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임상연구 : Propofol을 이용한 마취유도 시 기관내삽관에 의한 혈역학적 변화에 대한 Fentanyl과 Remifentanil의 효과
김형태 ( Hyung Tae Kim ),김철근 ( Cheal Kun Kim ),이준학 ( Jun Hak Lee ),권영은 ( Young Eun Kwon ),이정우 ( Jeong Woo Lee ),김동찬 ( Dong Chan Kim ) 대한마취과학회 2006 Korean Journal of Anesthesiology Vol.51 No.5
Background: Laryngoscopy and endotracheal intubation cause hemodynamic changes such as hypertension and tachycardia. Adjuvant fentanyl administration have been used to reduce the hemodynamic changes. Remifentanil, a newly developed ultra short acting opioid, has recently been used to reduce the hemodynamic changes. This study investigated the effects of fentanyl and remifentanil on hemodynamic responses to laryngoscopy and endotracheal intubation. Methods: Sixth ASA class I or II patients who scheduled for elective surgery were divided randomly into 3 groups. Each patient received normal saline, fentanyl 1.5μg/kg or remifentanil 1.5μg/kg, respectively. Predetermined drugs for each group were administered over 30 seconds after induction of anesthesia with TCI of propofol effect site target concentration 4.0μg/ml and rocuronium 1.0 mg/kg. Laryngoscopy and endotracheal intubation was carried out and systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP) and heart rate (HR) were measured baseline (initial), before intubation (BI) and during 5 minutes after intubation (I1 to I5). Results: In the fentanyl group, I1 HR value was significantly higher than baseline. In the remifentanil group, SBP and MAP were significantly lower than baseline during post-intubation period. Fentanyl and remifentanil groups show lesser hemodynamic changes than those in the control group. There were no significant differences of hemodynamic changes between fentanyl and remifentanil group. Conclusions: Fentanyl and remifentanil can attenuate hemodynamic responses after laryngoscopy and endotracheal intubation. (Korean J Anesthesiol 2006; 51: 552~7)
방경환(Kyong-Hwan Bang),김영창(Young-Chang Kim),이정우(Jung-Woo Lee),조익현(Ick-Hyun Cho),홍지은(Chi-Eun Hong),현동윤(Dong-Yun Hyun),김장욱(Jang-Uk Kim) 한국육종학회 2020 한국육종학회지 Vol.52 No.S
Artificial selection of ginseng has been practiced since Hwangsook (with yellow pericarp and a green stalk, and was developed from a landrace parent) and Cheonggyeong (with red pericarp) were selected as breeding lines in 1926. Systematic research into ginseng breeding, however, started in earnest in the 1960s when the Central Research Institute of Monopoly and Technology (CRIMT) was established, and the Korean Ginseng Experiment Station was organized under the CRIMT. Research into variant characteristics, resource collections, and genetic evaluations began around this time. With the establishment of the Korean Ginseng Institute in the 1970s, studies involving pedigree selection, cataloguing of agricultural traits of genetic resources, generation shortening by tissue culture, and heritability assessments were conducted. In the 1980s, regional adaptation tests were carried out on breeding lines, focusing on ginseng-producing districts. In the 1990s, research was performed on seed multiplication for variety diffusion, effective components and processing quality, and cross breeding. Foreign ginsengs were introduced for interspecies hybridization, and studies were conducted using genetic engineering techniques. Since the 2000s, applications have been made to patent different ginseng cultivars. Currently, 32 cultivars are registered at the Korea Seed & Variety Service. Future goals for ginseng breeding include developing climate change- and disaster-resistant, consumer-oriented, high-performance cultivars. Therefore, it is necessary to develop technologies for distributing new cultivars by collecting and evaluating genetic resources, and cross breeding and performing mass propagation using these resources.
Evaluating Cold Resistance of Ginseng Germplasm using Chlorophyll Fluorescence
Ick Hyun Jo(조익현),Woo Jong Jang(장우종),Jung Woo Lee(이정우),Sung Min Jung(정성민),Na Young Kwon(권나영),Young Chang Kim(김영창),Chi Eun Hong(홍지은),Kyong Hwan Bang(방경환),Jang Uk Kim(김장욱),Dong Hwi Kim(김동휘) 한국약용작물학회 2022 한국약용작물학회 학술대회논문집 Vol.2022 No.1
임상연구 : 노인 환자에서 Sevoflurane-Remifentanil 마취유도 시 Glycopyrrolate, Atropine 투여가 혈역학적 변동에 미치는 영향
박준범 ( Joon Beom Park ),조혜란 ( Hye Ran Cho ),이준학 ( Jun Hak Lee ),권영은 ( Young Eun Kwon ),이정우 ( Jeong Woo Lee ),김동찬 ( Dong Chan Kim ) 대한마취과학회 2006 Korean Journal of Anesthesiology Vol.51 No.5
Background: This study was conducted to determine the effect of glycopyrrolate or atropine on attenuating hemodynamic responses such as bradycardia and hypotension during anesthetic induction with remifentanil and sevoflurane in elderly patients, in a randomized placebo-controlled double blinded manner. Methods: 60 patients over 65 years with ASA physical status 1 or 2 were allocated to one of three groups of 20 each. Each group received saline placebo (group C) or glycopyrrolate 4μg/kg (group G) or atropine 0.5 mg (group A) immediately after induction of anesthesia, and then remifentanil 1μg/kg bolus was given over 30s. Mean arterial pressure (MAP) and heart rate (HR) were measured before anesthetic induction, before intubation, and during 5 minutes after intubation at 1 minute interval. Results: MAP remained stable and HR increased significantly 1 min after intubation in all groups. MAP decreased significantly during 2-5 minute after intubation in all groups. HR decreased in the group C, remained stable in the group G, and increased in the group A significantly during 3-5 minute after intubation. Hypotension (systolic blood pressure < 90 mmHg checked twice) occurred in 8 patients in the group C, 1 patient in the group G, and none in the group A. Conclusions: Glycopyrrolate and atropine attenuated the hemodynamic responses to laryngoscropy and intubation during anesthetic induction with remifentanil 1μg/kg bolus dose and sevoflurane. (Korean J Anesthesiol 2006; 51: 558~62)
만성 요통에 대한 침치료의 단기 효과에 관한 연구: 무작위 대조군 연구
권영달 ( Young Dal Kwon ),이상규 ( Sang Gyu Lee ),김동은 ( Chong Woo Lee ),최선미 ( Soon Kwan Jung ),이정우 ( Dong Eun Kim ),정순관 ( Seon Mi Choi ) 한방재활의학과학회 2007 한방재활의학과학회지 Vol.17 No.2
목적 : 만성요통에 있어서 침치료의 효과에 대해 연구하고자 하였다. 방법 : 포함기준은 연령 20세 이상의, 3개월 이상 된 요통을 가진 환자를 대상자로 하였고, 척추종양, 감염, 신경학적 결손과 같은 척추질환은 대상에서 제외시켰다. 단순 요추부 X-선 사진과 CT를 촬영한 후, 전체 57명의 환자 중 50명을 선정하여 각각 25명씩, 수기침을 처치받는 군과 표피자극침을 처치받는 군으로 무작위 배정하였다. 수기침 군은 20분 동안 총 14개의 경혈에 得氣를 이용한 처치를 받았고, 표피자극침 군은 20분 동안 총 14개의 비경혈점에 표피자극만의 처치를 받았다. 침치료는 한 주에 3번씩, 4주 동안 시행되었다. 처치 전과 처치 2주 후, 4주 후에 VAS(Visual Analogue Scale), RDQ(Roland Disability Questionnaire), PGA(Patient Global Assessment)를 측정하였고, 처치 전과 처치 4주 후에 DT(Digital Thermography)를 측정하였다. 자료는 Repeated Measure ANOVA와 ITT를 이용하여 분석하였고, P<0.05인 경우를 통계적으로 유의하다고 보았다. 결과 : 총 3명의 탈락자가 있었는데 수기침 처치 군에서 1명, 표피자극침 처치 군에서 2명이 있었다. 수기침 처치 군에서, 처치 전, 처치 2주 후, 4주 후의 VAS 점수는 통계적으로 유의한 감소를 보였고(19.24±19.74, P=0.000), RDQ 점수 또한 감소하였으나 통계적으로 유의하지 않았다(1.16±4.85, P>0.05). 표피자극침 처치 군에서 처치 전, 처치 4주 후의 VAS 점수는 통계적으로 유의한 감소를 보였으나(15.75±20.73, P=0.000), 처치전, 처치 2주 후의 VAS 점수의 감소는 통계적으로 유의하지 않았고(P>0.05), RDQ 점수 또한 감소하였으나 통계적으로 유의하지는 않았다(1.84±5.25, P>0.05). 수기침 처치군과 표피자극침 처치군 간에, VAS와 RDQ 점수의 차이는 없었다. 각 군의 시기별 DT 측정치와 PGA 점수는 통계적으로 유의한 차이가 없었고 두 군 간의 비교에 있어서도 마찬가지 결과를 보였다. 총 3명의 대상자(수기침 처치군에서 1명, 표피자극침 처치군에서 2명)는 처치 후의 경미한 부작용으로서 피로감을 호소하였으나, 심각한 부작용을 호소하는 대상자는 없었다. 결론 : 단기간의 침치료는 만성요통에 있어 효과적이고 안전한 치료방법이다. 그러나 본 연구에서 침치료는 표피자극침 처치에 비해 뛰어난 효과를 보여주지는 않았다. 앞으로 다 기관에서 추후 추적검사를 포함한, 엄격한 임상 연구가 진행되어야 할 것으로 사료된다.