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      • KCI등재SCOPUS

        자궁경부암에서의 Telomerase 활성도

        이경아(Kyung Ah Lee),장태기(Tae Kee Jang),영진(Young Jin Jang),이영기(Young Gi Lee),이두진(Doo Jin Lee),이승호(Sung Ho Lee) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.2

        Objective: Telomerase is a ribonucleoprotein that synthesizes TTAGGG repeats onto chromosome ends. The expression of telomerase is thought to be required for cellular immortality and carcinogenesis. This study was conducted to examine the telomerase activation occurs in cervical carcinogenesis. Methods: The standard telomeric repeat amplification protocol(TRAP) was used to examine telomerase activity in tissues of 10 normal cervix, 10 carcinoma in situ, and 21 invasive cervical carcinoma. Results: Telomerase activity was detected in tissues of 16/21(76.2%) invasive carcinoma, in 5/10(50.0%) carcinoma in situ, and in 3/10(30.0%) normal cervix. But the degree of telomerase activity in normal cervix was weak. There was significant difference in 3 groups(p<0.05). The results of neoadjuvant chemotherapy in 10 invasive cervical carcinoma were as follows. In 8 cases of which tumor size decreased more than 50%, 5 were positive for telomerase. In 2 cases that didn't respond to chemotherapy by tumor size, 1 was positive for telomerase. There was no significant difference between 2 groups. All of the 5 cases that had pelvic lymph node metastasis revealed positive telomerase activity, and the 11 cases of 16 cases that didn't have pelvic lymph node metastasis were positive for telomerase, but there was no significant difference in 2 groups. The positivity of telomerase activity in clinical stage of invasive cervical carcinoma was 73.3% in stage I(11/15), 75.0% in stage II(3/4), 100% in stage III(1/1), and 100% in stage IV(1/1), but there was no significant difference in each stages. Conclusion: Telomerase seems to be uniquely associated with malignant transformation of cervix and can be used as a tumor marker. Additional studies are needed to better clarify the biological significance of telomerase expression in cervical tumorigenesis.

      • KCI등재

        태아 손의 선천성 절단이 동반된 양막외임신

        박동수 ( Dong Su Park ),정용욱 ( Yong Wook Jung ),이지은 ( Jee Eun Lee ),김영주 ( Yonng Joo Kim ),장태기 ( Tae Kee Jang ),강승룡 ( Seung Ryong Kang ),이건호 ( Gun Ho Lee ) 대한주산의학회 2012 Perinatology Vol.23 No.1

        Extra-amniotic pregnancy, which is caused by rupture of amniotic membranes only, is a rare event during pregnancy. This differs from extra-membranous pregnancy in which both chorionic and amniotic membranes rupture. Extra-amniotic pregnancy requires attention by an obstetrician not to miss fetal anomalies because extra-amniotic pregnancy may accompany with fibrous band syndrome. We experienced a case of extraamniotic pregnancy with congenital amputation of bilateral fetal hands. And we report it with brief review of literatures.

      • KCI등재

        자궁내 사망한 무뇌증을 동반한 쌍태 임신 1예

        김수진 ( Su Jin Kim ),백종우 ( Jong Woo Baek ),박영세 ( Young Se Park ),공두식 ( Du Sik Gong ),이건호 ( Geun Ho Lee ),장태기 ( Tae Kee Jang ),강승룡 ( Syung Ryoung Kang ),백영일 ( Young Ihl Baek ),한세열 ( Se Yul Han ) 대한주산의학회 2006 大韓周産醫學會雜誌 Vol.17 No.3

        최근 불임 치료 기술이 발달되면서 쌍태 임신의 빈도는 점차 증가하는 추세이다. 그러나 쌍태 임신에서 기형아가 단태 임신에서 보다 높은 빈도로 발생하고 특히 일측 태아에서 기형이 동반한 쌍태 임신의 경우, 적절한 치료 및 상담에 상당한 어려움이 있다. 본원 산부인과에서는 무뇌아를 동반한 쌍태 임신 산모에게 유전 상담을 통해 정상아의 폐성숙이 완성될 때까지 임신을 유지하기로 하여 임신 35주 6일까지 경과 관찰하던 중 무뇌아가 자궁내 사망하여 비정상 태위로 제왕절개를 통해 2,160 g의 정상아와 600 g의 측만증과 좌측 상지 부재를 동반한 무뇌아를 성공적으로 분만한 1예를 경험하였기에 간단한 문헌 고찰과 함께 보고하는 바이다. Twin Pregnancies are increasing these days due to recent development of the technology in treating infertility. twin pregnancies tend to cause more congenital anomalies than singleton pregnancies do. Especially when twin pregnancies are affected with one anomalous fetus combined to a normal one, the proper management and counseling are difficult. We experienced a twin pregnancy in which one anencephalic fetus was combined to a normal one, after close counseling we decided to continue the pregnancy. At 35 weeks 6 days of gestation, an anencephalic fetus was dead, so we delivered by cesarean section due to breech-cephalic presentation. The birth weight of the normal and anencephalic fetuses were 2160 gm and 600 gm, respectively. The anencephalic fetus was combined with scoliosis, absent left upper limb, and nuchal skin defect, but the healthy one showed good crying and movement and its Apgar score was 8 in 1 minute and 9 in 5 minute. Although the infant needed intensive care for 21days in the nursery room, she was finally discharged in good condition. We present this case with a brief review of the literature.

      • Delayed Resolution of Cervical Lesion of Ectopic Pregnancy Treated by Intra-amnionic Methotrexate (MTX) Instillation: A Case Report

        Lee,Tae Hyung,Lee,Kang Hyok,Jang,Tae Kee,Koh,Min Whan,Han,Kuk Sun 영남대학교 의과대학 1999 Yeungnam University Journal of Medicine Vol.16 No.1

        자궁경관 임신은 최근에 인공유산의 증가와 인공 보조 생식술(assisted reproductive technology) 등에 의하여 증가되는 양상을 보인다. 과거에는 자궁경관 임신은 대량의 무통성 질출혈로 진단을 내리고 치료 방법은 전자궁적출술이 유일한 수단이었으나, 지금은 질식 초음파의 개발로 자궁경관 임신을 조기에 진단하고 자궁 보존적 방법으로 치료하여 차후 임신을 기대할 수 있게 되었다. 그 치료 방법 중 하나로 Methotrexate(MTX)를 주사하여 성공적으로 치유된 많은 보고들이 있었다. 본 저자들은 임신 8주에 자궁경관 임신으로 진단된 환자에서 전신적 MTX 투여와 복식 초음파 관찰 하에 양막강내 MTX 투여 병합 요법으로 치료한 1 례를 보고하고 치료과정에서 자궁경부 병변의 지연 관해에 대해서 문헌 고찰과 함께 보고하는 바이다.

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