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마우스에서 BR92021(정제 브이아이 장티푸스 백신)의 감염 방어 효과
임상민(Sang Min Lim),정한선(Hahn Sun Jung),이윤경(Youn Kyeong Lee),조증근(Zeung Keun Cho),김상린(Sang Lin Kim),이영순(Yong Sun Lee) 한국독성학회 1999 Toxicological Research Vol.15 No.3
This study was performed to confirm the immunological efficacy of BR92021, vi polysaccharide typhoid vaccine, in mice. The BR92021 producing strain was less pathogenic than the challenging organism, S. typhi ty2 N4446. BR92021 completely protected the death caused by S. typhi ty2 at above 1.25 ㎍/0.5 ml/dose vaccinized by one time. At the optimally effective dose of 25 ㎍/0.5 ml of BR92021, one immunization was necessary for complete protection against S. typhi ty2-induced death. In potency test, we injected S. typhi ty2 N4446 (LD50=7.9)for the purpose of challenge to immunized mice. When injected to mice, the number of bacteria was about 1,000 CFU/0.5 ml, we observed challenged mouse for 3 days and calculated the ED50 by probits method. It was 0.037 (BR92021 ,lot No. 980001), 0.036 (BR92021, lot No. 980002), 0.032 (BR92021, lot No. 980003) and 0.045 (reference standard) ㎍/0.5 ml/mouse. This result showed that BR92021 vaccine was effective for the protection from desease caused by S. typhi ty2 infection.