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鄭泰天 최신의학사 1969 最新醫學 Vol.12 No.12
The reported case was a 26 years old Korean woman. She had amenorrhea and distention of the abdomen. After the date of confinement, she had not complained the pain. X-ray reading showed spontaneous death of the fetus, and finding of uterus bicornis un.icolis. After laparotomy, she had malbilding of uterus and pregnancy of 8th month of rudimentary right horn of uterus.
1966年度 全北金堤郡에서 報告된 類似夏季腦炎患者 豫後 및 後遺症에 關한 調査硏究
金康湜,李煜鉉,金熔泰,鄭泰天,林就範,權致五 최신의학사 1968 最新醫學 Vol.11 No.10
The investigation was aimed at finding out. the status of prognosis and sequelae of Japanese B type encephalitis which 'is the most serious epidemic infectious disease in Korea. Among the total 216 cases reported as encephalitis patients in Kimjae-gun, Cholla pukdo in which the largest number of encephalitis cases were reported in Korea in 1966, this survey was carried out on 201 cases whom we able to contact and examine from 6. September to 8 Sespt. 1967, about 1 year after the encephalitis epidemic 'i of 1966. The following results were obtained. 1. Case distribution by sex and age: E f,- Of the 201 cases investigated, 51.2 per cent were in male and 48.8 per cent were in female: The age group - from 3 to 7 years constituted 80.$ per cent and from 1 to 10 years constituted 96.6 per cent of cases. Susceptible I age group appeared to be in younger age group compared with those of the past encephalitis epidemics. 2. Case fatality: Case fatality rate was 36.9 per cent for male, 31.6 per cent for female and 34.3 per ' cent for total. Case . j fatality rate for male was slightly higher than that of female. 3. Frequency of sequelae by age:. j. There appeared to be no predilection by age. It was found that 50 per cent of cases of survivors had one or several kinds of sequelae. 4. Frequency of sequelae by duration between the onset and beginning of treatment: No special tendency was found by length of duration between the onset and beginning of treatment. 5. Frequency of sequelae by length of treatment: High frequency rate of sequelae was seen on the cases who treated longer which indicate more severe case.
Hepatoprotective effects of Platycodon grandiflorum on acetaminophen-induced liver damage in mice
Lee, Kyung Jin,You, Ho Jin,Park, Sung Jun,Kim, Young Sup,Chung, Young Chul,Jeong, Tae Chun,Jeong, Hye Gwang 영남대학교 약품개발연구소 2002 영남대학교 약품개발연구소 연구업적집 Vol.11 No.-
The protective effects of an aqueous extract from the roots of Platycodon grandiflorum A. DC (Campanulaceae), Changkil (CK), on acetaminophen (APAP)-induced hepatotoxicities and the possible protective mechanisms involved were investigated in mice. Pretreatment with CK prior to the administration of APAP significantly prevented the increase in serum alanine aminotransferase and aspartate aminotransferase activity and hepatic lipid peroxidation in a dose-dependent manner. APAP-induced hepatotoxicity was also essentially prevented as evidenced by liver histopathology. Hepatic glutahione levels and glutathione-S-transferase activities were not affected by treatment with CK alone, but pretreatment with CK protected the APAP-induced depletion of hepatic glutathione levels. The effects of CK on cytochrome P450 (P450) 1A2 and 2E1, the major isozymes involved in APAP bioactivation, were investigated. In microsomal incubations, CK effectively inhibited P450 1A2-dependent methoxyresorufin O-deethylase activities and the P450 2E1-dependent p-nitrophenol and aniline hydroxylase. The results suggest that the protective effects of CK against the APAP-induced hepatotoxicity may, at least in part, be due to its ability to block P450-mediated APAP bioactivation.