http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
철과 철 경화제가 마우스의 Vibrio vulnificus 패혈증에 미치는 영향
하범석(Bom Seock Ha),정선식(Sun Sik Chung),이준행(Joon Haeng Lee),김영표(Young Pio Kim) 대한피부과학회 1989 대한피부과학회지 Vol.27 No.4
Infection with V. vulnificus resulting in septicemia accompanied with skin gangrene and high mortality of 50% or more freqently occurs in people with liver disenses. And it has also been demonstrated that serum iron, essential to the growth of microorganisms, has been elevated in liver damaged animals. In spite of many efforts to reveal the pathogenesis of this fatal disease, there is no clear conclusion so far. Significant increase or decrease in LD of V. vulnificus (CDC C7184) was observed when mice were treated with ferric arnmonium citrate (FAC) and a specific iron chelator, desferal(Df), originated from Streptomyces pilosus and a broad spectrurn cation chelator, calciurn disodium ethylenediaminetetraacetate (CaEDTA) widly used in heavy metal poisoning treated alone or in combination. The results were obtained as follows. FAC and Df lowered LD to approximately 1.96x 10 colony forming unit (CFU) and 9.77x10 CFU respectively from 4.46 x 10 CFU, LDso of the control group. However, CaEDTA elevated the I D to 4.97 X 10 CFU. The LD of the group administered FAC and Df simultaneously was about 9.28x10' CFU. Whereas, the LD of the group administered FAC and CaEDTA simultaneously was approximately 7.88 x J.O similar to that of the control group. This study demonstrates that there is a close association of the iron with V. vulnificus septicemia and Df lowers LD of the rnice. CaED7A, however, elevated the LD. The author hereby proposes carefully iron chelators such as CaEDTA as an agent for a new adjuvant therapy of the V. vulnificus septicernia.