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C-phycocyanin Attenuates Renal Inflammation and Fibrosis in UUO Mice
이강욱 ( Kang Wook Lee ),정사라 ( Sa Rah Chung ),정진영 ( Jin Young Jeong ),최대은 ( Dae Eun Choi ),나기량 ( Ki Ryang Na ),신영태 ( Young Tai Shin ) 대한신장학회 2010 Kidney Research and Clinical Practice Vol.29 No.6
It has been reported that Spirulina, a blue-green algae with potent antioxidant properties, affords significant protection against inflammation and fibrosis in the liver in vivo. The aim of the present study was to establish the possible protective role of C-phycocyanin, one of the active ingredients of Spirulina, in an experimental model of fibrosis in the kidney. Methods: The study was carried out using male C57BL6 mice. Mice were divided into the following four groups: sham-operated group; C-phycocyanin (PC)-treated sham group; unilateral ureteral obstruction (UUO) group; and PC with UUO group. We evaluated renal TGF-β mRNA, MCP-1, and osteopontin using real-time RT PCR. We evaluated renal TGF-β, α-SMA, and CD68 by immunohistochemistry. We recorded light microscopic findings of kidney specimens. Results: PC significantly decreased the expression of MCP-1 and α-SMA mRNA. Renal gene levels of expression of TGF-β, MCP-1, and osteopontin in the UUO group were significantly higher than the sham-operated group (p<0.01). The levels of expression of TGF-β, MCP-1, and osteopontin mRNA of kidneys in the PC-treated UUO group were significantly lower than the untreated UUO group (p< 0.05). The magnitude of expression of TGF-β and α-SMA protein in the kidneys of the PC-treated UUO group was significantly less than the untreated UUO control group (p<0.05). Conclusion: The results of the present study suggest that PC has anti-inflammatory and anti-fibrotic effects in an experimental UUO murine model.
이수윤 ( Soo Youn Lee ),김난희 ( Nan Hee Kim ),정사라 ( Sa Rah Jeong ),장동석 ( Dong Seok Jang ),이영모 ( Young Mo Lee ),나기량 ( Ki Ryang Na ),이강욱 ( Kang Wook Lee ),신영태 ( Young Tai Shin ) 대한내과학회 2007 대한내과학회지 Vol.73 No.2
목적: 연구자는 1995년 1월부터 2005년 6월까지 충남대학교병원 신장내과에서 치료적 혈장교환술을 시행 받은 신장질환 환자들을 대상으로 질환명과 이에 따른 임상양상 및 치료 결과를 알아보고자 하였다. 방법: 1995년 1월부터 2005년 6월까지 충남대학교병원 신장내과에 입원하여 혈장교환술을 시행한 23명의 환자를 대상으로 환자들의 의무기록을 후향적으로 검토하여 내원 시 주소, 기저질환, 임상경과, 병용치료 내용, 치료 결과를 조사하였다. 결과: 환자의 성별은 남자가 8예, 여자가 15예가 있었다. 질환별로는 혈전성 혈소판감소성 자반증 11예, 현미경적 다발성혈관염 7예, 루프스 신염 2예, 신이식후 급성체액성거부반응 2예, 세균성 심내막염에 병발된 급속진행성 사구체신염 1예. 11명의 혈전성 혈소판감소성 자반증 환자중 6명이 호전되었으며, 3명은 사망하였고, 2명은 ESRD로 진행하였다. 현미경적 다발성혈관염 7예 및 루프스 신염 2예 에서는 치료적 혈장교환술을 시행할 당시 폐출혈이 있었으며 혈장교환술을 시행후에 1예를 제외하고 모두 폐출혈의 호전이 있었다. 신이식후 급성 체액성거부반응 2명 중 1명은 혈장교환술 후에 호전되었고, 1명은 반응이 없어서 이식신을 제거하였다. 세균성 심내막염에 병발된 급속 진행성 사구체신염환자는 치료 후에 호전되었다. 부작용으로는 저혈압 3예, 소양증 2예, 오한 1예가 있었다. 결론: 혈장교환술은 혈전성 혈소판감소성 자반증 뿐 만 아니라 폐출혈을 동반한 ANCA 양성 혈관염과 루프스 신염의 치료에 효과가 있으며, 신이식 후 발생한 초급성 체액성 거부반응 및 이차성 급속 진행성 사구체신염의 치료로 고려할 수 있다. Background: Therapeutic plasma exchange (TPE) is a procedure by which plasma is removed from whole blood and this can be used in the treatment of some renal diseases. Methods: We reviewed the medical records for the chief complaints, underlying diseases, clinical courses and treatment outcomes of 23 patients who had been treated with TPE at the Renal Division of Chungnam National University Hospital from January 1995 to June 2005. Results: Patients with thrombotic thrombocytopenic purpura (TTP), microcopic polyangitis, lupus nephritis, hyperacute humoral rejection after kidney trasnplantation and rapidly progressive glomerulonephritis (RPGN) secondary to subacute bacterial endocarditis were included in this study. Among the 11 patients with TTP, six patients improved and two patients progressed to end-stage renal disease (ESRD). Three patients with TTP died. Seven patients with microscopic polyangitis and two patients with lupus nephritis had pulmonary hemorrhage at the time of TPE. Eight of the 11 TTP patients showed improvement of their pulmonary hemorrhage after TPE. One of the two patients with hyperacute humoral rejection after kidney transplantation and one patient with secondary RPGN were improved after TPE. Hypotension (three cases) was the most common adverse effect of TPE, followed by two cases of itching sensation and one case of fever with chills. Conclusions: Therapeutic plasma exchange was an effective treatment for patients with TTP, microscopic polyangitis, lupus nephritis with pulmonary hemorrhage and hyperacute humoral rejection after kidney transplantation. (Korean J Med 73:176-182, 2007)
증례 : 비기능성 뇌하수체 종양에 연관된 항이뇨호르몬 분비이상 증후군 1예
이준철 ( Jun Chul Lee ),권기현 ( Ki Hyun Kwon ),이인석 ( Ihn Suk Lee ),김윤정 ( Yun Jeung Kim ),정사라 ( Sa Rah Jeong ),김설영 ( Seul Young Kim ),구본정 ( Bon Jeong Ku ) 대한내과학회 2007 대한내과학회지 Vol.72 No.3
저자들은 저나트륨혈증을 주소로 내원하여 시행한 검사상 항이뇨호르몬 분비이상 증후군으로 진단을 받은 환자에서 일반화학 및 방사선학적 검사를 통해 비기능성 뇌하수체 종양을 진단한 예를 경험하였다. 항이뇨호르몬의 과도한 분비를 유발하는 기전은 아직 분명하지 않으나 본 증례에서와 같이 비기능성 종양에 의한 물리적 압박이 하나의 원인으로 작용할 수 있다고 생각되어 보고하는 바이다. We present a case of severe hyponatremia in a 64-year-old man who had a pituitary tumor. He had nausea and recurrent vomiting with a severe headache, and was admitted to Chungnam National University Hospital for further evaluation. On physical examination, he was alert, and had bitemporal hemianopsia. There was no indication of dehydration or edema. Laboratory data showed a serum sodium level of 126 mEq/L, plasma osmolality of 259 mOsm/kg, and urinary osmolality of 544 mOsm/kg. The plasma argipressin level was 2.88 pg/mL, despite marked hyposmolality. Otherwise, pituitary function was normal. Brain magnetic resonance imaging showed a pituitary macroadenoma measuring 25×16×13 mm and no visible normal pituitary stalk or gland in the sella turcica. After the adenomectomy, the serum sodium level maintained normal without treatment. Histology showed the presence of a pituitary adenoma. These findings indicate that a non-functioning pituitary tumor may cause the exaggerated secretion of argipressin, resulting in inappropriate antidiuretic hormone syndrome. (Korean J Med 72:315-321, 2007)