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RISS 인기검색어
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- 저자 : 이혁표(Hyeok Pyo Lee) (검색결과 2 건)
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김선영 ( Sun Young Kim ),박종혁 ( Jong Hyeok Park ),이현경 ( Hyun Kyung Lee ),이혁표 ( Hyuk Pyo Lee ),이혜경 ( Hye Kyung Lee ),최수전 ( Soo Jeon Choi ),염호기 ( Ho Kee Yum ) 대한결핵 및 호흡기학회 2007 Tuberculosis and Respiratory Diseases Vol.63 No.4
폐경기 여성에서 호르몬 대체요법은 폐경기 증상의 경감, 골다공증에 의한 골절, 대장암의 위험도 감소 등의 효과가 인정되어 왔다. 현재도 많은 폐경기 여성에게 사용되어지고 있는 치료법이다. 그러나 그에 따른 부작용 또한 점차 밝혀지며 연구 되고 있다. 이러한 부작용 중 생명을 위협 할 수 있는 폐색전증은 호르몬요법을 사용할시 항상 각별한 주의를 요한다. 폐경기 호르몬대체요법이 필요할 경우 심부정맥혈전증과 폐색전증의 다른 위험인자나 환경적 요인 등을 가진 환자에게 그 사용에 있어 더욱 주위를 기울여야 한다. 또한 폐색전증의 가장 많은 증상인 호흡기 증상이 있을 경우 즉시 적절한 평가와 치료가 필요하다. Hormonal replacement therapy (HRT) has been proven for treatment of postmenopausal symptoms such as hot flushes, night sweats and urologic symptoms. HRT became very popular in the 1990`s, when there were several reports showing that it also helped with other menopausal complications such as osteoporosis and cardiovascular disease. Recent studies report that the incidence of breast cancer, endometrial cancer, cerebral infarction, coronary artery diseases, deep vein thrombosis and pulmonary thrombembolism could rise after HRT. Among these side effects of HRT, the risk of pulmonary thromboembolism increases 2 to 4 fold after HRT, but can vary with the use of different doses and preparations. Here, we summarize the risk factors and clinical courses for 5 patients who developed pulmonary thromboembolism after postmenopausal HRT. (Tuberc Respir Dis 2007; 63: 362-366)
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김호중(Ho Joong Kim),최형석(Hyung Suk Choi),심태선(Tae Sun Shim),이혁표(Hyeok Pyo Lee),김영환(Young Whan Kim),허대석(Dae Seog Heo),한성구(Sung Koo Han),심영수(Young Soo Shim),김노경(Noe Kyeong Kim),김건열(Keun Youl Kim),한용철(Yong C 대한내과학회 1991 대한내과학회지 Vol.41 No.2
Pulmonary toxicity is a potentially fatal complication of bleomycin, one of the well-known anti-cancer chemotherapeutics. The incidence of bleomyicn-induced pulmonary toxicity was reported as 2-40% and fatality, 1-2%. Bleomycin-induced pulmonary toxicity is sometimes progressive even after discontinuation of the drug, but there has been no specific treatment modalities other than prevention, Forced vital capacity (FVC) and carbon monoxide diffusing capacity (DLco) have been proposed as parameters valuable in predicting subclinical bleomycin-induced pulmonary toxicity, but there are still conflicting results. To discover the predicting factors for bleomycin-induced pulmonary toxicity, 15 patients treated with 6 cycles of cyclophophamide, vinblastine, prednisolone, bleomycin, adriamycin and procarbazine (COPBLAM- III) for non-Hodgkin's lymphoma at Seoul National University Hospital between March 1989 and March 1990 were studied prospectively. Routine physical examination, complete blood count, chest X-ray and pulmonary function test including DLco were done at initial diagnosis, then every 2 cycles and at restaging, and 1 month after the last treatment. The results were as follows: 1) Carbon monoxide diffusing dapacity (DLco) decreased from the 6th cycle (cumulative dose was average 347 u) and persisited thereafter, but the decrement was not dose-dependent. 2) There were no interval changes in forced vital capacity (FVC), forced expiratory volume 1-second (FEV1), FEU1/FVC, mean forced expiratory flow during middle half of the FVC (MEF), and MEF/FVC. 3) Based on radiological critieria, bleomycin-induced pulmonary toxicity developed in 1 patient (6.7%). At this point, the cumulative dosage of bleomycin was 312 u and DLco decreased by 57%. 4) If the predictive critieria was determined as 55% decrement of DLco, the false positive rate was 66.7%. In this study, no parameters were found to predict bleomycin-induced pulmonary toxicity. In conclusion, DLco is not a universally sensitive predictor of bleomycin-induced pulmonary toxicity, but may be a preceding parameter. It is recommended that for all patients who are administered over 300 u of bleomycin, a periodic physical examination, DLco and chest X-ray should be done for early detection of bleomycin-induced pulmonary toxicity. .
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