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항히스타민제의 대리결과변수로서 히스타민에 의한 피내주사반응 유용성에 대한 고찰
한나영, 송병정, 백현문, 정에벤, 유영훈, 전지현, 구성우, 윤휘열, 권광일 충남대학교 약학대학 의약품개발연구소 2017 藥學論文集 Vol.32 No.-
In this study, it is reviewed that histamine-induced wheal and flare responses are potential sur-rogate endpoints for predicting the clinical effects of antihistamines in patients with allergic skin diseases. Histamine plays an important role in allergic response by inducing degranulation of mast cells due to allergen exposure and mediating the inflammatory reaction. Thus, suppression of histamine-induced wheal and flare has been noted as surrogate markers for efficacy of Hl receptor antagonists. In addition, allergy skin prick test and intradermal test using histamine have been used to diagnose the histamin-induced allergic reaction. However, it has been well known that allergic diseases are not only mediated by histamine. but also by var-ious immunological inflammatory responses. Previous studies reported that there is a lack of evidence about the correlation between antihistamines to predict clinical efficacy and antihistamine efficacy, although hista-mine-induced wheal and flare responses may be useful indicators of the dose-response relationship. In con-clusion, the evaluation for the suppression of wheal and flare after histamine injection is reasonable for de-termining the treatment of allergic simple skin diseases, but there is a limit to evaluate the efficacy in com-plex inflammatory diseases mediated IgE or T cells, or other immune complex. Therefore, further studies are needed to identify additional surrogate endpoints to predict the therapeutic effect of antihistamines in other inflammatory diseases such as allergic rhinitis, atopic conjunctivitis, allergic asthma, and so on.
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유영훈,송병정,백현문,이재연,정성미,황시영,정에벤,Sudeep Pradhan,윤휘열,권광일 충남대학교 약학대학 의약품개발연구소 2016 藥學論文集 Vol.31 No.-
Getting the spotlight to traditional medicine recently, the number of adverse effect and drug-drug interaction of traditional medicine is increased. For this reason, pharmacokinetics study of traditional medicine need to scientific prove of safety and effectiveness. The method of pharmacokinetics study of traditional medicine, Botanical drug guideline of U.S. FDA recommend to measure analytical marker concentration in blood. The aim of this study is quantitative content analysis of analytical marker in citrus unshiu peel for help pharmacokinetics study of traditional medicine. We seleceted naringin, naringenin, hesperidin and hesperetin as analytical marker and used HPLC-MS/MS as analysis equipment. Internal standard (IS) is domperidone. The mass transition of hesperidin, hesperetin, naringin and naringenin were 609.4 → 300.9, 301.0 → 285.8, 579.23 → 270.9 and 271.0 → 150.8 respectively. The result of this study is that 1g citrus unshiu peel has 12.24 mg (1.224%) hesperidin, 0.66 mg (0.066%) hesperetin, 15.17 mg (1.517%) naringin, and naringenin was not detected. citrus unshiu peel analytical marker that we can detect is naringin, naringenin, hesperidin. We could confirmed amount of citrus unshiu peel analytical marker through this study and our data further support the pharmacokinetics study of traditional medicine.
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