매독의 혈청학적 검사 - VDRL , FTA - ABS 및 TPHA 검사 결과의 비교 -

조정구(Chung Koo Cho),이정복(Jung Bock Lee),이성낙(Sung Nack Lee),한신원(Shin Won Han) 대한피부과학회 1984 大韓皮膚科學會誌 Vol.22 No.4

On a total 375 sera with reactive results on VDRL and/or FTA-ABS test(s), derived from severance Hospital, qualitative and quantitative TPHA tests were carried out. The objectives of the present study were to compare the result of VDRL, FTA-ABS and TPHA teats in different syphilis stages, and to as sess the suitability of the TPHA test as a screening test for syphilis. The results are summarized as follows: 1. The sensitivity of VDRL test was poor compared with TPHA and FTA-ABS tests except in secondary syphilis. 2. The FTA-ABS test(10Qp,) was more sensitive than the TPHA test(86g) in primary syphilis, but it is time consuming and costly. 3 The TPHA titers were relatively low in primary syphilis. 4, Below 1: 32Q in TPHA titer, the percentage of sera from patients tested over 1 year(64%) after the completion of treatment was higher than within 1 year(41%). The TPHA test showed 77%. agreement with VDRL test and 89% agreement with FTA-ABS test. The VDRL test is easy to perform and economic, but it showed poor effeetiveness as screening test for the detection of syphilis. On the other hand the TPHA test had a wide spectrum of reactivity in different stages of syphilis and was easy to perform. So on the basis of the results presented, we concluded that the TPHA test provides a very effective screen for syphilis.

장시간 고온노출이 땀분비에 미치는 영향에 관한 연구

조정구(Chung Koo Cho),강원형(Won hyoung Kang),이성낙(Sung Nack Lee) 대한피부과학회 1984 대한피부과학회지 Vol.22 No.2

Impaired sweating reportedly has been associated with a high incidence of heat pyrexia. An important cause is attributed to sweat gland fatigue following intense prolonged sweating. For further investigation, sweat gland fatigue was induced by heat exposure for 2 hours in a hot room (dry bulb 46c, wet bulb 37c) with 9 healthy subjects. Sweating rate of the right forearm increased progressively for the first 45 minutes with a maximum value of 40.0mg/4. 91 cm2/15 min followed by a slow decrease to 24.9 mg/4.91cm2/15 min at the end of 2 hours. Active sweat pores decreased in number following 2 hours of heat exposure but the differences were not significant statistically. In spite of the higher sweat rate on the back, the number of active sweat pores was smaller as compared to the right forearm. Na+ concentrations of the second hour sweat collections were higher than those of the first hour with difference of 14. 9 mEq/l on the right forearm and 12.3 mEq/1 on the back.

한국남자 대학생들의 여름철 피부색 변화에 관한 연구

이해을(Hae Eul Lee),조정구(Chung Koo Cho),이성낙(Sung Nack Lee) 대한피부과학회 1984 대한피부과학회지 Vol.22 No.2

This study was undertaken to clarify whether the color changes of skin in summer are remarkable or not. The skin color of abdomen, extensor and flexor of forearm, forehead, and cheek were measured in 27 health male students who had never tanned their skin intentionally during this experiment with Color and Color Difference Meter(Nippon Denshoku Kogyo Ca. CP6R 1001-DP) which represents skin color as 'L', 'a', and 'b' values. The 'L', 'a', and 'b' values mean the degree of lightness, redness, and yellowness respectively. Measurements had been performed four times repeatedly from summer(june) to auturmn(October) with intervals of 6 weeks. The obtained values were evaluated with statistical method, and the results were sumrnarized as follows: l. Abdominal skin showed no significant color changes in this experiment. 2 Extensor and flexor skin of forearm showed significant decrease in lightness from July, and the degree of decrease was more remarkable on extensor skin than on flexor skin. The lighteness had not been recovered by October on extensor skin and by September on flexor skin. There was no significant change in redness and yellowness on both places in this experiment. 3. Forehead skin showed no significant change in lightness and yellowness in this experiment, and showed transient decrease in redness in July. 4. Cheek skin showed no significant change in lighteness and redness in this experiment, and showed transient increase in yellowness in October.

최근 5년간 피부질환의 통계적 고찰

방동식(Dong Sik Bang),조정구(Chung Koo Cho),이성락(Sung Nack Lee) 대한피부과학회 1983 大韓皮膚科學會誌 Vol.21 No.1

The incidence of skin diseases in the hospital practice cannot give a true picture of their prevalence in the population served. Nevertheless the hospital incidence figures usually offer the only available means of assessing prevalence, and therefore provide us with a potentially valuable source of information on the ecology of many skin disorders. (countinued..)

건선에 대한 경구용 Etretinate ( Ro 10 - 9359 ) 및 Vitamin E의 병용치료 효과

이성낙 ( Sung Nack Lee ),이정복 ( Jung Bock Lee ),조정구 ( Chung Koo Cho ),이해을 ( Hae Eul Lee ),김수찬 ( Soo Chan Kim ),김덕현 ( Duck Hyun Kim ),방동식 ( Dong Sik Bang ),이승헌 ( Seung Hun Lee ),박한성 ( Han Sung Park ),국홍일 ( 대한피부과학회 1984 大韓皮膚科學會誌 Vol.22 No.2

Etretinate(Ro 10-9359), an aromatic analogue of vitamin A acid, has been known to be effective in the treatment of psoriasis, Darier's disease, pityriasis rubra pilaris, ichthyosis, and palmoplantar keratoderma when administered orally. In this experiment, we compared the therapeutic and side effects between a group with high dose therapy(initially 75mg of etretinate a day) and an another group with low dose therapy(initially 40mg of etretinate a day). We also observed whether the pretreatment followed by combined treatment with vitamin E could potentiate the therapeutic effect as well as reduce the side effects of oral etretinate. This experiment comprised 102 moderate to severe psoriatic patients. The following results were obtained from this experiment. 1. Fifty-six among 92 patients(61%) who were treated with etretinate for more than 4 weeks showed good to excellent therapeutic effect. 2 The high dose therapy was more effective, but showed more side effects than low dose therapy. 3 Vitamin E did not potentiate the effect of etretinate. In low dose therapy, the pretreatment followed by combined treatment with vitamin E showed a tendency to reduce the side effects of etretinate.

스테로이드성 좌창에 대한 13 - cis - Retinoic Acid의 치료효과

황경희(Kyung Hee Whang),고창조(Chang Jo Koh),이성낙(Sung Nack Lee),조정구(Chung Koo Cho) 대한피부과학회 1983 대한피부과학회지 Vol.21 No.1

13-cis-Retinoic Acid(isotretinoin, Ro 4∼3780)는 vitamin A acid의 합성유도체로서 최근 좌창에 이를 투여하여 좋은 효과가 있음이 보고되고 있다. 근래에는 부신피질 호르몬 제제의 남용으로 인한 스테로이드성 좌창이 문제가 되고 있어 저자들은 13-cis-Retinoic Acid를 스테로이드성 좌창의 치료에 도입하였다. 실험대상은 부신피질 호르몬제제를 1개월이상 장기간 국소도포 혹은 경구투여함으로서 발생한 스테로이드성 좌창환자 19명을 대상으로 하였다. 13-cis-Retinoic Acid는 처음 2내지 4주간은 매일 체중당 0.7㎎으로 경구투여 하였고, 그 후 증세호전에 따라 0.3내지 0.5㎎으로 감량하여 투여한 바 8주후에는 19명중 13명에서 완전 치유되었으며 8명에서도 현저한 호전을 보였다. 부작용은 구순염이 전예에서 보였고 이외에 각막염, 소양증이 각6명, 두통이 1명이었으나 그정도는 아주 경하여 투여를 중단할 필요가 없었고 투여량의 감소로 점차부작용이 소실되었다. 치료전 과후에 혈액검사, 요검사 및 간기능 검사를 시행하였으나 모두 정상이었다. N/A

선천성 매독 : 매독에 감염된 산모에서 태어난 태아의 운명과 조기 선천성 매독의 임상증세

이정복(Jung Bock Lee),이동건(Dong Kun Kim),조정구(Chung Koo Cho),이성낙(Sung Nack Lee) 대한피부과학회 1984 대한피부과학회지 Vol.22 No.3

A retrospective study was made of the medical records of 114 pregnant women with untreated syphilis and their offsprings, and 19 pregnant women with treated syphilis and their offsprings at Severance Hospital, Yonsei University College of Medicine during the years 1972 through 1981. We analyzed the outcornes of offsprings from both untreated and treated syphilitic mothers and the clinical manife- stations of early congenital syphilis. The results obtained were as follows: Of 30 offsprings from 30 untreated syphilitic mothers with VDRL titer below 1: 4, six(20%) had congenital syphilis, one(3%) was a stillbirth, and twenty-three were normal infants. Of 84 offsprings from 84 untreated syphilitic mothers with VDRL titer above 1: 8, fifty-six(67g) had congenital syphilis, ten(12g,) were neonatal deaths, and eighteen(21%) were stillbirths, Normal infants were not observed. The mean weight ratio of placenta to fetus was 0 29 in g8 offsprings from syphilitic mothers. The ratios were as follows: 0. 25 in 14 living infants with con- genital syphilis, 0. 27 in 5 neonatal deaths, and (), 33 in 19 stillbirths respectively. 3, Of 19 pregnant women with treated syphilis, the qualitative tests of VDRL were all reactive except for one case and the quantitatis e tests of VDRL were 1: 1 weakly reactive to 1: 4 reactive. FTA-ABS tests demonstrated reactive results in all cases. The qualitative tests of VDRL in the infeants of the treated mothers were 1: 1 weakly reactive to 1: 2 reactive and FTA-ABS tests were reactive in all cases.-countinue-

젊은 여성 피부색의 부위별 차이 및 계절적 변화에 관한 연구

이성낙(Sung Nack Lee),박윤성(Yoon Sung Park),이해을(Hae Eul Lee),조정구(Chung Koo Cho) 대한피부과학회 1985 대한피부과학회지 Vol.23 No.2

Sixty-five volunteers whose skin had never been tanned intentionally participated in this experiment. The skin colors of extensor and flexor of forearm, fore- head, and cheek were measured with Color and Color Difference Meter(Nippon Denshoku Kogyo Co. CP6R 1001-DP) which represents .kin color as 'L, a, and b in values. The L, a', and b values mean the degree of ligntness, redness, and yellowness respectively. Measurement has been performed seven times repeatedly in a year at regular intervals. From the study, the following results were obtained. ]'lexor skin of forearm showed the highest lightness in a year compared to the other regions. All of the regions examined showed the highest lightness in spring compared to the other seasons. 3. Cheek skin showed the highest redness among the four checked regions in a year. 4, All of the checked regions showed the higher redness in summer than in spring. and autumn. 5 All of the checked regions showed the lowest yellowness in May.

Imidazole유도체 및 Griseofulvin의 항진균력에 대한 실험적 연구

진홍상(Hong Sang Chin),이광훈(Kwang Hoon Lee),조정구(Chung Koo Cho) 대한피부과학회 1984 大韓皮膚科學會誌 Vol.22 No.2

The present study was designed to obtain omparative data on in vitro antifungal activities of imidazole derivatives. Minimum inhibitory oncentrations of clotrimazole, miconazole, econazole, ketoconazlole and griseofulvin on 4 strains of Trichophyton mentagrophytes, 3 strains of Trichophyton rubrum, 2 strains of Microsporum canis and ] strain of Sporothriv: schenckii were etermined after 3 week' incubation at room temperature on Sabouraud's dextrose liquid media. In addition, the fungicidal activities of miconazole and econazole were tested against Z'richophyton mentagrophytes and Microsporum canis, using the techniques described by Vanbreuseghern(1967) The results are summarzed as follows: ] In most of the dermatophytes studied, 1 to 10 pg/ml of M1C were detected. Diverse susceptibility pattern was observed among different fungal species, but no or minor variability was noted within the same species. The susceptibility of Z'ri- chophyton rubrum showed at MIC of 0. 01 to 10 pg/ml, T ichophyton mentagro- phyt.es and Mic osporum canis at 0. 1 to 10 pg/ml and 0. 1 to 1000 gg/ml respec- tively. The Trichophyton rubrum was the most sensitive. In the susceptibility test of Sporothrix schenckii, the high resistance to clotrimazole and griseofuhin was observed. The fungistatic activities of miconazole, econazole and ketoconazole were observed only at concentrations higher than JpQ pg/ml.

Maffucci's Syndrom -1例

김남현(Nam Hyun Kim),김형길(Hyung Kil Kim),조정구(Chung Koo Cho),김지호(Ji Ho Kim) 대한정형외과학회 1978 대한정형외과학회지 Vol.13 No.4