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이제환 ( Lee Je Hwan ),박선양 ( Park Seon Yang ),계경채 ( Gye Gyeong Chae ),정철원 ( Jeong Cheol Won ),신현춘 ( Sin Hyeon Chun ),이진학 ( Lee Jin Hag ),양성현 ( Yang Seong Hyeon ),김병국 ( Kim Byeong Gug ),김노경 ( Kim No Gyeon 대한내과학회 1993 대한내과학회지 Vol.44 No.3
Background : The formation of deep vein thrombosis reflects a balance between the effects of thrombogenic stimuli and a series of protective mechanisms. Substantial progress has been made in the last several decades in identifying hereditary and acquired risk factors predisposing to deep vein trombosis. Even so, a large number of patients still have no identifiable underlying cause for recurrent venous thrombosis. Elucidation of specific predisposing factor (s) is required for proper management of thrombosis. For the Korean patients, these factors have not been well characterized. Methods : We analyzed clinical profiles of the patients with venous thromboembolism and investigated the laboratory abnormalities known to be associated with increased risk of thrombosis. Results : 1) The male-female ratio was 1 : 1. 13 and age distribution showed 24.7% in fifth decade, 22.4% in sixth, 18.8% in fourth, 11.7% in third, 10.6% in seventh, 7.1% over 70 years old, and 4.7% under 20 years. 2) The thromboses were most commonly located in lower extremities (74.1%), and intraabdominal thromboses were 16 cases (18.8%), thromboses of upper extremities 4 cases (4.7%), superior vena cave thrombosis 1 case (1.2%) and pulmonary embolism without evidence of deep vein thrombosis 1 case (1.2%). Thirty-four percent of the cases were diagnosed as having pulmonary embolism. 3) The clinical risk factors for venous thromboembolism were old age(17.0%), malignancy (15.3%), prior history of venous thromboembolism (12.9%), postoperative state (10.6%), immobilization (8.2%), hyperlipidemia (5.9%), systemic lupus erythemato년 (4.7%), obesity (4.7%), stasis (4.7%), nephrotic syndrome (3.5%), diabetes mellitus (3.5%), Behcet`s disease (2.4%), estrogen (2.4%). Twenty-nine percent of the cases had no indentifiable clinical risk factors. 4) The laboratory abnormalities associated with venous thromboembolism were increase of anticardiolipin antibody (19.4%), decrese of protein C activity (16.7%), decrease of protein S (free form) antigenicity (10.7%), decrease of antithrombin Ⅲ activity (5.9%), decrease of tissue-type plasminogen activator (t-PA) (22.7%), increase of plasminogen activator inhibitor type 1 (PAI-1) (29.4%) and decrease of fibrinolytic activity (42.4%). Conclusion : Clinical and laboratory risk factors have been determined in 85 patients with deep vein thrombosis and/or pulmonary embolism in Korea. Major clinical risk factors for venous thromboembolism included old age, malignancy, prior history, postoperative state and immobilization. Among the laboratory abnormalities associated with venous thromboembolism, increase of PAI-1 and/of decrease of t-PA, and increase of anticardiolipin antibody were most frequently observed.