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단기간 고강도 저항운동 후 테스토스테론, IGF-1과 염증지표의 변화 연구
김재호(Kim, Jea-Ho),고영준(Ko, Young-Jun),조원제(Cho, Won-Je) 한국체육과학회 2015 한국체육과학회지 Vol.24 No.4
In this study, male adults were asked to perform a 6-weeks high intensity resistance exercise to observe the changes in testosterone, IGF-1 and blood inflammatory factors(CRP, CPK, IL-6) by exercise intensity and period. The male students in their 20’s who are currently attending the D university located in Y-si, Gyeonggi-do were participated in this study. 10 participants were assigned into a control group(CG), 10 participants were assigned into intense resistance exercise group(RTG). The participants were asked to perform the exercise for a 6-week short, 3 times a week. No exercise was given to control group. The intense exercise group was asked to perform 5 sets 70-80%RM, 3 to 8 repetitions per a set. Repeated measure ANOVA SPSS Ver. 18.0 statistics program was used to describe all data statistically. Then Repeated measure ANOVA was performed to confirm the group, period and interaction, whereas paired t-test was used to validate the difference between the groups by time. And different between CG and RTG was independent t-test after exercise treatment. As a result, the significant difference was shown on IGF-1, blood inflammatory factors in RTG pre to post. The difference in IL-6 was observed between the groups. The interaction was observed in blood inflammatory. So In correlation analysis about testosterone, IGF-1 and inflammatory factors after the short-term high-intensity resisted exercise, CPK and IL-6 showed positive correlation. Therefore, high intense resistance exercise was shown to have a positive impact on IGF-1, blood inflammatory factors, the exercise needs to be carefully prescribed considering the individual characteristics.
정병호(Byung Ho Chung),조원제(Won Jea Cho),천승훈(Seung Hoon Cheon),박면지(Myun Ji Park),유진철(Jin Cheol Yoo),천문우(Moon Woo Chun) 대한약학회 1997 약학회지 Vol.41 No.2
For the development of antifungal agents, modification of naftifine which exhibits significant antimycotic activity was performed by replacing the naphthalene ring of it to hetero cyclic rings such as morpholine. benzothiazole, piperidine and pyridine derivatives. The synthesized compounds were tested in vitro antifungal activity against five different fungi with naftifine as a comparative antimycotic molecule. From the biological evaluation two compounds, (E)-N-(3-phenyl-2-propenyl)-N-(4-piperidinylmethyl)amine(3d) and (E)-N-(3-phenyl-2-propenyl)-N-(3-pyridylmethyl)amine(3f) showed relatively noticeable activity(MIC=50mcg/ml). On the other hand, the other compounds had no activity.
도희정(Hea Jeong Doh),조원제(Won Jea Cho),용철순(Chul Soon Yong),이치호(Chi Ho Lee),김대덕(Dae Duk Kim) 한국약제학회 2001 Journal of Pharmaceutical Investigation Vol.31 No.2
N/A Various alkyl ester prodrugs of diclofenac were synthesized in order to investigate the relationship between their skin permeation characteristics and physicochemical properties. Solubility in various vehicles was measured at room temperature. 1-Octanol/water partition coefficients (Log P) and capacity factors (k^1) were measured to determine the lipophilicity of the prodrugs. Stability of prodrugs in the skin extract and homogenate was also investigated before conducting the skin permeation studies. Increases in the Log P and capacity factor values were observed when alkyl esters of diclofenac were prepared. Since the aqueous solubility of the prodrugs was not high enough, they were saturated in propylene glycol (PG) for skin permeation studies. Prodrugs were rapidly metabolized to diclofenac, both in skin homogenate and in dermal extract of skin. The skin permeation rate of alkyl ester prodrugs was significantly higher than diclofenac with shorter lag time. Moreover, a parabolic relationship was observed between the permeation rate and the log P values of prodrugs, and the maximum flux was achieved at a log P value of around 4.0.
3-페닐-1-이소퀴놀린아민이 신경세포에서 베타 아밀로이드 전구단백질의 대사에 미치는 영향
임재윤(Jae-Yoon Leem),조원제(Won-Jea Cho) 대한약학회 2010 약학회지 Vol.54 No.6
Alzheimer's disease (AD) is characterized pathologically by the presence of intracellular neurofibrillary tangles and deposition of β-amyloid (Aβ) peptides, which are generated by processing of amyloid precursor protein (APP). It is urgent to develop effective therapies for the treatment of AD, since our society rapidly accelerate aging. Aβ peptides have been believed to be neurotoxic and now are also considered to have effects on the mechanism of memory formation. Recently, we investigated that a quinoline compound from natural product reduced the secretion of Aβ from the neuroblastoma N2a cells (NL/N cell line) overexpressing APPswe. In this study, 3-phenyl-1-isoquinolinamine, a synthetic isoquinoline compound was analyzed to determine its effects on the metabolism of APP. It inhibited the secretion of Aβ peptides from the N2a NL/N cell line. Beta-site APP cleaving enzyme (BACE) fluorescence resonance energy transfer (FRET) assay revealed that it inhibited BACE activity in a dose dependent manner. Immunoblotting study showed that it inhibited APP stabilization and expression and it slightly increased the stablization and the expression of γ-secreatase component from the N2a NL/N cell line. We suggest that 3-phenyl-1-isoquinolinamine inhibits APP metabolism and Aβ generation by the means of BACE inhibitory mechanism. This is the first report that 3-phenyl-1-isoquinolinamine inhibits the secretion of Aβ peptides from neuroblastoma cells.
정병호(Byung Ho Chung),엄춘성(Chun Sung Eam),조원제(Won Jea Cho),천승훈(Seung Hoon Cheon) 대한약학회 1999 약학회지 Vol.43 No.3
Six novel aryl alkanoic acid derivatives as potential nonsteroidal antiinflammatory and analgesic compounds, were prepared through consecutive reactions of Ullman ether synthesis, NaBH4 reduction, bromination, SN2 reaction with nitrile and alkaline hydrolysis of the nitrile.
항암제 안티네오플라스톤 A10의 동족체합성 및 항암 활성
최보길(Bo Gil Choi),서희경(Hee Kyoung Seo),김옥영(Ok Young Kim),정병호(Bung Ho Chung),오인준(In Jun Oh),조원제(Won Jea Cho),천승훈(Seung Hoon Cheon),박민수(Min Soo Park),최상운(Sang Un Choi),이정옥(Chong Ock Lee) 대한약학회 1997 약학회지 Vol.41 No.3
Some analogs and their Mannich bases of Antineoplaston A10 (A10) were synthesized. Chemical yield for the 2-(or 3-)thienyl, benzol, and phenylpropionyl analogs were high but 1-naphthyl analog was synthesized in low yield. the Mannich bases formation of these analogs with morpholine went verywell compared to other bases. 1-Naphthyl, 4-nitrobenzoyl, and phenylpropionyl analogs of A10 showed weak in vitro activity but the other A10 analogs showed weaker or no activity at 10-1000mcg/ml. But their Mannich bases containing A10analogs showed good in vitro activity compared to simple A10 analogs.
연구논문 : 의약화학 ; 2,4,6-치환 피리딘 유도체의 합성, topoisomerase 1 억제능 및 구조-활성 관계 연구
조룡현 ( Long Xuan Zhao ),문윤수 ( Yoon Soo Moon ),알준바스넷 ( Arjun Basnet ),김은경 ( Eun Kyung Kim ),장영동 ( Yurng Dong Jahng ),박재규 ( Jae Gyu Park ),정태천 ( Tae Cheon Jeong ),조원제 ( Won Jea Cho ),최상운 ( Sang Un Choi ) 영남대학교 약품개발연구소 2004 영남대학교 약품개발연구소 연구업적집 Vol.14 No.-