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Ranitidine과 Famotidine이 Theophylline 대사에 미치는 영향의 약동학적 비교연구
조상헌 ( Sang Heon Cho ),조영주 ( Young Joo Cho ),김미경 ( Mi Kyeong Kim ),권오정 ( O Jung Kwon ),이춘택 ( Choon Taek Lee ),이상도 ( Sang Do Lee ),민경업 ( Kyung Up Min ),김유영 ( You Young Kim ),김호순 ( Ho Soon Kim ),신현택 ( Hy 대한결핵 및 호흡기학회 1990 Tuberculosis and Respiratory Diseases Vol.37 No.1
기관지천식 가이드라인의 변화 2006 개정 GINA 가이드라인 중심
조상헌 ( Sang Heon Cho ) 대한내과학회 2007 대한내과학회지 Vol.72 No.3
Asthma is a serious global health problem. People of all ages in countries throughout the world are affected by this chronic airway disorder that, when uncontrolled, can place severe limits on daily life and is sometimes fatal. The prevalence of asthma is increasing in most countries, especially among children. Asthma is a significant burden, not only in terms of health care costs but also of lost productivity and reduced participation in family life. In 2002, the GINA Report stated that it is reasonable to expect that in most patients with asthma, control of the disease can, and should be achieved and maintained. To meet this challenge, in 2005, Executive Committee recommended preparation of a new report not only to incorporate updated scientific information but to implement an approach to asthma management based on asthma control, rather than asthma severity. Recommendations to assess, treat and maintain asthma control are provided in the new GINA Report revised in 2006. Here, we summarize the main concepts and major changes of the new GINA guideline. (Korean J Med 72:245-255, 2007)
조상헌 ( Sang Heon Cho ) 대한내과학회 2009 대한내과학회지 Vol.76 No.3
Cough is an important defensive reflex of the respiratory tract needed to clear and protect the airways; however, it may become exaggerated and interfere with quality of life. Chronic cough is one of the most common symptoms leading to referral to secondary or tertiary hospital. The purpose of this article is to review the most common causes of chronic cough and to provide a comprehensive algorithms for clinician in evaluating and treating the patient with chronic cough. After excluding the possibility of smoking, angiotensin converting enzyme inhibitor or other specific abnormality in chest radiography as a cause of chronic cough, upper airway cough syndrome (UACS), previously named as postnasal drip syndrome, asthma, nonasthmatic eosinophilic bronchitis (NAEB), and gastroesophageal reflux disease (GERD) are the most common causes of chronic cough and these conditions may be present alone or in combination. Chronic cough can be cured in most people by treatment of these underlying causes of chronic cough. (Korean J Med 76:252-259, 2009)
조상헌 ( Sang Heon Cho ),김윤근 ( Yoon Keun Kim ),손지웅 ( Jee Woong Sohn ),이병재,김우경 ( Woo Kyung Kim ),이상록 ( Sang Fok Lee ),박재경 ( Jae Kyung Park ),민경업 ( Kyung Up Min ),하미나 ( Mi Na Ha ),안윤옥 ( Yoon Ok Ahn ),지영구 ( 대한천식알레르기학회 1999 천식 및 알레르기 Vol.19 No.3
Background: Allergic rhinitis and asthma are the most prevalent allergic diseases and a num- ber of studies have shown an increase in prevalence of both diseases all over the world in recent years. Although we reported the asthma prevalence in Korea, little is known about the prevalence of rhinitis in Korea. Objective: The purpose of this study was to elucidate the prevalence of childhood rhinitis including allergic and non-atopic rhinitis in Korea. Methods: We performed questionnaire survey and allergy skin prick test with 10 common inhalant allergens among 3,219 subjects aged 7-19 years in Seoul and Chungju. Subjects were asked whether they were troubled by sneezing, runny nose, itchy nose and/or nasal blockage in the last year, which were not related to common cold. Rhinitis was diagnosed when the subjects complained of 3 or more symptoms on questionnaire. Skin-prick test was regarded as positive when the wheal caused by allergen was same or larger than that caused by histamine. Results: The average prevalence of rhinitis was 13.0%. We could not find any significant age or sex differences in the prevalence of rhinitis. There was no regional difference between Seoul (12.7%) and Chungju (13.2%). The positive rate of skin prick test in subjects with rhinitis was 59.6%, which means the prevalence of allergic rhinitis was 7.8% and that of non-atopic rhinitis was 5.2%. The common allergens of allergic rhinitis were Dermatophagoides farinae (62.5%), Dematophagoides pteronyssinus (55.8%), cat fur (46.9%), cockroach (18.9%) and mugwort pollens (10.1%). Conclusion: The prevalence of childhood rhinitis in Korea was 13.0% and those of allergic rhinitis and non-atopic rhinitis was 7.8% and 5.2%, respectively.
집먼지진드기 항원 - 특이 T - 세포 클론에서 추가 자극에 따른 IL - 4 , IL - 5 , IFN - r mRNA 발현양상의 변화
조상헌(Sang Heon Cho),홍수종(Soo Jong Hong),김윤근(Yoon Keun Kim),박재경(Jae Kyung Park),심정연(Jung Yeon Shim),문희범(Hee Bom Moon),민경업(Kyoun Up Min),김유영(You Young Kim) 대한천식알레르기학회 1998 천식 및 알레르기 Vol.18 No.4
Background: It is known that immunotherapy promotes the development of allergen-specific Thl-like lymphocytes whose products are effective in inhibiting clinical response of sensitized atopic patients to allergen exposure. At the single cell level in short term culture, however, IL-4 and IL-5 are co-expressed, while IL-4 and IFN-y are exclusively expressed. Objective. IL-4, IL-5, and IFN-y mRNA were measured in Der pI-specific T-cell clones (TCCs) to evaluate whether expression of cytokine in allergen-specific TCC is fixed regardless of stimuli. Methods: Seven Der pI-specific TCCs were made from two asthmatics sensitive to D. pteronyssinus. IL-4, IL-5, and IFN-y mRNA were measured by RT-PCR in these TCCs after antigen-specific (Der pI) and nonspecific (PHA + TPA) stimuli. Results: IL-4 and IL-5 mRNA were expressed in four and six of seven TCCs, but IFN-y mRNA was not expressed in any TCCs after Der pI-specific stimuli. Meanwhile, after the stimulus of TPA plus PHA, IFN-y mRNA as well as IL-4 and IL-5 mRNA were expressed in four of seven TCCs, and in one TCC, only IFN-y mRNA was expressed without expression of IL-4 mRNA. Conclusion: The expression of cytokine may be variable in allergen-specific TCC according to the type and amount of stimuli.
한국인 성인 천식 한자의 Theophyline 대사에 관한 약동학적 연구
조상헌(Sang Heon Cho),조영주(Young Joo Cho),민경업(Kyung Up Min),김유영(You Young Kim),김호순(Ho Soon Kim),신현택(Hyun Taek Shin Pharm) 대한내과학회 1991 대한내과학회지 Vol.41 No.4
To evaluate pharmacokinetic parameters and maintenance dose of theophylline in Korean adult asthmatics, we estimated total body clearance by nonlinear computer analysis according to age and sex after continuous infusion of aminophylline in 82adult asthmatics (age range 20-81 years old). Eight men were smokers. In nonsmoking male and female patients, the total body clearance of patients over 55years old was significantly lower than that of patients under 55years old(p<0.05). In nonsmoking male patients, the total body clearance was 44.2±9.9 ml/hour/kg in patients under 55years old and 33.2±8.2 ml/hour/kg in patents over 55years old. In nonsmoking female patients, it was 44.1±13.6ml/hour/kg in patients under 55years old and 34.1±8.2 ml/hour/ kg in patients over 55years old. The regression equations between total body clearance and age were total body clearance (ml/hour/kg)= 0.403×Age+59.698 in male (r=0.50, p<0,05) and 0.546×Age+67.462 in female (r=0.61, p<0.05). The total body clearance of smoking male was increased by 27% compared to that of nonsmokers of same age group. There was no significant diference between clearance of Korean adult asthmatics and that of western people reportec1 by Hendeles and Antal. And there was no difference according to gender in same age groups. Even though we can calculate serum theophylline concentration from above equations, variability of total body clearance is so wide that regular estimation of serum theophylline concentration is recommended.