http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
임신한 토끼에서 자궁내 감염 유발 후 신속한 항생제 투여 치료의 유용성
은길상 ( Gil Sang Eun ),박교훈 ( Kyo Hoon Park ),윤보현 ( Bo Hyun Yoon ),김암 ( Am Kim ),이진용 ( Jin Yong Lee ) 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.12
Background: Although intrauterine infection, particularly subclinical amniotic infection, is known to increase the risk of preterm labor and delivery, the treatment of this disorder is not well established. Therefore, animal models are desired for elucidating the relationship between antibiotic treatments and pregnancy outcome in case of intrauterine infection, because they are not restricted to ethical concerns, confounding variables, and patient availability. Objective: In the pregnant rabbit model using hysteroscopy-guided intracervical inoculation of E. coli or saline, we investigate 1) the effects of immediate antibiotics (ampicillin-sulbactam) treatment according to inoculum size of E. coli and 2) the effects of timing of administration of antibiotics on pregnancy outcomes after inoculation of E. c.oli. Study Design: Timed-pregnant rabbits underwent hysteroscopy at 21~22 days of gestation(70 %). 1) In the first study, animals were randomly assigned to inoculation either of E. coli (inoculum size 2×10(7) cfu/ml or 2×10(4) cfu/ml) or saline and immediately(within 5 minutes) treated with antibiotics. 2) In the second study, they were assigned to a treatment with antibiotics either 4 hours after inoculation of E. coli 2×10(7)cfu/ml or within 5 minutes after inoculation. Results: 1) Among immediately antibiotics-treated rabbits, E. coli-inoculum groups had significantly fewer live fetuses, more positive cultures of amniotic fluid and/or decidua of fetuses, and more positive cultures in case of live fetuses with respect to inoculum size of E. coli(p<0.001, respectively). And even smaller E. coli-inoculum group(E. coli 2×10(4) cfu/ml) had signficantly lower fetal survival rate and higher positive cultures of amniotic fluid and/or decidua in comparison with control group(p<0.05, respectively). 2) Compared with immediately treated E. coli-inculated rabbits(2×10(7) cfu/ml of E. coli), those who treated from 4 hous after inoculation had significantly fewer live fetuses and more positive cultures of amniotic fluid and/or decidua(p<0.05, respectively), and more positive cultures of amniotic fluid in case of live fetuses (p<0.05, respectively). Conclusion: Earlier antibiotics administration improved pregnancy outcomes in E. coli-inoculated rabbits. However in spite of more increased fetal survival and decreased intrauterine infection rate, there is a possibility of presence of persistent subclinical intrauterine infection in immediately treated and smaller size of E. coli-inoculum group in comparison with noninfected control. When treating with antibiotics, it is needed to observe and monitor closely the presence of persistent subclinical intrauterine infection in patients with intrauterine infection.