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RISS 인기검색어
- 검색키워드
- 저자 : 정상립 ( Jeong Woo Lee (검색결과 3 건)
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경표피수분손실 및 Methyl Nicotinate 경피흡수에 의한 혈관 반응 측정을 이용한 피부 장벽 기능 검사
이정우,김도원,전재복,정상립 ( Jeong Woo Lee,Jae Bok Jun,Do Won Kim,Sang Lip Chung ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.6
Background: The measurement of transepidermal water loss(TEWL) is widely used in evaluating the stratum corneum barrier function. It is also possible to evaluate the penetration of substances into the skin as an adc'itional parameter of the straturn corneum barrier function. Objective : The purpose of the present study is to investigate ihe relat,ionship between TEWL and t,he percutaneous absorptic n of met,hyl nicotinate(MN) in the normal and acute perturbative state of the epidermal barrier. Method: Vascular response 10 MN penetration were rneasured by both laser Doppler flowmetry (LDF) and visual erythema oii the forearms of 30 healthy volunteers. Stratum corneum of the ar ea of 2*10cm on the volar for earm was removed by repeated tape stripping when TEWL reached 12-30g/rnh measured with Evaporimeter. The left forearm received no treatrnent as a control site. Each time the profile of the vascular response to MN penetration was analysed using the following parameters.the 1; g time between MN application and initial response(T0), the time between MN application and maximal response(Tmax), and the rnaximal response(LDF), the time between MN application and initial visual erythema(VT0), and the time between MN application and maxirnum visual erythema(VTmax). Results : The data showed a negative correlation between TEWL and T0(r=-12.89, p<0.001), TEWL and Tmax=(r=-14.87, p< 0.001), and TEWL and VT0>(r= -3.99, p<0.001), TEWL and VTmax(r = -9.29, p<0.001). And there was a positive correlation between VT0 and T0(r=1.19, p<0.001), and between VTmax and Tmax(r=1.05, p<0.001). However, there was no detectable correlation between TEWL and LDFmax(p>0.05). Conclusion : Vascular response to percutaneous absorption of MN measured by LDF as well as TEWL is a useful non-invasiv method for objective evaluation of the stratum corneum barrier function. In addition, visual erit,hema induced by t,opical vasodilators such as MN is also a good method for skin barrier function assessment. (Korean J Dermatol 1997;35(6): 1121 1129)
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Nail Lacquer 가 Transonychial Water Loss에 미치는 영향
김도원,백승혜,이정우,정상립 ( Do Won Kim,Seung Hye Paek,Jeong Woo Lee,Sang Lip Chung ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.1
Background: Nail lacquer strengthens and protects the nail plate by preventing excess loss of moisture and providing a hard surface. On the other hand, it may produce allergic contact and irritant dermatitis, paronychial and nail bed inflammation and infection, dystrophic nails and onycholysis. Objective : The purpose of study was to investigate the effect of the nail lacquer on the barrier function of the nail. Methods : The study populatian consisted of 25 healthy young subjects who had not applied the nail lacquer to the nail for the last 3 months. Nail lacquer was applied to the left thumb and middle fingernail for 6 weeks and then removed by acetone. Transonychial water loss(TOWL) of the treated left fingernails and the untreated corresponding right fingernails was measured with an Evaporimeter. Lipids of the nails were extracted from distal nail cuttings and analysed by thin layer chromatography. Results . 1. Before application of the nail lacquer, there was no difference in TOWL between the left and right fingernails while the TOWL of the thumb nail was higher than that of the middle fingernail with a statistical significance(p<0.05). 2. The TOWL of the left fingernails, measured 1 day, 2, 4 and 6 weeks after application of the nail lacquer, was lower than that of the untreated right fingernails with a statistical significance( p< 0.05). 3. The TOWL of the left fingernails, measured 1, 3 and 7 days after removal of the nail lacquer by acetone, was not different statistically from that of the untreated right fingernails. 4. Lipid analysis demonstratcd that the cholesterol content was higher in the left fingernail which had been covered with nail lacquer than in the untreated right fingernail. 5. There was no clinical adverse effect observed during application of the nail lacquer or after removal of it. Conclusion : According to the results of the study, nail lacquer has some occlusive effects on transonychial water evaporatior . Because increased cholesterol content may be due to perturbations of barrier function , further studies of the effect of the nail lacquer on the barrier function of the nail will be needed. (Kor J Dermatol 1997 ; 35(1) : 82~89)
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Nail Lacquer가 Transonychial Water Loss에 미치는 영향
김도원,백승혜,이정우,정상립 경북대학교 의학연구소 1999 경북대학교병원의학연구소논문집 Vol.3 No.1
Background : Nail lacquer strengthens and protects the nail plate by preventing excess loss of moisture' and providing a hard surface. On the other hand, it may produce allergic contact and ir-ritant dermatitis, paronychial and nail bed inflammation and infection, dystrophic nails and only-cholysis. Objective : The purpose of study was to investigate the effect of the nail lacquer on the barrier function of the nail. Methods : The study population consisted of 25 healthy young subjects who had not applied the nail lacquer to the nail for the last 3 months. Nail lacquer was applied to the left thumb and middle fingernail for 6 weeks and then removed by acetone. Transonychial water loss(TOWL) of the treated left fingernails and the untreated corresponding right fingernails was measured with an Evaporimeter. Lipids of the nails were extracted from distal nail cuttings and analysed by thin layer chromatography. Results : 1. Before application of the nail lacquer, there was no difference In TOWL between the left and right fingernails while the TOWL of the thumb nail was higher than that of the middle fin-gernail with a statistical significance(p<0.05). 2. The TOWL of the left fingernails, measured 1 day, 2, 4 and 6 weeks after application of the nail lacquer, was lower than that of the entreated right fingernails with a statistical signifi-cance(p<0.05). 3. The TOWL of the left fingernails, measured 1, 3 and 7 days after removal of the nail lac-quer by acetone, was not different statistically from that of the untreated right fingernails. 4. Lipid analysis demonstrated that the cholesterol content was higher in the left fingernail which had been covered with nail lacquer than in the untreated right fingernail. 5. There was no clinical adverse effect observed during application of the nail lacquer or after removal of it. Conclusion : According to the results of the study, nail lacquer has some occlusive effects on transonychial water evaporation. Because increased cholesterol content may be due to perturba-tions of barrier function, further studies of the effect of the nail lacquer on the barrier function of the nail will be needed. (Kor J Dermatol 1997;35(1):82∼89)
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