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이경동 ( Kyung Bong Lee ),하태정 ( Tae Joung Ha ),이병원 ( Byong Won Lee ),이종록 ( Jong Rok Lee ),이준 ( Jun Lee ),황선우 ( Sun Woo Hwang ),조동령 ( Dong Young Cho ),남상해 ( Sang Hae Nam ),양민석 ( Min Suk Yang ) 한국응용생명화학회 2003 Applied Biological Chemistry (Appl Biol Chem) Vol.46 No.1
Three terpenoids were isolated from the leaves of Chrysanthemum coronarium L. by silica gel chromatography and recrystalization. The structure of compounds 1, 2, and 3, using various spectroscopic data, were identified as to be terpenoid derivatives of dihydrotulipinolide, loliolide, and 5α, 8α-peroxyergosterol, respectively. The presence of these 3 is the first time reported in this plant. The cytotoxic activity of 5α, 8α-peroxyergosterol showed strong activities against human cancer cell lines such as A549, PC-3, and HCT 116.