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화병 핵심증상 중 흉민에 대한 분심기음의 효능: 무작위배정, 이중맹검, 위약대조군연구의 중간보고 -피험자 특성을 중심으로
임현주 ( Hyeon Ju Yim ),김석환 ( Seok Hwan Kim ),이상룡 ( Sang Ryong Lee ),강위창 ( Wee Chang Kang ),정인철 ( In Chul Jung ) 대한한방신경정신과학회 2009 동의신경정신과학회지 Vol.20 No.3
Objectives: The purpose of this research is to examine the effect of Bunsimgi-eum on the chest discomfort of Hwa-byung`s major symptom. Methods: In this randomized, double blinded, placebo-controlled study, we planned to give Bunsimgi-eum or controlled medication for major symptoms of Hwa-byung. As preparatory research, 100 mm Visual Analogue Scale(VAS) for chest discomfort, the Hwa-byung` major symptom was measured as the 1st evaluative instrument, and Likert scale for major symptom of Hwa-byung, Korean State-Trait Anger Expression Inventory(STAXI-K), Korean State-Trait Anxiety Inventory (STAI-K), Korean Beck`s Depression Inventory(BDI-K) and Heart Rate Variability(HRV) were also measured as the 2nd evaluative instrument at the before treatment. Results: Clinical characteristics-vital signs & demographic characteristics showed no significant difference between both groups. The characteristics of disease-chief complaint, pattern Identification, period, etiological factor, etc, also showed no significant difference between both groups. There were almost no Coincidence between pattern identification & weight of Hwa-byung`s major symptoms. The results of Chest PA, EKG and clinicopathologic examination showed no significant difference between both groups. There were no significant difference between both groups in all valuation scales; 100 mm Visual Analogue Scale for chest discomfort, the Hwa-byung` major symptom was measured as the 1st evaluative instrument, and Likert scale for major symptom of Hwa-byung, STAXI-K, STAI-K, BDI-K and HRV. Conclusions: We considered that establishment of experimental group and controlled group was objective and worth conducting this research. And this methodology is expected to be applied to the subsequent research. And also, we hope to make up for this study through various study and discussion.
가감신기환(加減腎氣丸) 제형변화가 염증반응 사이토카인과 기억력감퇴에 미치는 영향
임현주 ( Hyeon Ju Yim ),정인철 ( In Chul Jung ) 대한한방신경정신과학회 2008 동의신경정신과학회지 Vol.19 No.3
Objective : This experiment was designed to investigate the effect of the KSKH hot water extract & ultra-fine powder on microglia and memory deficit model Method : The effects of the KSKH hot water extract on expression of IL-1β, IL-6, TNF-α mRNA and production of IL-1β, IL-6, TNF-α in BV2 microglial cell line treated by lipopolysacchaide(LPS) were investigated. The effects of the KSKH hot water extract & ultra-fine-fine powder on the behavior of the memory deficit mice induced by scopolamine and AChE in serum of the memory deficit mice induced by scopolamine were investigated. Results : 1. The KSKH hot water extract suppressed the expression of IL-1β, IL-6, TNF-α mRNA in BV2 microglial cell line treated by LPS. 2. The KSKH hot water extract suppressed the production of IL-1β, IL-6, TNF-α in 100㎍/ ㎖ concentration of BV2 microglial cell line culture supernatant. 3. The KSKH hot water extract & ultra-fine powder decreased AChE activation significantly in the serum of the memory deficit mice induced by scopolamine. 4. The KSKH hot water extract & ultra-fine powder showed significant effect on memory impairment in the stop-through latency type of Morris water maze test. Conclusions : This experiment shows that the KSKH hot water extract & ultra-fine powder might be effective for the prevention and treatment of amnesia and Alzheimer`s disease. Investigation into the clinical use of the KSKH hot water extract & ultra-fine powder for amnesia and Alzheimer`s disease is suggested for future research.