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결장직장암에서 Nuclear Factor-κB p65와 Nuclear Factor-κB p50 단백 발현과 임상병리학 인자와의 연관성
강기창(Gi Chang Kang),김범규(Beom Gyu Kim),박준석(Jun Suk Park),최유신(Yu Sin Choi),차성재(Sung Jae Cha),박성준(Sung Jun Park),장인택(In Taik Chang),박성일(Sung il Park),이태진(Tae Jin Lee),최영철(Young Cheol Choi) 대한외과학회 2008 Annals of Surgical Treatment and Research(ASRT) Vol.75 No.2
Purpose: Nuclear Factor-κB p65 (NF-κB p65) and nuclear Factor-κB1 p50 (NF-κB p65) have been shown to play roles in cell proliferation, apoptosis, cytokine production and oncogenesis. This study was designed to investigate the expressions of NF-κB p65 and NF-κB p50 proteins in premalignant lesions and colorectal adenocarcinoma. Methods: Paraffin sections of 20 normal mucosa specimens, 20 low grade tubular adenoma specimens, 20 high grade tubular adenoma specimens and 64 adenocarcinoma specimens were analyzed immunohistochemically for the expressions of NF-κB p65 and NF-κB p50 proteins. Results: The expressions of NF-κB p65 and NF-κB p50 proteins were significantly higher in the adenocarcinoma tissue compared with that in the normal mucosa, the low grade tubular adenoma and the high grade tubular adenoma tissues. The frequency of a NF-κB p50 expression was higher in the poorly differentiated histologic grade specimens, in the presence of nodal metastasis and in the high stage specimens. There were significant correlations between the NF-κB p65 and NF-κB p50 proteins. Conclusion: The expressions of NF-κB p65 and NF-κB p50 proteins may play a role in the pathogenesis of colorectal carcinoma.
유방암에서 Claudin-1과 ZO-1 단백 발현 감소와 임상-병리학적 인자와의 연관성
김민준(Min Joon Kim),차성재(Seong Jae Cha),박성일(Sung Il Park),박성준(Sung Jun Park),장인택(In Taik Chang),김범규(Beom Gyu Kim),최유신(Yoo Shin Choi),이태진(Tae Jin Lee) 대한외과학회 2007 Annals of Surgical Treatment and Research(ASRT) Vol.72 No.6
Purpose: Tight junction proteins are either over-expressed or suppressed in some cancers. These suppressions of claudin-1 and ZO-1 protein are known to have a significant relationship with the progression of breast cancer. The authors reviewed 42 cases of breast cancer and the staining status of claudin-1 and ZO-1 in order to evaluate Claudin-1 and ZO-1 as clinicopathologic risk factors. Methods: Immunohistological staining for Claudin-1 and ZO-1 was performed in 42 post-operative pathologically diagnosed infiltrating duct carcinoma specimens. The rate of expression was compared with the clinical record, the pathological diagnosis, the estrogen receptor and progesteron receptor status and the c-erbB2 gene to evaluate the protein expression-breast cancer progression relationship and to investigate the expressions of Claudin-1 and ZO-1 as a prognostic factors in breast cancer. Results: The claudin-1 and ZO-1 expressions were both decreased in all the post-operative specimens. The claudin-1 expressions were significantly decreased 100%, 82.4% and 66.7% as the histologic grade increased. The ZO-1 expressions were shown in 44.8% of the lymph node metastasis negative group and in 7.7% of the lymph node positive group. The expression of ZO-1 decreased by 53.3%, 28.6% and 0%, with statistical significance, as the stage increased. Conclusion: The claudin-1 expressions were decreased in the poorly differentiated group, i.e., a high histologic grade, and the ZO-1 expressions were decreased in the lymph node positive group and in the high stage cancer. This shows the possibility of Claudin-1 and ZO-1 as factors for tumorigenesis and progression and as prognostic factors in breast cancer.
김상준(Sang Jhoon Kim),신준호(Juhn Ho Shin),장인택(In Taik Chang) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.5
N/A Residual stones after biliary tract surgery were a formidable task for surgeons. So several nonoperative procedures have developed for the management of this problem. Among these procedures. extraction of residual stones using Dormia Basket was increased more and more because of the low morbidity and high success rates. This report is an analysis of 60 patients who underwent residual stone extraction using Dormia Basket from February 1989 through August 1992. There were 23 men and 37 female, whose age ranged from 29 to 74 years. The incidence was 12 cases at the 6th decade, 9 cases at the 5th decade in order of frequency. The most common symptom was RUQ pain (96.7%). Stone extraction using Dormia Basket was performed 110 time. Mean interval between the operation and the stone extraction was 51.8 days. Thc mean interval between each procedure was 11.7 days. Biliary stenosis was detected in 33 patients and dilatation was detected in 51 patients. Success rates of stone extraction was 83.3% The major causes of faiIure were impacted stones in 14 cases, ductal stenosis in 14 cases and large stone in 5 cases and the complications were RUQ pain in 16 cases and diarrhea in 14 cases but they improved progressively.
복강경 담낭 절제술 2,523예 시행 중 개복술로 전환한 111예에 대한 임상적 고찰
방지성(Ji Sung Bang),최유신(Yu Sin Choi),김범규(Beom Gyu Kim),차성재(Sung Jae Cha),지경천(Kyung Choun Chi),이정효(Jung Hyo Lee),장인택(In Taik Chang) 한국간담췌외과학회 2008 한국간담췌외과학회지 Vol.12 No.3
Purpose: While laparoscopic cholecystectomy can be successfully performed in the majority of patients, conversion to open procedure is still necessary in certain cases. The purpose of this study was to identify the discerning factors that helped to predict the need for conversion to open cholecystectomy. Methods: A retrospective review was conducted on the data for 2,523 laparoscopic cholecystectomies performed at Chung-Ang University Hospital between January 2002 and July 2007. Patient sex, age, height, weight, body mass index (BMI), duration of preoperative hospital stay, preoperative physical examination, laboratory data, radiologic findings, and reasons for conversion to open procedure were evaluated. Results: Adhesion was perceived to be the most critical factor for conversion in 56 of 111 total cases (50.5%). Bleeding (22.5%), bile duct injury (11.7%), inflammation (9.0%), and uncertain anatomy (6.3%) followed sequentially in incidence. Factors found to significantly increase the risk of conversion on univariate analysis were patient age >70 years, male sex, previous abdominal operation, preoperative common bile duct stone, tenderness in the right upper quadrant, distended shape of the gallbladder, and pericholecystic fluid collection. On multivariate analysis, the following factors were found to be associated with a higher risk: patient age >70 years (p=0.002), male sex (p=0.012), previous abdominal operation (p<0.0001), and preoperative common bile duct stone (p=0.041). Conclusion: In the case of operations with such discerning factors, surgeons should be more cautious and delicate in all procedures throughout the operative period. Furthermore, to reduce the risk of additional severe complications, surgeons need to decide early on if they will perform a conversion.
송형준(Hyung Jun Song),김종원(Jong Won Kim),박준석(Jun Seok Park),김용석(Yong Seok Kim),최유신(Yoo Shin Choi),김범규(Beom Gyu Kim),차성재(Sung Jae Cha),박성준(Sung Jun Park),장인택(In Taik Chang),박성일(Sung Il Park),박언섭(Eon Sub P 대한외과학회 2009 Annals of Surgical Treatment and Research(ASRT) Vol.77 No.1
Purpose: Postsurgical adhesion formation is a significant clinical problem within every surgical specialty. Several adhesion barriers have been developed in the form of solution, membrane or film in an attempt to solve these problems. The purpose of the present study is to compare the efficacy of antiadhesive agents in the prevention of postsurgical adhesion formation in a standardized rat adhesion model. Methods: We examined forty Sprague-Dawley rats, which is a cecal abrasion with partial peritonectomy model. Three treatment groups (Group Ⅰ: Film-type Surgiwrap<SUP>ⓡ</SUP>, Group Ⅱ: Solution-type Guardix-sol<SUP>ⓡ</SUP>, Group Ⅲ: Membrane-type Interceed<SUP>ⓡ</SUP>), each consists of 10 rats, and a control group of 10 rats were used by saline. Ten days after surgery, the rats were killed, and the levels of adhesion were graded. Immunohistochemical staining for microvessel density (CD34, MVD) and macrophage (ED1) were performed in adhesion tissue. Results: The peritoneum adhesion mean scores are as follows: control group: 2.2±0.78, Group Ⅰ: 1.0±1.06, Group Ⅱ: 0.9±0.99, Group Ⅲ: 0.6±0.84. All treatment groups showed significantly less peritoneum adhesion (P=0.006), while there was no significant difference in each group. The intraperitoneal organs adhesion mean scores are as follows: control group: 2.8±0.91, Group I: 2.6±1.06, Group Ⅱ: 1.4±0.84, Group Ⅲ: 1.0±0.81. Group Ⅰ had no significant difference about intraperitoneal organs adhesion with control group, but Group Ⅱ and Group Ⅲ showed less intraperitoneal organs adhesion. The mean numbers of microvessel density are as follows: control group: 42.5±4.83, Group Ⅰ: 40.8±6.53, Group Ⅱ: 30.9±6.15, Group Ⅲ: 15.60±4.37, from which there was a significant difference between Group Ⅱ and Group Ⅲ with control group (P<0.001). The mean numbers of macrophage are as follows: control group: 223.3±33.12, Group I: 211.25±10.96, Group Ⅱ: 171.60±23.96, Group Ⅲ: 147.0±12.22, from which there was a significant difference between Group Ⅱ and Group Ⅲ with control group (P<0.001). Conclusion: In our animal model, three different types of antiadhesive agents (Surgiwrap<SUP>ⓡ</SUP>, Guardix-sol<SUP>ⓡ</SUP>, Interceed<SUP>ⓡ</SUP>) were effective in adhesion prevention, but Surgiwrap<SUP>ⓡ</SUP> had less antiadhesive effect for intraperitoneal organs adhesion. Membrane-type Interceed<SUP>ⓡ</SUP> had a better effect for microvessel density (MVD) and macrophage than solution-type Guardix-sol<SUP>ⓡ</SUP>.
복강경 담낭 절제술을 시행 받는 환자에서 경피 경간 담도 배액관을 통한 간내외 담도 결석 제거술의 의의
선영(Young Sun),박준석(Jun Seok Park),김용석(Yong Seok Kim),최유신(Yoo Shin Choi),김범규(Beom Gyu Kim),차성재(Seong Jae Cha),장인택(In Taik Chang) 대한외과학회 2008 Annals of Surgical Treatment and Research(ASRT) Vol.75 No.6
Purpose: One of the popular and widespread treatments for intra- & extra-hepatic duct (IEHD) stone associated gallbladder (GB) stone is laparoscopic cholecystectomy (LC) with stone removal through endoscopic retrograde cholangiopancreatography (below ERCP). Because LC with stone removal through percutaneous transhepatic biliary drainage (below PTBD) is well known for its safety and feasibility in removing IEHD stones, we did this study to see the significance (safety, feasibility, effectiveness etc) of PTBD and stone removal. Methods: We compared the odds by collecting 71 retrospective cases, victims of IEHD stone associated GB stone from January, 2004 to December, 2007 in Chung-Ang University Hospital. Comparative analysis took place in 51 cases who underwent PTBD and 20 cases treated with ERCP. We excluded 6 patients who underwent PTBD for intra hepatic duct stone. Age, sex, American Society of Anesthesiologists score, pain, nausea, pre- and postlaboratory value, symptoms, size, location and number of stones, diameter of extra hepatic duct, recurrence and clearance rate, frequency of each procedure, complications, cost were investigated in this study. Results: There were no statistical differences in each group in recurrence and clearance rate or frequency of procedure. However post-procedure pancreatitis and amylase level were significantly difference in each group. PTBD group experienced much longer hospital stay but was not significantly different. Although procedure cost is three times more expensive than that of PTBD group, there were no differences in total cost and patients’ expenses between the two groups. Conclusion: PTBD would be an alternative solution in managing IEHD stone associated with GB stone for its lower rate of complication, higher clearance with minimal discomfort.