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고콜레스테롤 조건하에 배양된 HepG2에서의 ginsenoside-Rb₂에 의한 LDL receptor 억제 완화 기전
임그리워(G-Rewo Lim),이현일(Hyun-Il Lee),김은주(Eun-Ju Kim),노영태(Young-Tae Ro),노연희(Yun-Hee Noh),구자현(Ja-Hyun Koo) 고려인삼학회 2004 Journal of Ginseng Research Vol.28 No.2
The effect of ginsenoside-Rb2, one of a major pharmacological component of Panax ginseng c.A. Meyer. on low density lipoprotein (LDL) receptor expression was investigated and compared with hypocholesterolemic dl1lg lovastatin. In HepG2 cell. exogenous cholesterol decreased LDL receptor mRNA expression, but ginsenoside-Rb2 recovered this reduction of LDL receptor mRNA up to normal expression level. Lovastatin also increased LDL receptor mRNA expression as similar as ginsenoside-Rb2 did. The reduction of sterol regulatory element binding protein (SREBP) transcription by exogenous cholesterol was also similarly recovered by ginsenoside-Rb2 and lovastatin addition. Compound K, a metabolite of ginsenoside-Rb2 and -Rb I by human intestinal bacteria also increased the SREBP mRNA expression in cholesterol-enriched condition. Ginsenoside-Rb2 seems to up-regulate LDL receptor mRNA expression through the induction of de 1101'0 SREBP transcription. Therefore. increased expression of SREBP mRNA by ginsenoside-Rb2 elevated the LDL receptor mRNA expression in HepG2 cells. and these inductions possibly drop the plasma cholesterol level in hypercholesterolemia patients. ill vivo, as likely in case of lovastatin.
노연희,임그리워,구자현,Noh, Yun-Hee,Lim, G-Rewo,Koo, Ja-Hyun 고려인삼학회 1996 Journal of Ginseng Research Vol.20 No.3
The effects of ginseng total saponin, ginsenoside-Rb, and -Rb, on the reduction of chmlesterol level and the myNA expression rates of HMG CoA reductase and LDL receptor in Hep G2 were investigated and compared with that of lovastatin, a competitive HMG CoA reductase Inhibitor. The amounts of cholesterol in Hep G2 decreased in total saponin-and ginsenoside-treated groups as compared with that of control group, while there was no significant reduction in lovastatin-treated group. The mRNA expression rates of HMG CoA reductase increased in total saponin and gin- senoside groups except for ginsenoside-Rb, (10-3%) group and decreased in lovastatin group com- pared with that of control group. The mRNA expression rates of LDL receptor generally increased In all of the test groups except for total saponin (10-5%) group compared with that of control group. Because the ginseng components tested were more effective in the reduction of cholesterol level in Hep G2 than lovastatin and induced the gene expression of LDL receptor, we suggest the possibility that they could be used as a replacement agent for lovastatin which can not be prescribed especially to patients with hepatic diseases.