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백서에서 Serine Protease 억제제가 난포성숙에 미치는 영향에 대한 연구
윤병구,이진용,Yoon, Byung-Koo,Lee, Jin-Yong 대한생식의학회 1993 Clinical and Experimental Reproductive Medicine Vol.20 No.1
Plasminogen activator (PA)-plasmin system in follicular fluid is involved in the process leading to follicular rupture at ovulation. It is well known that PA is closely associated with cellular differentiation and tissue remodeling on evidences from the study of normal and malignant tissues. This study was designed to ascertain a potential role of PA in the ovarian folliculogenesis. Immature Sprague-Dawley rats were injected with pregnant mare serum gonadotropin, followed by injection of serine protease inhibitor (SPI; mixture of 1 mol/L benzamidine and 1 mol/L amino-caproic acid) into the unilateral ovarian bursa. In the control study, mechanical effect of bursal injection and contralateral ovarian effect SPI were ruled out. Total antral follicular areas relative to total ovarian cross-sectional areas was siginificantly lower in SPI-injected ovary than in saline-injected ovary. SPI injection decreased the relative antral follicular area by 33 % respectively. Electron microscopic finding of granulosa cell in the atretic follicle showed the presence of pyknotic nucleus, blurring of neucleolemma, degeneration of mitochondria and dilation of endoplasmic reticulum. After induction of ovulation with hCG, the number of oocytes released was significantly decreased in SPI-injected oviduct than in saline-injected oviduct. From above results, author discussed that PA may play a role not only in ovulation but also in some processes of folliculogenesis.
윤병구 ( Byung Koo Yoon ),김도관 ( Doh Kwan Kim ),김종원 ( Jong Won Kim ),최두석 ( Doo Seok Choi ),배덕수 ( Duk Soo Bae ),나덕렬 ( Duk Lyul Na ) 대한폐경학회 2003 대한폐경학회지 Vol.9 No.1
배경 및 목적 : 치매는 낙상 가능성의 증가를 통하여 골절의 위험을 높힌다. 진행된 치매에서 관찰되는 골다공증은 영양실조에 의한 2차성 부갑상선항진증과 운동부족이 중요한 원인으로 알려져 있다. 본 연구의 목적은 알쯔하이머병 여성 환자에서 골다공증에 대한 유병률을 조사하는 것이다. 대상 및 방법 : 80명의 알쯔하이머병 환자를 대상으로 하였으며, 초기 치매는 임상치매척도가 1 이하이며, 운동 기능은 정상인 경우로 정의하였다. 과거력상 비외상성 골절의 유무를 조사하였고, osteocalcin과 deoxypyridinoline 등의 골대사지표와 함께 이중에너지 방사선흡수계측법을 이용하여 골밀도를 측정하였다. 결과 : 전체적으로 알쯔하이머병 여성에서 골다공증의 유병률은 58%이었다. 80명중 45명이 초기 치매에 해당하였다. 초기 치매환자에서 골다공증성 골절의 과거력이 38%, 골교체률이 증가한 경우가 72%이었으며 골다공증의 유병률은 62%이었다. 결론 : 여성에서 영양상태와 운동기능이 정상인 초기 알쯔하이머병은 골다공증과 매우 높은 연관성을 보이며, 이는 난포호르몬-알쯔하이머병 가설을 뒷받침하는 연구 결과이다. Background and objective : Dementia is one of the risk factors of fracture via increasing risk of falling down. Osteoporosis occurring in advanced dementia might be causally related to secondary hyperparathyroidism resulting from poor nutrition and physical activity. The purpose of this study is to examine the prevalence of osteoporosis (OP) in patients with Alzheimer`s disease (AD). Materials and methods : Past history of non-traumatic fracture, bone turnover markers such as osteocalcin and deoxypyridinoline and bone mineral density (BMD) using dual energy X-ray absorptiometry were assessed in 80 women with AD. Early AD was defined as clinicla dementia rating scale ≤ 1 and physical activity unimpaired. Results : In general, the prevalence of OP (T value on BMD ≤ -2.5) was 58% in women with AD. Forty-five out of 80 patients belonged to early AD. Thirty-eight percentage of early AD patients had history of fragility fracture, 72% increased bone turnover rate, and 62% osteoporosis. Conclusions : Early AD with normal nutritional status and physical activity might be highly associated with OP, which supports estrogen-AD hypothesis.
폐경 후 여성에서 호르몬 대체요법이 체중 및 체지방 분포에 미치는 영향
윤병구(Byung Koo Yoon),한국선(Kuk Sun Han),안광화(Kwang Hwa Ahn),노정래(Cheong Rae Rho),신경자(Kyung Ja Shin),황종대(Jong Dae Hwang),최두석(Doo Seok Choi),이제호(Ja Ho Lee) 대한폐경학회 2000 대한폐경학회지 Vol.6 No.2
N/A Background and Objective; Obesity, especially central fat distribution, is closely related to cardiovascular risk. Body weight and waist to hip ratio (WHR) tend to increase during the decade following menopause. Hormone Replacement Therapy (HRT) is reported to reduced the risk of cardiovascular disease by half. One of major concerns in women considering HRT is whether it might cause weight gain. Therefore this study was designed to investigate the effect of HRT on body weight and WHR in postmenopausal women. Subjects and Methods; 214 healthy postmenopausal women (estrogen only: 44, combined estrogen-progestin therapy: 170) underwent HRT for alleviation of acute menopausal symptom and prevention of osteoporosis and cardiovascular disease. Body weight and WHR were measured at baseline, 3, 6 and 12 month of HRT. Expected body weight and WHR were calculated from healthy 1,330 control with multiple regression analysis, and corrected value was defined to be measured valued divided by expected one. Results; Formula for expected value was as follows: expected weight =-0.076xAge+2.000xBMI+15.280, expected WHR =0.002xAge+0.011xBMl+0.420. Corrected weight did not change, but corrected WHR decreased significantly at 12 month with HRT. Conclusion; HRT dose not increase body weight and decrease WHR, which would contribute to cardioprotection in postmenopausal women.
자궁내막증 환자에서 혈청 CA 125치 동태에 관한 연구
이진용,윤병구,최영민,신창재,장윤석,Lee, Jin-Yong,Yoon, Byung-Koo,Choi, Young-Min,Sin, Chang-Jae,Chang, Yoon-Seck 대한생식의학회 1990 Clinical and Experimental Reproductive Medicine Vol.17 No.2
Serum CA 125 was measured with immunoradiometric assay in fourty-one patients of endometriosis Serum CA 125 levels (Mean ${\pm}$ SEM, U/ml)in patients with endometriosis were 13.8${\pm}$3.3 in stage I , 17.3${\pm}$3.0 in stage II, 23.4${\pm}$4.9 in stage III, and 64.5${\pm}$13.2 in stage IV, which showed increment according to the stage of endometriosis. Serum levels in stage IV only were significantly elvated than those in control (15.3${\pm}$2.2), and those in advanced stage(III and IV ; 47.1${\pm}$9.5)were significantly higher than those in earlier stages (15.9${\pm}$2.2)and control. The assay revealed a sensitivity of 31.7% and the frequency of elevated levels (> 30.3 U/ml)in stage I, II, III and IV was 9. 1%, 18.8%,33.3%, and 87.5% respectively. Sensitivity in advanced stage was higher than that in earlier stage (64.3% vs. 14.8%). There data suggest that serum CA 125 assay might be a useful diagnostic tool in the advanced stage of endometriosis.