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김병진 ( Byung Jin Kim ),함경완 ( Kyung Wan Ham ),박경배 ( Kyung Bae Park ),김대현 ( Dae Hyeon Kim ),조범연 ( Beom Yeon Jo ),조창래 ( Chang Re Cho ),조길환 ( Gil Hwan Cho ),배기상 ( Gi Sang Bae ),박경철 ( Kyoung Chel Park ),구본순 대한본초학회 2009 大韓本草學會誌 Vol.24 No.3
Objectives: The purpose of this study was to investigate the anti-inflammatory effects of extract from Trogopterorum Faeces (TF) on the RAW 264.7 cells. Methods: To prove the TF`s anti-inflammatory effects, we investigated nitric oxide (NO) production and own cell viability. We examined the cytokine productions on lipopolysacchride (LPS)-induced RAW 264.7 cells and also cellular regulatory mechanisms. Results: TF does not have any cytotoxic effect. TF reduced LPS-induced NO production, interleukin (IL)-1b, IL-6, IL-10 and tumor necrosis factor-a (TNF-a) in RAW 264.7 cells. TF inhibited the activation of mitogen-activated protein kinases (MAPKs) such as p38, extracelluar signal-regulated kinase (ERK 1/2) and c-Jun NH2-terminal kinase (JNK) and also the degradation of inhibitory kappa B a (Ik-Ba) in the LPS-stimulated RAW 264.7 cells. TF reduced the serum levels of IL-1b, IL-6, TNF-a. The survival rate of LPS-induced endotoxin shock was increased by TF administration. Conclusions: TF down-regulated LPS-induced NO and cytokines production, which could provide a clinical basis for anti-inflammatory properties.