMRS) and Brief Psychotic Rating Scale(BPRS). Body weight changes were also measured. The Ratings were completed at baseline nad then on 1,2,3,4, and 6 weeks. Results : The mean Young's Manic Rating Scale(YMRS) score improved from 38.36(25-42) at baseline to 22.29(12-37) at the end of the study. The Brief Psychotic Rating Scale(BPRS) score improved from baseline mean of 44.64(35-60) to a last observation of 28.92(13-43). The mean body weight decreased from 62.43kg(47-81kg) to 58.64kg(45-81kg). At the end of study, seven patients scored less than 20 on the YMRS score, three of them were less than 13, Adverse events included anorexia(N=9), nausea(N=6), diarrhea(N=4), paresthesia(N=4), tremor(N=2), and rash(N=1). Conclusion : In this study, the response rate to topiramate was 50% as a treatment agent for bipolarⅠdisorder, most recent episode manic or mixed and topiramate might be associated with weight loss. But the adverse effects such as gastrointestinal sympotoms decreased the compliance of topiramate. Inthe future, double-blind controlled studies are needed to further investigate the antimanic efficacy and tolerability of topiramate.
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Comparison of Lumbar Spine Load in Mild Scoliosis Subjects Performing Wall-Facing Squats
조 웅,한재웅 국제물리치료연구학회 2023 Journal of International Academy of Physical Ther Vol.14 No.2
Background: It is well known that squat exercises are good for scoliosis patients. Especially wall facing squat (WS) is believed to be more effective than normal squat (NS). Objectives: In order to find out what effect the wall squat has on the rehabilitation exercise of patients with lumbar scoliosis compared to the conventional squat, the force between the lumbar segments was compared using a motion analysis system. Design: Quasi-experimental study. Methods: In this work, an attempt was made to provide a scientific basis for these experiences. Inverse dynamics simulations were performed for each of the 10 subjects with mild scoliosis during NS and WS using subject-specific 3D musculoskeletal models. Exercises with three sets of five cycle for NS or WS were performed. Muscle forces calculated from the simulations were compared with electromyography data for verification. Results: The imbalance of muscle forces between the right and left in erector spinae (ES) decreased with the progress of WS sets. The difference of 14.1% for the 1st set diminished to 1.8% during the 3rd set. Conclusion: The overall level of right and left ES muscle forces also increased from the 1st set to the 3rd set. The results of simulations indicated that WS was more effective than NS for scoliosis correction.
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박광석,노현웅,박정호,박승조 동아대학교 환경문제연구소 1997 硏究報告 Vol.20 No.1
The effects of formaldehyde in anaerobic digestion were : 1. In the cases of batch assay, the methanogenic bacteria were tolerated the toxic when raw and pretreated wastewaters were injected 3 and 5 ml respectively to serum bottle, but shocked when 5 and 10 ml respectively. 2. When raw, pretreated + glucose, and pretreated wastewaters were applied to UASB reators, the results of VLR were obtained 8-10, 3-5, and 2-4 kg cod/㎥ ·d respectived. Result of raw wastewater was the most optima of three. 3. The correlations VLR with bio-gas were obtained 90.5, 46.4 and 34.6% respectively in raw, pretreated + glucose, and pretreated wastewaters. Result of raw wastewater was the most optima of three. 4. In batch assay, pretreatment wastewater is better than raw water, but in continuous assay, raw wastewater is better than pretreatment wastewater. This reason is consideated that unsoluble salt of 373 mg/l is accumulated within UASB reactor, and carries out inhibition to anaerobic bacteria.
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김영웅,노현웅,박승조 동아대학교 환경문제연구소 1997 硏究報告 Vol.20 No.1
The objective of this study was to conduct jar-tests to remove residual aluminum ion and turbidity using three coagulants and three alginates as a coaglant aids. The conclusions were obtained from investigation of coagulant demand, zeta potential, residual aluminum ion concentration and turbidity under varying dosage of coagulants are as follows ; The potimum dosages for ALUM, PAC and PASS were 50, 35 and 30 mg/l respectively, at these dosages, residual aluminum ion concentrations were 0.07, 0.10 and 0.13 mg/l. When magnesium alginate(MA) dosage of 1.0 mg/l was applied after addition of optimum dosages of coagulants, ALUM, PAC and PASS removal efficiency of turbidities were 0.10, 0.13 and 0.13 NTU respectively. Adequate zeta-potential range for coagulation was from -20 mV to -10 mV with coagulant only.
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