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서석배 ( Suk Bae Suh ),노인호 ( In Ho Roh ),김광중 ( Kwang Joong Kim ),이종주 ( Chong Ju Lee ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.2
Cutaneous metastasis from internal malignacy is recognized but infrequently occuring manifestation. The prostatic carcinoma rarely acts as a primary source for cutaneous metastasis. We report a case of cutaneous metstasis from prostatic carcinoma. A 82-year-old male presents multiple painless erythematous nodules on suprapubic area, having an episode of surgical removal of prostate carcinoma two years ago. Histologic finding shows atypical anaplastic cell infiltration at the dermis and subcutaneous tissue, forming dermal tumor island, and have features similar to primary prostatic carcinoma. Immunohistochemical staining for prostate specific antigen shows positive reaction within cells, can assist in localization of the metatatic adenocarcinoma to a prostate origin. (Kor J Dermatol 1996;34(2): 317-321)
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대상포진 환자에서 T 림프구 아형 및 회상항원에 대한 관찰
서석배,김광중,이종주 ( Suk Bae Suh,Kwang Joong Kim,Chong Ju Lee ) 대한피부과학회 1997 大韓皮膚科學會誌 Vol.35 No.6
Background: The incidence of herpes zoster is higher among patients with impaired cell mediat,ed immunity. Herpes zoster skin lesions frequently become more severe and run a more protracted course in such patients. Objective : This study aimed to firstly elucidate whether there are changes in cell mediated immunity, even in immunocompetent, patients with herpes zoster, and secondly to investigate relationships between these change and the clinical appearance of herpes zoster. Methods : T lymphocyte sub;et,s in peripheral blood and delayed hypersensitivity reactions using the Multitest CMI kit were measured in 33 healthy patients with herpes zoster and 28 controls. Results : As compared with controls, there was a slight decrease in percentages of CD4 lym-phocytes, a significant decr eas in percentages of CD8 lyrnphocytes, and a slight increase in CD4/ CD8 ratios in the acute phasr of herpes zoster. The percentages of CD3 lymphocytes were also significantly decreased. Baseg i)n the severit,y of the skin lesion, t.her e was a significant increase in duration of acute herpetic pain. However, there were no signigicant differences in percentages of T lymphocyte subsets based on the severity of skin lesion and duration of acute horpetic pain. In delayed hypersensitivity rea.tions with the Multitest CMI kit, the intensity and frequencies of positive reactions were signific,intly decreased in the patients group. Conclusions . There are sigr.ificant changes in peripheral blood T lymphocyte subsets and delayed hypersensitivity reactions even in other wise healthy patients. (Korean J Dermatol 1997;35(9): 1066-1073)
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