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폐쇄성 수면무호흡증환자의 혈장 단백에 대한 프로테옴 분석
이승관(SeungGwan Lee),이창규(ChangKyou Lee),윤대위(DaeWe Yoon),성은미(EuenMe Sung),김진관(JinKwan Kim),신철(Chol Shin),이성호(SungHo Lee) 고려대학교 보건과학연구소 2003 보건과학논집 Vol.29 No.2
Obstructive Sleep Apnea(OSA) is characterized by episode of complete or partial pharyngeal obstruction during sleep and deeply related to cardiovascular disease and cerebrovascular disease. Many studies show that Hypoxia, Hypertension, and the production of superoxide produced by elevated homocysteine concentration may damage to vascular endothelium. In this study we performed proteomic-based approach to characterize the plasma protein associated with wound healing mechanism. First, overnight polysomnographic study was carried out in sleep laboratory, using standard recording techniques. Five cases of OSA patients and 5 normal controls were analyzed by two dimensional gel electrophoresis (pH 3-10NL, 8-18% gradient). Protein spots were cut from 2 -D gels stained by Coomasie blue, and were identified by using matrix-assisted laser desorption ionization mass spectrometry(MALDI-MS). The results were compared with those of paired normal controls. Comparative analysis of the respective spot patterns in 2DE shows that Vitronectin which plays an important role in repairing wounded vessel was increased. Following protein was also increased in OSA patients : Ig alpha-1 chain C region
Al-Si-Cu합금의 용체화 처리 온도에 따른 Al2Cu 용해와 용융 현상
이승관 ( Seunggwan Lee ),김정석 ( Chungseok Kim ) 한국열처리공학회 2022 熱處理工學會誌 Vol.35 No.1
In this study, dissolution and melting phenomenon of the Al<sub>2</sub>Cu was studied for the high-strength Al- Si-Cu aluminum alloy in automobile component. The Solution heat treatment was performed at 480℃ and 510℃ for 4hours. Microstructure analysis of the specimen was performed using the optical micrograph and scanning electron microscope for qualitative and quantitative analysis of various phases, the chemical composition of secondary phases was achieved by energy dispersive spectroscopy (EDS) and electron probe micro analysis (EPMA). As a result of the electron probe micro analysis, a plate like Al<sub>2</sub>Cu phase was observed, and eutectic Si phase was observed of a coarsen plate shape. At a temperature of 510, necking phenomenon occurs in a specific part of plate like Al<sub>2</sub>Cu, and it is segmented and dissolved in the Al matrix. When the temperature of the alloy exceeds the melting point of Al<sub>2</sub>Cu, incipient melting occurs at the grain boundary of undissolved Cu particles. (Received January 14, 2022; Revised January 18, 2022; Accepted January 19, 2022)
이창규(ChangKyou Lee),이승관(SeungGwan Lee),조경진(KyungJin Cho),최명재(MyungJae Choi),이국성(KookSung Lee) 고려대학교 보건과학연구소 2006 보건과학논집 Vol.32 No.1
The license examinations for health and medical fields have been developed. the classical item analysis, however, has been used the test system and most of the tests are paper and pencil test so far. The relative difficulty of the tests depend on intellectual levels of candidates and few solutions for the changes of the relative difficulty of the test often lead to various test contingences. The IRT was a logic theory for the CAT. The data for relative difficulty, discrimination, guessing parameter were calculated by IRT and Item Banking was made from the calculated data. Through the study we have finally confirmed that the big step program has its ability to check the validities of items from preparing or scoring to item analysis.
의사, 간호사 국가시험의 문항반응이론에 의한 CAT시스템 개발에 관한 연구
이창규(ChangKyou Lee),이은일(E.I. Lee),이숙자(S.J. Lee),박은숙(E.S. Park),박영주(E.S. Park),박종성(J.S. Park),이승관(SeungGwan Lee),조경진(KyungJin Cho) 고려대학교 보건과학연구소 2005 보건과학논집 Vol.31 No.2
Tests are divided into two major groups by their objectives, a normal referenced test for entrance examinations and a criterion reference test for licenses and certifications. The license examinations for health and medical fields have been developed. The classical item analysis, however, has been used for the test system and most of the tests are paper and pencil test so far. The relative difficulty of the test depends on intellectual levels of candidates and few solutions for the changes of the relative difficulty of the test often lead to various test contingencies.<BR> From the beginning of 21st century, advanced countries have adopted the Computer Adaptive Test (CAT) for license and certification in the field of health and medical specialist as well as in other fields. The Item Response Theory (IRT) was a basic theory for the CAT.<BR> The data for relative difficulty, discrimination, guessing were calculated by IRT and Item Bank was made from the calculated data. Computer Based Test using the item bank was carried into effect and more items are banked and calculated continuously. Computerized Adaptive Test using information communication network, e.g. internet and computer lab, was developed. The CAT system using information communication network is able to use license examination as well as education for the students in medical, nursing, and health sciences.
이창규(ChangKyou Lee),이승관(SeungGwan Lee),조경진(KyungJin Cho),장철수(ChulSoo Chang),신숙희(SookHee Shin) 고려대학교 보건과학연구소 2006 보건과학논집 Vol.32 No.1
In spite of their demerits the classical methods for item analysis have been used so far without distinct alternatives. However, various innovative item analysis methods using computers were emerging and the analysis methods are still being advanced everyday. In some advanced countries they adopt CAT system in certifying or licensing examinations in the areas of social sciences, natural sciences, engineering and medical sciences. For the CAT executions the test item banking should go side by side with the strict selection of items through the Differential Item Functioning. Since the authors checked the DIF through M-H method and got desirable results, we want to report them here.
Graph Coloring Problem 해결을 위한 Ant Colony System의 생성함수 성능비교에 관한 연구
안상혁(SangHuck Ahn),이승관(SeungGwan Lee),정태충(TaeChoong Chung) 한국정보과학회 2001 한국정보과학회 학술발표논문집 Vol.28 No.2Ⅱ
그래프 착색 문제(Graph Coloring Problem)는 인접한 노드 (Vi, Vj)가 같은 색을 갖지 않도록 그래프 G의 노드 V에 색을 배정하는 문제로, NP-hard 문제로 잘 알려져 있다. 또한 최근까지 그래프 착색 문제의 최적 해를 구하기 위하여 다양한 접근 방식들과 해법들이 제안되고 있다. 본 논문에서는 기존의 그래프 착색 문제의 해법으로 잘 알려진 Greedy algorithms, Simulated Annealing. Tabu search 등이 아닌 실세계에서 개미들이 자신의 분비물을 이용하여 경로를 찾는 Ant System을 개선하여 새롭게 제안한 Ant Colony System(ACS) 알고리즘으로 해를 구하는 ANTCOL을 소개하고, ANTCOL에서 DSATUR, Recursive Largest First(RLF) 등의 방식을 사용한 기존 생성 함수들과 RLF를 개선하여 제안한 eXtend RLF방식을 사용한 생성 함수를 비교, 평가하고자 한다.
김현 ( Hyun Kim ),이승관 ( Seunggwan Lee ),정태충 ( Taechoong Chung ) 한국정보처리학회 2004 한국정보처리학회 학술대회논문집 Vol.11 No.2
먹이추적문제(prey pursuit problem)는 가상 격자로 이루어진 공간 내에 다중의 에이전트를 이용하여 먹이를 포획하는 것이다. 에이전트들은 먹이를 포획하기 위해 30x30으로 이루어진 격자공간 (gride)안에서 기존 제안된 지역 제어, 분산 제어, 강화학습을 이용한 분산 제어 전략들을 적용하여 먹이를 포획하는 전략을 구현하였다. 제한된 격자 공간은 현실세계를 표현하기에는 너무도 역부족이어서 본 논문에서는 제한된 격자공간이 아닌 현실 세계와 흡사한 무한 공간 환경을 표현하고자 하였다. 표현된 환경의 모델은 순환구조(circular)형 격자 공간이라는 새로운 실험 공간이며, 새로운 공간에 맞는 전략은 에이전트와 먹이와의 추적 관계를 방향 벡터를 고려한 모델로 구현하였다. 기존 실험과는 차별화된 환경에서 에이전트들은 휴리스틱을 통한 학습을 할 수 있다는 가정과 먹이의 효율적 포획, 충돌문제 해결이라는 결과를 얻었다.