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장병욱,이도섭 한국농공학회 1993 韓國農工學會誌 : 전원과 자원 Vol.35 No.4
A series of laboratory tests was performed with soil-columns which were compacted with sands and different amount of silt collected from the mid-stream of Gumgang, Korea. A known degree of concentration of PCP(Pentachlorophenol) was poured into the soil-columns and concentration of PCP was monitored and analyzed with time and depth. The results of the study are summarized as follows : 1. PCP was transported into soil along with the movement of moisture under gravitational force. The amount of PCP transported through soil or absorbed by soil varied with soil types. 2. The great amount of PCP was remained at 4~8cm section for the specimen No.2 and at 0~4cm section for the specimen Nos. 3 and 4. Based upon this result it is said that the amount of silt between 30 and 40% may be a threshold value for PCP transported through soil. 3. The amount of PCP remained in the specimen Nos. 2, 3 and 4 is greater than that in the specimen No.1 due to high specific surface of silt and high attraction force between PCP and silt particles in the specimen Nos. 2, 3 and 4. 4. It is said that groundwater under highly permeable soil layer such as specimen No.1 is easily polluted by PCP. That is because the PCP is basically migrated with water under the gravitational force.
이보경,이도섭,하소영,박세원,정이숙 대한약학회 2014 약학회지 Vol.58 No.5
In this study, we investigated whether the mixtures of onion water extract and aloe ethanol extracts have anti- platelet activities. The mixtures inhibited collagen- and thrombin-induced rat platelet aggregation in vitro. Additionally, the oral administration of the mixtures inhibited platelet aggregation induced by collagen ex vivo but not prolonged mouse tail vein bleeding time in vivo. These results suggest that the combination of onion and aloe extracts has a potential to be a preventive agent against platelet-mediated disorders.
전우진(Woo-Jin Jeon),이도섭(Do-Seop Lee),손서연(Suh-Youn Shon),서윤지(Yun-Ji Seo),연승우(Seung-Woo Yeon),강재훈(Jae-Hoon Kang) 한국식품과학회 2016 한국식품과학회지 Vol.48 No.4
선행연구(12,13)에 따르면 10주간 ID1216을 투여한 비만 마우스에서 체중과 체지방이 감소하였고 이는 SIRT1-PGC1α의 발현을 조절하여 나타나는 것으로 확인하였다. 본 연구는 SIRT1-PGC1α-PPARα의 하위 기전인 UCPs, ACO, aP2의 발현 조절에 ID1216이 영향을 미쳐 그 효과를 나타내는 것을 추가로 확인한 것에 의미가 있다. 또한 10주간 ID1216을 투여한 비만 마우스의 혈액 분석 결과에서도 혈중 중성지방, LDL, HDL total cholesterol등의 혈중 지방질 수치가 개선됨과 동시에 free fatty acid의 농도는 감소하였는데 이는 ID1216이 HSL과 같은 지방질분해효소의 활성을 조절하여 중성지방의 분해과정에 관여하기는 하나 에너지 대사와 지방산 산화 과정에도 복합적으로 관여하여 최종적으로 나타내는 비만 대사 조절 효과에 의한 것으로 판단된다. 따라서 ID1216은 SIRT1-PGC1α-PPARα pathway를 촉진시켜 세포와 조직 수준에서 열발생(thermogenesis)에 관여하는 유전자인 UCP1, UCP2, UCP3의 발현을 증가시켰고 β-oxidation에 관여하는 유전자인 ACO와 aP2의 발현도 증가시켰으며 또한 지방분해(lypolysis)에 관여하는 유전자인 ATGL과 HSL의 발현을 증가시키는 분자생물학적 기전을 나타내어 체지방 감소 효과를 나타내는 것으로 확인되었다. In previous studies, we confirmed that the ethanol extract of Polygonatum sibiricum (ID1216) has anti-obesity effects on high-fat diet-fed mice. To identify the obesity-related genes affected by ID1216, we studied its effects both in vivo and in vitro. In mice, single administration of ID1216 increased the expression of obesity-related genes including sirtuin1 (SIRT1), peroxisome proliferator-activated receptor γ coactivator 1α (PGC1α) and peroxisome proliferator-activated receptor α (PPARα) compared to that in mice administered the vehicle; their downstream genes (uncoupling proteins, acyl-CoA oxidase, adipocyte protein 2, and hormone-sensitive lipase) were also increased by ID1216. In fully differentiated 3T3-L1 adipocytes, ID1216 showed the same effects on anti-obesity genes as those in the animal model. Based on these results, we propose that ID1216 has anti-obesity effects by regulating the SIRT1-PGC1α-PPARα pathway and their downstream genes, thereby controlling energy and lipid metabolisms.
불포화(不飽和) 토양(土壤)에서의 PCP의 이동(移動)에 대한 연구(硏究)
장병욱 ( Chang Pyoung Wuck ),이도섭 ( Lee Do Seob ) 한국농공학회 1993 韓國農工學會誌 : 전원과 자원 Vol.35 No.4
A series of laboratory tests was performed with soil-columns which were compacted with sands and different amount of silt collected from the mid-stream of Gumgang Korea. A known degree of concentration of PCP(Pentacloraphenol) was poured into the soil-columns and concentration of PCP was monitored and analyzed with time and depth. The results of the study are summarized as follows : 1. PCP was transported into soil along with the movement of moisture under gravitational force. The amount of PCP transported through soil or absorbed by soil varied with soil types. 2. The great amount of PCP was remained at 4~8cm section for the specimen No.2 and at 0~4cm section for the specimen Nos. 3 and 4. Based upon this result it is said that the amount of silt between 30 and 40% may be a Threshold value for PCP transported through soil. 3. The amount of PCP remained in the specimen Nos. 2, 3 and 4 is greater than that in the specimen No.1 due to high specific surface of silt and high attraction force between PCP and silt particles in the specimen Nos. 2, 3 and 4. 4. It is said that groundwater under highly permeable soil layer such as specimen No. 1 is easily polluted by PCP. That is because the PCP is basically migrated with water under the gravitational force.
고지방 식이 유도 비만 마우스 모델에서 황정 추출물의 지방질 및 에너지 대사 관련 유전자에 대한 효능 연구
전우진(Woo-Jin Jeon),김지영(Ji-Young Kim),오익훈(Ik-Hoon Oh),이도섭(Do-Seop Lee),손서연(Suh-Youn Shon),서윤지(Yun-Ji Seo),연승우(Seung-Woo Yeon),강재훈(Jae-Hoon Kang) 한국식품과학회 2017 한국식품과학회지 Vol.49 No.2
황정 주정 추출물 ID1216의 고지방 식이 유도 비만 마우스에서의 체중 증가 억제 효과에 대한 분자생물학적 기전을 확인하고자 단백질과 mRNA 수준에서 지질 및 에너지 대사 관련 유전자들의 발현 변화를 관찰하였다. 본 연구에서 확인된 지표들 간의 상호 작용 및 ID1216의 조절 여부에 관해 Fig. 10에 나타내었다. 실험 결과 ID1216은 고지방 식이 유도 비만 마우스에서 체중 증가 억제를 나타내었으며, 비만 대사 관련 pathway의 상위 유전자로 사료되는 SIRT1과 AMPK의 발현을 조절하는 것으로 나타났다. 활성화된 SIRT1과 AMPK는 PGC1α의 활성화에 관여하고, 이를 통해 열 발산 대사와 관련된 UCP 단백질과 핵 수용체 단백질인 PPARα의 발현이 백색지방, 갈색지방, 간 및 근육에서 증가되는 것이 확인되었다. 각 조직 별로 RT-PCR을 진행한 결과에서는 PPARα의 하위 유전자인 aP2, ACO, Acadl, Acadm, CPT1a, CPT1b의 mRNA 발현 수준을 향상시켜 주어 ID1216이 지방산 산화 대사인 β-oxidation의 활성화에 기여할 가능성을 보여주었다. 이와는 별개로 ID1216은 중성지질을 분해하는 것으로 알려진 ATGL의 mRNA 발현 또한 증가시키는 것으로 확인되었다. 본 연구를 통해 ID1216이 조직에 따라 지질 및 에너지 대사와 관련된 인자의 발현에 영향을 주는 체중 조절에 효과적인 소재임을 알 수 있었다. 또한 비만 치료제와의 기전적 차별성과 생약 특유의 섭취 안전성을 특징으로 하는 체중 또는 체지방 조절기능성 소재로의 활용 가능성도 충분히 가지고 있음을 확인할 수 있었다. In this study, factors involved in lipid and energy metabolism following treatment with ethanolic extract of the Polygonatum sibiricum rhizome (ID1216) were evaluated in high-fat diet-induced obese mice. ID1216-treated mice showed a significant reduction in weight gain compared to non-treated mice. ID1216 treatment increased the protein levels of AMP-dependent protein kinase, sirtuin1, peroxisome proliferator-activated receptor γ coactivator 1-α (PGC1α), peroxisome proliferator-activated receptor α (PPARα) and uncoupling proteins in the adipose tissue, liver and muscle compared to vehicle treatment. Analysis of downstream signals of the sirtuin1 PGC1α-PPARα pathway showed that ID1216 regulates the expression of β-oxidation related genes such as acyl-CoA oxidase, carnitine palmitoyltransferase1, acyl-CoA dehydrogenase and adipocyte protein 2. In addition, ID1216 increased the expression of adipose triglyceride lipase. These results suggest that ID1216 has anti-obesity effects by regulating the genes involved thermogenesis, β-oxidation and lipolysis in a diet-induced obesity model.