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흰쥐에서 척수강내로 투여한 AMPA 수용체 길항제, ACEA 2085 의 항통각과민 효과
전종헌(Jong Hun Jun),염종훈(Jong Hoon Yeom),김용철 대한통증학회 1999 The Korean Journal of Pain Vol.12 No.1
N/A Background: To study the role of spinal alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors in pain behaviors caused by mild bum, we examined the effect of intrathecal administered ACEA 2085, which has been recently characterized as a high potency competitive AMPA receptor antagonist, on the thermal hyperalgesia state induced by mild burn. Methods: A thermal injury was induced by applying the left hind paw to a thermal surface (52.5C) for 45 sec, Thermal escape latency of the hind paw was determined using an underglass thennal stimulus. Thirty min after thermal injury, the paw withdrawal latency (PWL) in injured paw of all groups fell from 10-12 sec to 5-7 sec. At that time, ACEA 2085 (0.01-0.1 mcg) and 6-cyano-7-nitroquin- oxalinedione (CNQX, 1-30 mcg) were injected through intrathecal catheters in rats with mild burn injury on the right hindpaw, And then, PWL were measured in the both hindpaw every 30 minutes for about three hours. Results: The intrathecal injection of ACEA 2085 produced a dose dependent reversal of the hyperalgesia in the right hindpaw and more potent than CNQX, but had no effect upon the response latency of the normal left hind paw even at the largest doses. All effects were observed at doses that had no significant effect upon motor function. Conclusions: Intrathecal ACEA 2085, highly selective AMPA receptor antagonist produce a dose- dependent reversal of the thermal hyperalgesia evoked mild burn injury. These results suggested that spinal AMPA receptor play an important role in the hyperalgesia induced by mild burn injury.
임상연구 : 의식 있는 중환자실 환자에서 기관 내 흡인 시 Propofol과 Fentanyl의 정맥 내 투여가 Bispectral Index에 미치는 영향
이재익 ( Jae Ik Lee ),전종헌 ( Jong Hun Jun ),김교상 ( Kyo Sang Kim ),서정국 ( Jung Kook Suh ) 대한마취과학회 2007 Korean Journal of Anesthesiology Vol.52 No.2
Background: We performed a prospective, randomized, and controlled trial to evaluate the effect of an intravenous fentanyl and propofol on the variation in BIS level associated tracheal suction. Methods: Thirty ICU patients intubated or tracheostomized were randomly allocated to control and experimental groups. Control group was received saline and experimental groups were received propofol with or without fentanyl intravenously prior to tracheal suction. And then we monitored BIS index, blood pressure, heart rate and SpO2 before, during and after tracheal suction. Results: BIS index was significantly lower in propofol plus fentanyl group than others during experiment (P < 0.05). Heart rate and blood pressure in propofol plus fentanyl group also less increased than those in control or propofol group during tracheal suction (P < 0.05). Conclusions: These results suggest that co-administration of propofol and fentanyl has more effective than propofol alone in sedation and analgesia of ICU patients during tracheal suction. (Korean J Anesthesiol 2007; 52: 156~60)
복강경하 담낭절제술을 받는 심질환 노인에서 역 Trendelenburg체위가 혈역학에 미치는 영향
김교상 ( Kyo Sang Kim ),이시민 ( Si Min Yi ),전종헌 ( Jong Hun Jun ),정미애 ( Mi Ae Cheong ),구민석 ( Min Seok Koo ) 대한마취과학회 2009 Korean Journal of Anesthesiology Vol.56 No.4
Background: We studied the hemodynamic changes induced by pneumoperitoneum and a reversed Trendelenburg in elderly patients with increased cardiac risk (ASA class III; n=30; age 70.8±4.9 years, mean±SD) and compared the results with elderly patients at normal risk (ASA class II; n=30; age 69.2±4.1 years) during laparoscopic cholecystectomy. Methods: The transesophageal Doppler monitor was performed after induction of general anesthesia (pre-incision), after onset of pneumoperitoneum (insufflation), after head-up (20°) and a left lateral tilt (15°) (reversed Trendelenburg) and after deflation and horizontal position (desufflation). Mean arterial pressure (MAP), heart rate, cardiac index (CI) and systemic vascular resistance (SVR) were measured, respectively. Results: Induction of pneumoperitoneum and head-up tilt in patients with cardiac risk resulted significantly in a decrease in CI and an increase in SVR compared with patients with normal risk (P<0.05), and that remained until deflation, but no interval changes in MAP and heart rate. The CI, MAP and heart rate decreased and SVR increased significantly in patients with cardiac risk compared with patients with normal risk before incision (P<0.05). No complications occurred. The results indicate that pneumoperitoneum and a reversed Trendelenburg are associated with significant but relatively benign hemodynamic changes. Conclusions: Anesthesia for laparoscopic cholecystectomy in elderly patients with increased cardiac risk should be performed with an adequate hemodynamic monitoring. (Korean J Anesthesiol 2009;56:398~402)