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토끼에서 신델라 겔 ( 송아지의 제단백혈액추출물 황산 미크로노아이신 = 20 1 혼합물 ) 의 피부자극성시험
남석우(Suk Woo Nam),이영진(Young Jin Lee),고영권(Young Kwon Ko),장만식(Man Sik Chang),최완수(Wahn Soo Choi),김규봉(Kyu Bong Kim),우태욱(Tae Wook Woo),한정환(Jeung Whan Han),홍성렬(Sung Youl Hong),이향우(Hyang Woo Lee) 한국응용약물학회 1996 Biomolecules & Therapeutics(구 응용약물학회지) Vol.4 No.4
This study was conducted to investigate the skin irritation toxicity of Syndella gel, a combination topical drug containing a deproteinised dialysate of calfs blood and micronomicin sulfate in the ratio of 20 to 1, in New Zealand White rabbits. In the primary skin irritation test with male New Zealand White rabbits, there was no treatment-related effect on clinical sign, and body weight was not significantly changed. The Primary Irritation Index (PII) was 0.33, indicating that Syndella gel was a mildly irritating formulation.
흰쥐에서 신델라 겔 (송아지 제단백혈액추출물 : 황산미크로노마이신=20:1 복합제제)의 30일간 반복투여 경피독성시험
남석우(Suk Woo Nam),성대석(Dae Suk Sung),유세근(Se Keun Yoo),장만식(Man Sik Chang),최완수(Wahn Soo Choi),정영국(Young Kuk Chung),김규봉(Kyu Bong Kim),한정환(Jeung Whan Han),홍성렬(Sung Youl Hong),이향우(Hyang Woo Lee) 대한약학회 1997 약학회지 Vol.41 No.2
This study was conducted to investigate the subacute transdermal toxicity of Syndella gel, a new topical drug containing deproteinized dialysate of calf''s blood and micronomicin sulfate in Sprague-Dawley rats. Three doses (1.97, 3.94, 7.88 g/kg) of Syndella gel was daily treated transdermally to male and female rats for 30 days. No death was occurred in either control or treated rats. No significant toxic clinical signs and body weight change were not observed at any doses in the male or female rats treated. There were no significant alterations in hematologic and biochemical parameters in both sexes, however slight increase of potassium concentration was observed in 3.94g/kg and 7.88 g/kg female groups. No significant necrotic changes were not observed in examined organs. This study showed that up to 7.88g/kg Syndella gel did not induce subacute transdermal toxicity.
치환 피리딘의 치환기 효과에 대한 Ab initio 연구
이갑용,장만식,Lee, Gab Yong,Chang, Mahn Sik 대한화학회 1999 대한화학회지 Vol.43 No.4
파라-치환 피리딘의 치환기 효과를 조사하기 위하여 Ab initio 계산을 수행하였다. 여러 치환 피리딘의 최적화 된 구조로부터 정전기전위를 계산한 결과 피리딘의 질소 원자에서 최소값을 나타내었으며, 최소정전기전위 값은 Hammett 치환기 상수, ${\sigma}_p$ 및 ${\Delta}pKa$와 홀륭한 상관성이 있음을 알았다. 그 결과 최소정전기전위가 치환기 효과를 나타내는 척도로 사용될 수 있음을 알 수 있었다. Ab initio calculation is performed to estimate the substituent effects for Para-substituted pyridines. Electrostatic potentials are obtained from ab initio molecular orbital wavefunctions of optimized structures for substituted pyridines. Electrostatic potentials are computed to be minimum at nitrogen atom of pyridines. The potential minima are good correlated with the substituent constants, ${\sigma}_p$ and with the ${\Delta}pKa$. It is shown that the electrostatic potential minima can be used as a measure of substituent effects.
치환 옥사졸의 양성자 친화도에 대한 ab initio 연구
이현미,이송은,장만식,박병각,이갑용,Lee, Hyun-Mee,Lee, Song-Eun,Chang, Mahn-Sik,Park, Byung-Kak,Lee, Gab-Yong 대한화학회 1995 대한화학회지 Vol.39 No.7
옥사졸 고리를 포함하는 lexitropsin에서, DNA minor groove의 염기쌍(G-C sequence)과 결합하는 부분인 옥사졸의 최적화된 기하학적 구조를 MM+ 및 ab initio(Hartree-Fock) 계산을 통해 밝혔다. 최적화딘 구조에 대해 6-31G 및 $6-31G^{\ast}$ basis set를 사용하여 양성자 친화도와 전자적 구조를 계산하였다. 아울러 옥사졸의 양성자 친화도에 미치는 치환기 효과를 알아보기 위해 전자를 주는 기와 전자를 끄는 기를 갖는 여러 치환 옥사졸에 대해 양성자 친화도를 조사하였다. 그 결과 전자를 주는 기는 옥사졸의 양성자 친화도를 증가시키는 반면 전자를 끄는 기는 양성자 친화도를 감소시킴을 알았으며, 이 결과를 치환 옥사졸의 산소의 atomic charge와 전자밀도로 설명할 수 있었다. The geometry optimization of oxazole, relevant to the binding of lexitropsin that contains this ring to the base pair (G-C sequence) of minor groove of DNA, is performed with the aid of MM+ and ab initio (Hartree-Fock) calculations. The proton affinity and electronic structure are calculated at the 6-31G and $6-31G^{\ast}$ level for the optimized geometry. The proton affinities are also studied for various substituted oxazoles with the electron-donating and -withdrawing groups to estimate the substituent effect on the proton affinities of oxazoles. It is shown that the electron-donating substituents increase the proton affinity of oxazole, while the electron-withdrawing substituents decrease it. This result can be explained with atomic charge and electron density at oxygen of substituted oxazoles.
랫트에 있어서 신델라 겔 ( 송아지의 제단백혈액추출물 황산 미크로노마이신 = 20 1 혼합물 ) 의 피하급성독성시험
남석우(Suk Woo Nam),서동완(Dong Wan Seo),안성훈(Sung Hoon Ahn),장만식(Man Sik Chang),최완수(Wahn Soo Choi),김규봉(Kyu Bong Kim),우태욱(Tae Wook Woo),한정환(Jeung Whan Han),홍성렬(Sung Youl Hong),이향우(Hyang Woo Lee) 한국응용약물학회 1996 Biomolecules & Therapeutics(구 응용약물학회지) Vol.4 No.4
Single subcutaneous administration to S.D rats of both sexes was performed to investigate the acute toxicity of Syndella gel, a new topical drug containing deproteinised dialysate of calfs blood and micronomicin sulfate. LD_(50) values for S.D rats were 23,047 ㎎/㎏ for male and 23,725 ㎎/㎏ for female. The death occurred within 24 hours after administration at doses over 19,200 ㎎/㎏. The main cause of death seemed to be respiratory disturbance by acute shock. Major general symptoms induced by injection subcutaneously with Syndella gel were underactivity, decreased respiratory rate, salivation, tremor and loss of consciousness. No significant body weight changes and gross findings of internal organs in treatment groups in comparison with those of control groups was observed at any dose levels in Syndella gel.
장만식 효성여자대학교 새마을연구소 1984 새마을硏究論文集 Vol.4 No.-
The commercial law was revised on the April 10th in 1984 on the 22th years. A lot of sections of the revised commercial law are Connected with emterprises accounting. The objectives of commercial law are the protection of creditors and those of enterprises accounting provide the usefullness accounting information to the users, however, those are connected with each other of the maintenance and growth of enterprises, and the realization of social justice. This study has analyzed and summarized the effects of each other related with commercial law and accounting standards(GAAP). Main contents are as follows; (1) Commercial law influenced by accounting standard(GAAP). 1) revision of the items in the trade book. 2) treatment method of the trade book and preference of accounting procedures. 3) unification of the assets valuation. 4) revision of the items in financial statements. 5) concrete enters of the items in operating report. 6) recognition of the board of directors and extention of the disclousure period about financial statements. 7) entry methods and form of financial statements. 8) date of presentation and period of auditing about financial statements. (2) Accounting standard(GAAP) influenced by commecial law. 1) adjustment of the extent of the capital surplus reserve. 2) change of the reserve standards in the retained earnings-legal reserve. 3) adjustment of the items in the statement of treatment of deflicit. 4) establishment of the accounting procedure of stock dividents. 5) establishment of the accounting procedure of stock subecription warrants(or, bonds with stock purchase warrants) 6) adjustment of the supplementary footnots. (3) Other problems. 1) addition of the statement of changes in finacial position in financial statements of the commercial law. 2) addition of the start-up costs, research and development costs, and foreign exchanges loses in the deferred assets of the commercial law. 3) adjustment of the content in consolidated company of the accounting standards. 4) provisions of the items of other capital surplus in the commercial law.
商法上의 計算規程에 나타난 會計制度 發達過程에 관한 硏究(Ⅱ)
張晩植 효성여자대학교 산업경영연구소 1997 경영경제 Vol.14 No.-
Generaly accepted accounting standards (GAAP) influenced by commercial law. The objectives of commercial law are the protection of creditors and those of enterprises accounting provide the usefullness accounting information to the users, however, those are connected with each other of the maintenance and growth of enterprises, and the realization of social justice. This study has analyzed and summarized the accounting system of the commercial law in 1962. Main contents are as follows ; 1) accounting documentarys are list of properties, balance sheet, operrating report, income statement, statements of appropriations of retained earnings. 2) disclosure of the auditor's opinion 3) disclosure of the balance sheet 4) current assets valuation : cost basis and lower basis of cost or market price 5) fixed assets valuation : cost basis and depreciation 6) bonds valuation : current basis 7) stocks valuation : current basis 8) goodwill valuation : cost basis 9) defferd charge are organization costs pre-operating costs, new stock issuance costs, research and development costs 10) reserve are legal reserve, free reserve and secret reserve 11) capital surplus : paid-in capital in excess of par value, gain on business combination and other capital surplus 12) regulation of the dividend 13) examination of the stockholder's