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제5차 대한간학회 춘계학술대회 초록집 : C형 간염 바이러스로 인한 만성 간질환 환자에서 HCV-RNA의 유전자형에 관한 연구
이철종 ( Lee Cheol Jong ),신우원 ( Sin U Won ),안현숙 ( An Hyeon Sug ),이성욱 ( Lee Seong Ug ),노명환 ( No Myeong Hwan ),한상영 ( Han Sang Yeong ),최석렬 ( Choe Seog Lyeol ),정진숙 ( Jeong Jin Sug ) 대한간학회 1999 Clinical and Molecular Hepatology(대한간학회지) Vol.5 No.1(S)
부산지역 한 3차 병원으로 내원한 폐결핵 환자에서 약제 내성률과 예측인자간의 연관성
손춘희 ( Son Chun Hui ),양두경 ( Yang Du Gyeong ),노미숙 ( No Mi Sug ),정진숙 ( Jeong Jin Sug ),이혁 ( Lee Hyeog ),이기남 ( Lee Gi Nam ),최필조 ( Choe Pil Jo ),이수걸 ( Lee Su Geol ),장광열 ( Jang Gwang Yeol ),최익수 ( Choe Ig Su 대한결핵 및 호흡기학회 2001 Tuberculosis and Respiratory Diseases Vol.51 No.5
cDNA microarray를 이용한 위선암에서의 유전자 발현에 관한 연구
이종훈 ( Lee Jong Hun ),최석렬 ( Choe Seog Lyeol ),황태호 ( Hwang Tae Ho ),김민찬 ( Kim Min Chan ),정갑중 ( Jeong Gab Jung ),노미숙 ( No Mi Sug ),정진숙 ( Jeong Jin Sug ) 대한소화기학회 2003 대한소화기학회지 Vol.42 No.6
Background/Aims: cDNA microarray provides a powerful alternative with an unprecedented view scope in monitoring gene expression levels and leads to discoveries of regulatory pathways involved in complicated biological processes. Our aim was to explore the different gene expression patterns in early and advanced gastric cancer. Methods: By using a cDNA microarray representing 4,608 cDNA clusters, we studied the expression profiling in 10 paired gastric adenocarcinoma samples and the adjacent noncancerous gastric tissues. The alterations in gene expression levels were confirmed by Northern blot and reverse-transcription (RT) PCR. Results: Genes that were differently expressed in cancer and noncancerous tissues were identified. Forty-four and 92 (26 and 43 of them were known, respectively) genes or cDNA were up- and down-regulated, respectively, in more than 80% of gastric adenocarcinoma samples. The semi-quantitative RT-PCR results were consistent with the microarray findings. To distinguish between early and advanced gastric cancers, we used a supervised learning classification approach. When we used 16 and 20 genes as predictors, the prediction was all yielded statistically significant. Moreover, when we used 9 genes, we could predict with the highest accuracy. Conclusions: These results may provide not only a new molecular basis for understanding biological properties of gastric adenocarcinoma, but also useful resources for future development of therapeutic targets and diagnostic markers for gastric adenocarcinoma. (Korean J Gastroenterol 2003;42:484-495)