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최종상(Jong Sang Choi),장현주(Hyun Ju Jang),안재수(Jae Su An),정동진(Dong Jin Choung),윤재영(Jae Young Yoon),정민영(Min Young Chung),이태희(Tai Hee Lee) 대한내과학회 1991 대한내과학회지 Vol.40 No.4
N/A It is very important to identify the risk factors for diabetic retinopathy because diabetic retinopathy is a major problem for the diabetic patient and represents the commonest cause of acquired blindness in adults. To evaluate the risk factors for diabetic retinopathy, 325 diabetic patients underwent both polaroid fundus photography and fluorescent retinal angiography using a Canon CF-U fundus camera. Clinical characteristics and the laboratory findings of patients with proliferative retinopathy and patients with background retinopathy were compared with diabetic patients with normal retinal findings. The results were as follows: 1) Of the 325 patients, 96 patients (29.5%) had diabetic retinopathy, 90 paitents (27.7%) had background retinopathy, and 6 patients (1.8%) had proliferative retinopathy. 2) In the background diabetic retinopathy group, the duration of diabetes (5.9±4.68 years) was significantly longer than the normal retinal group (3.6±3.80 years) (p < 0.01). 3) The frequency of diabetic retinopathy increased from 22.5% in those with diabetes for less than 5 years to 50.6% in those who have had it for 5 to 10 years, and to 72.2% in those who have had it for more than 10 years (p < 0.01). 4) No significant differences were observed in sex, current age, age at diagnosis, systolic blood pressure, hematocrit, serum cholesterol hemoglobin Alc, fasting blood sugar, and obesity between the diabetics with normal retinal findings and the diabetic retinopathy group. 5) The average diastolic blood pressure of the proliferative retinopathy group (88.3±7.53mmHg) was higher than that of the normal retinal findings (79.0±10.13mmHg) (p<0.05) 6) When the results of fundus photography were compared to fluorescent retinal angiography, the sensitivity and specificity of fundus photography was 66.7% and 93.9%, respectively. 7) An analysis of the distribution of microaneurysms showed microaneurysms were found to occur most frequently in the perimacular area (44.4%), and secondly in the temporal-to-macula area (26.7%). These results suggest that fluorescent retinal angiography was more valuable in detecting early diabetic retinopathy that was missed by fundus camera. The risk factors for diabetic retinopathy were the duration of the diabetes not only in the background but also proliferative retinopathy and diastolic blood pressure in proliferative retinopathy.