당뇨병성 망막증의 위험인자에 관한 고찰

최종상(Jong Sang Choi),장현주(Hyun Ju Jang),안재수(Jae Su An),정동진(Dong Jin Choung),윤재영(Jae Young Yoon),정민영(Min Young Chung),이태희(Tai Hee Lee) 대한내과학회 1991 대한내과학회지 Vol.40 No.4

N/A It is very important to identify the risk factors for diabetic retinopathy because diabetic retinopathy is a major problem for the diabetic patient and represents the commonest cause of acquired blindness in adults. To evaluate the risk factors for diabetic retinopathy, 325 diabetic patients underwent both polaroid fundus photography and fluorescent retinal angiography using a Canon CF-U fundus camera. Clinical characteristics and the laboratory findings of patients with proliferative retinopathy and patients with background retinopathy were compared with diabetic patients with normal retinal findings. The results were as follows: 1) Of the 325 patients, 96 patients (29.5%) had diabetic retinopathy, 90 paitents (27.7%) had background retinopathy, and 6 patients (1.8%) had proliferative retinopathy. 2) In the background diabetic retinopathy group, the duration of diabetes (5.9±4.68 years) was significantly longer than the normal retinal group (3.6±3.80 years) (p < 0.01). 3) The frequency of diabetic retinopathy increased from 22.5% in those with diabetes for less than 5 years to 50.6% in those who have had it for 5 to 10 years, and to 72.2% in those who have had it for more than 10 years (p < 0.01). 4) No significant differences were observed in sex, current age, age at diagnosis, systolic blood pressure, hematocrit, serum cholesterol hemoglobin Alc, fasting blood sugar, and obesity between the diabetics with normal retinal findings and the diabetic retinopathy group. 5) The average diastolic blood pressure of the proliferative retinopathy group (88.3±7.53mmHg) was higher than that of the normal retinal findings (79.0±10.13mmHg) (p<0.05) 6) When the results of fundus photography were compared to fluorescent retinal angiography, the sensitivity and specificity of fundus photography was 66.7% and 93.9%, respectively. 7) An analysis of the distribution of microaneurysms showed microaneurysms were found to occur most frequently in the perimacular area (44.4%), and secondly in the temporal-to-macula area (26.7%). These results suggest that fluorescent retinal angiography was more valuable in detecting early diabetic retinopathy that was missed by fundus camera. The risk factors for diabetic retinopathy were the duration of the diabetes not only in the background but also proliferative retinopathy and diastolic blood pressure in proliferative retinopathy.

우리나라 의과대학의 바람직한 학제에 관한 연구

최종상(Jong Sang Choi),서덕준(Duck Joon Suh),채종일(Jong Yil Chai),오희철(Hee choul Ohrr),황익근(Ik Keun Hwang),강대영( Dae Young Kang) 한국의학교육학회 1996 Korean journal of medical education Vol.8 No.2

There is a trial to increase as four years of the premedical course to make doctors with better humanities and variable educational backgrounds and good researchers in basic medicines. We studied the trial in the present situation of the Korean in scvcral vicwpoints There will be a confusion between doctor in a origanization and there are many problems expected with two different educational system in a countury Moreover, two years of premedical course and four years of medical course are enough to a clinician, especially a primary care doctor and there will be increased costs and late age to be a doctor if premedical course are increased as four years. It is not real reason for the lack of applicants to be good researchers in basic medicines that shot premedical course and lack of non-medical educational backgrouds. Also situation of medical school in Korea is not suffice to extend their facilities and faculties. Finally advantages from the extension of the premedical course can be gained with introductions of the limeted bachelor`s admission and or dual major system. The most important things is the single educational system to be a doctor and leaving the system to the discretion of the medical schools or universities

Gravitational Stress에 대한 교감신경 부신계 반응에 관한 연구

신상구 ( Sang Goo Shin ),윤엽 ( Yup Yoon ),최종상 ( Jong Sang Choi ),박근조 ( Keun Jo Park ),박정국 ( Joung Kook Park ) 국군의무사령부 1981 대한군진의학학술지 Vol.12 No.1

알콜이 양성가속도 내성에 미치는 효과

신상구 ( Sang Goo Shin ),최종상 ( Jong Sang Choi ),황정민 ( Jung Min Hwang ),송동빈 ( Dong Bin Song ),이진학 ( Jin Hak Lee ),박정국 ( Jung Kook Park ) 국군의무사령부 1980 대한군진의학학술지 Vol.11 No.1

타액선 상피성 종양 387례에 대한 연구

채성원,최건,최종상,송재준,정광윤,최종욱,Chae, Sung-Won,Choi, Geon,Choi, Jong-Sang,Song, Jae-Jun,Jung, Kwang-Yoon,Choi, Jong-Ouck 대한기관식도과학회 1998 大韓氣管食道科學會誌 Vol.4 No.2

There have been few large scale surveys of salivary gland tumors, because the salivary gland tumors comprised less than 3 percent of all neoplasms of the head and neck. Also there is a problem that the incidences of specific types of tumors have the variation according to the geographic regions. ]'nother Korean reports about salivary gland tumor, they only treated about 100 cases only. Objectives : The purpose of this study is to identify the frequency and clinical characteristics of salivary gland tumors and to compare with other Korean reports. Materials and Methods : We had performed to analyze 387 cases of salivary gland tumors from 1983 to June 1997, were reviewed in histopathological and clinical aspects. The diagnoses of individual tumors were based on the World Health Organization classification. Tumors were analyzed according to the histologic type site, age and sex. Results : The majority (79.1%) of cases occurred in the major salivary glands and 20.9% in the minor. The parotid gland was the most frequent site with 52.4% and submandibular glands with 26.3%. Benign tumors were 79.3% of the tumors and malignant tmon were 20.7%. The most frequent tumor was pleomorphic adenoma occupied 63.8% of the total and frequency percent of histologic type of 98 malignant tumors showed 35.7% of mucoepidermoid carcinomas, 24.5% of adenoid cystic carcinomas. Overall gender with female predominance with 1 : 1.4 of male to female ratio. The average age of patients was 42.8 years. The most frequent chief complaint was a palpable mass. The duration of the symptom was shorter in the malignant salivary gland tumors (26.7 months) than in the benign salivary gland tumors (38.2 months). Conclusion : Comparing to the previous Korean reports, the present study confirms that the incidence of salivary gland tumor was lower in the parotid gland, and was higher in the submandibular and minor salivary glands.

위선암에서 Survivin과 KAI-1의 발현에 대한 연구

이주한,김병수,최종상,Lee Ju-Han,Kim Byung-Soo,Choi Jong-Sang 대한위암학회 2003 대한위암학회지 Vol.3 No.1

Purpose: The aim of this study was to investigate the impact of survivin expression and the decrease or loss of KAI-1 on the clinical stage and the survival rate in gastric adenocarcinomas. Materials and Methods: Expressions of survivin and KAI-1 were immunohistochemically determined in 40 cases of gastric adenocarcinomas. The survivin and KAI-1 expressions were also analyzed by using western blots in 14 cases among them. Results: Resected gastric cancer specimens from 40 patients (intestinal type: 15 cases and diffuse type: 25 cases) were evaluated immunohistochemically. Survivin protein expressions were significantly higher in diffuse types (P=0.03) and in advanced clinical stages (UICC TNM II and III, P=0.02). In contrast, a decrease or loss of KAI-1 expression had no statistically significant correlation with the Lauren classification or the clinical stage. Survivin protein positivity was associated with an unfavorable prognosis. Decrease or loss of KAI-1 was associated with a shorter disease free survivial rate (P < 0.01). The western blot data (n=14) indicated that neither survivin protein over-expression nor KAI-1 down-expression had an significant correlation with the Lauren classification or the clinical stage. Conclusion: In gastric carcinomas, survivin over-expression and decrease or loss of KAI-1 were associated with unfavorable prognosis, being independent prognostic factors along with the clinical stage and the disease free survival rate.

위선암에서 Heregulin과 ErbB Family 단백 발현과 임상.병리학적 예후인자와의 상관관계

류창학,이주한,최종상,Yoo, Chang-Hak,Lee, Ju-Han,Choi, Jong-Sang 대한위암학회 2006 대한위암학회지 Vol.6 No.3

Purpose: Heregulin is a natural ligand for erbB3 and erbB4. However, very little is known about their roles in the gastric cancer This retrospective study was performed to evaluate the frequencies of heregulin and erbB family protein expression and to compare their expressions with clinicopathologic parameters. Materials and Methods: Immunohistochemical expressions of heregulin and erbB family proteins were examined with tissue micro-array slides. A total of 251 gastric adenocarcinomas were classified as early cancers and advanced cancers and as having and not having lymph node metastases. Results: The positive rates of the heregulin, erbB1, erbB2, erbB3, and erbB4 protein stainings were 64%, 68%, 6%, 88%, and 76%, respectively. Intestinal type gastric adenocarcinomas showed higher expression of heregulin, erbB2, erbB3, and erbB4 proteins. Heregulin and erbB4 proteins showed lower expressions in advanced gastric carcinomas. However, erbB2 protein showed higher expression in advanced gastric carcinomas. The protein expressions of heregulin and erbB family proteins showed no relationship with survival rate. Co-expression groups of heregulin and erbB3 proteins or heregulin and erbB4 proteins showed higher expressions in intestinal type adenocarcinomas and early gastric carcinomas. Conclusion: Heregulin, erbB3, and erbB4 proteins may play a role in the early stage of adenocarcinomas. 목적: Heregulin은 erbB3와 erbB4의 리간드로 작용한다. 그러나 위암에서 이들 단백의 역할에 대해서는 거의 알려져 있지 않다. 저자들은 위암에서 heregulin과 erbB family 단백 발현 빈도를 알아보고 이들 단백 발현과 임상 병리학적 예후인자와 비교하고자 한다. 대상 및 방법: Tissue microarray와 면역조직화학염색 방법을 이용하여 heregulin과 erbB 단백 발현을 검사하였다. 251 예의 위암을 조기위암, 진행성 위암, 림프절 전이 여부 등에 따라 구분하였다. 결과: Heregulin, erbB1, erbB2, erbB3, erbB4 단백은 각각 64%, 68%, 6%, 88%, 76%로 발현되었다. Heregulin, erbB2, erbB3, erbB4 단백은 장형에서 더 높은 발현을 보였다. Heregulin과 erbB4 단백은 진행성 위암에서 발현이 낮아졌다. ErbB2 단백은 진행성 위암에서 발현이 증가되었다. Heregvlin과 erbB family 단백은 생존율과는 상관관계가 없었다. Heregulin과 erbB3 혹은 heregulin과 erbB4 단백이 동시에 발현되는 군은 장형과 초기 병변에 더 많았다. 결론: Heregulin, erbB3, erbB4 단백들은 주로 위암 초기 병변에 관여하는 것으로 추정된다.

지상 및 고공환경에서의 Harvard Step Test

황정민 ( Jung Min Hwang ),최종상 ( Jong Sang Choi ),신상구 ( Sang Goo Shin ),한광수 ( Kwang Su Han ) 국군의무사령부 1980 대한군진의학학술지 Vol.11 No.1

귀밑샘의 형질세포와 호산성 조직구를 다량 함유한 림프절외 변연부 B-세포 림프종의 세침흡인 세포검사 소견 -1예 보고-

이영석,안정석,채양석,염범우,최종상,김철환,Lee, Young-Seok,An, Jung-Suk,Chae, Yang-Seok,Yeom, Bom-Woo,Choi, Jong-Sang,Kim, Chul-Hwan 대한세포병리학회 2007 대한세포병리학회지 Vol.18 No.2

The authors present the fine needle aspiration cytology (FNAC) cytologic findings of a case of extranodal marginal zone B cell lymphoma (MZBCL), which featured abundant plasma cells and eosinophilic histiocytes arising in both parotid glands. A 49-year-old female presented with palpable masses in both parotid glands. She had been suffering from systemic lupus erythematosus and rheumatoid arthritis. The lesions were evaluated by FNAC and smears showed a small number of clusters of oncocytic cells with abundant eosinophilic granular cytoplasm and small nuclei, intermixed with small to medium-sized lymphoid cells containing round to lobulated nuclei, which suggested Warthin's tumor. Some of lymphoid cells had a plasmacytoid appearance, and some scattered large cells contained a large amount of eosinophilic cytoplasm. Bilateral superficial parotidectomy was performed and a histopathologic study indicated MZBCL with abundant plasma cells, intermixed with eosinophilic histiocytes. The presence of oncocytic cells and a mixture of lymphoid and plasma cells indicates Warthin's tumor, but the cytologic features of a relatively monotonous small to medium-sized lymphoid infiltrate suggest the possibility of MZBCL in the clinical setting of an FNAC study performed on a patient suffering from a connective tissue disease.

당뇨병성신증 조기진단법의 비교 고찰

장현주(Hyun Ju Chang),최종상(Jong Sang Choi),정동진(Dong Jin Jeong),박상선(Sang Seon Park),정민영(Min Young Chung),이태희(Tai Hee Lee) 대한내과학회 1992 대한내과학회지 Vol.43 No.1

N/A Background: As a late complication the diabetic nephropathy is a major cause of death in diabetic patient. For early detection of diabetic nephropathy, the morphologic examination by renal biopsy and the urinary excretion of microalbumin, N-acetyl-p-Dglucosaminidase (NAG), β2-microglobulin (β2-MG), transferrin, leucine aminopeptidase (LAP), kappa light chain, retinol-binding protein and β-galactosidase have been measured. Methods: The 38 NIDDM patients and 21 control subjects were studied and the diabetic patients were divided into three groups according to the results of urinalysis and Micro-Blumintest (group I: no proteinuria in random urine and microalbuminuria negative, n=19; group II: only microalbuminuria positive, n=7; group III: overt proteinuria, n=12). We measured the urinary excretion of NAG (Colorimetric method),β2-MG (EIA) and microalbumin (Micro-Bumintest), and compared with the diagnostic availability of these for early detec- tion of diabetic nephropathy among groups. Results: The urinary concentrations of NAG were 5,0±0.9U/L (mean±SE), 21,l±32,7U/L, 28,8±6.2U/L, and 2.7±0.6 U/L in group I, II, III and control, respectively and the value of group II was significantly higher than that of group I (p <0. 01) and the value of group III was significantly higher than that of group II (p <0. 001). The urinary concentrations of p-MG were 87,1±38,4 p g/L, 143.8±62.2pg/L, 1182,9±724.4pg/L, and 34.3±8,0pg/L in group I, II, III and control, respectively and significant differences among groups were not shown. Conclusion: In addition to the measurement of urinary microalbumin, the urinary excretion of NAG may be useful test for early detection of diabetic nephropathy