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정상 및 임신성 당뇨병 임신부의 임신 중 체중 증가량와 신생아 체중
김문영(Moon Young Kim),양재혁(Jae Hyug Yang),장학철(Hak Chul Jang),박정은(Jung Eun Park),임창훈(Chang Hoon Yim),정호연(Ho Yeun Chung),한기옥(Ki Ok Han),윤현구(Hyun Koo Yoon),한인권(In Kwon Han),김미정(Mi Jeong Kim),한혜경(Hye Kyung H 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.4
N/A Objective : The purpose of this study was to determine the independent factors that predict neonatal birthweight and find the relationship between maternal weight gain and neonatal birthweight in women with normal glucose tolerance (NGT) and gestational diabetes mellitus (GDM). Methods : Forty-six women with GDM and one hundred fifty women with NGT were included in the study. All subjects had singleton pregnancies and no medical diseases that may affect the fetal growth and were certain of gestational age by early ultrasonography. Maternal weight at each prenatal visit was recorded and neonatal anthropometic measurement was done within 2 days of birth. Results : The average rate of weight gain (kg/week) in NGT was lowest during the first trimester (0.09±0.10), peaked during the second trimester (0.52±0.14), and slowed after 34 gestational weeks (0.46±0.26). In women with GDM, the average rate of weight gain was also lowest during the first trimester (0.18±0.23), but it was twofold higher compared with women with NGT. There was a significant decrease of the rate of weight gain after 28 gestational weeks in women with GDM. Total weight gain during pregnancy was 3.4 kg less in women with GDM. Neonatal birthweight was correlated with maternal weight gain and the rate of weight gain during 14-27 and 28-33 weeks in NGT. However, birthweight was correlated with maternal weight gain and the rate of weight gain during the first trimester and 14-27 weeks in GDM. Conclusion : This result suggests that the women with GDM who have greater weight gain during the first and the second trimester have a increased risk of excessive fetal growth. Thus strict glycemic control during pregnancy is needed especially in these women.
G 단백질 변이를 동반한 McCune - Albright 증후군 1 예
민헌기,윤현구,한인권,장학철,임창훈,박찬문,한기옥,강영순,문인걸,홍성란,정필호,황정규,김윤이,황지주,정호연 대한내분비학회 1999 Endocrinology and metabolism Vol.14 No.4
McCune-Albright syndrome (MAS) is a sporadic disease classically including polyostotic fibrous dysplasia, cafe -au-lait spots, sexual precocity, and other hyperfunctional endocrinopathies. Recent investigations suggest an etiological role for activating embryonic somatic missense mutations in the gene for the a subunit of Gs (Gsa), the G protein that stimulates adenylyl cyclase. DNA from bone, ovary, and blood was analyzed by using polymerase chain reaction and sequenced. A embryological somatic mutation of Gsa gene encoding substitution of a Cys for Arg at amino acid 201 from cells of dysplastic bone and ovary was observed, and the distribution of mutant gene reveals mosaic pattern. We report a case of McCune-Albright syndrome with an activating mutation at codon 201 of Gsa subunit on ovary and bone tissue that was experienced recently(J Kor Soc Endocrinol 14:779-785, 1999).