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양측 난관절제술 환자에서 체외수정 후 5회째의 자궁외임신으로 발생한 병합임신 1례
윤내영(Nae Young Youn),윤태기(Tae Ki Yoon) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.9
Although a higher incidence of ectopic pregnancy has been reported after in vitro fertilization(IVF) and embryo transfer(ET), five ectopic pregnancies in one patient is very rare. We experienced a case of combined interstitial and intrauterine pregnancy as fifth ectopic pregnancies after in vitro fertilization and embryo transfer in one patient with history of bilateral salpingectomy due to previous four tubal pregnancies. Repeated transvaginal ultrasound examinations confirmed heterotopic pregnancy. In IVF-ET, bilateral salpingectomy does not remove the risk of interstitial or cornual pregnancy.
이광주,이명환,윤내영,Lee, Kwang-Ju,Lee, Myung-Hwan,Youn, Nae-Young 한국수의병리학회 1998 한국수의병리학회지 Vol.2 No.2
This study was performed to evaluate whether the loss or overexpression of Rb, and overexpression of p53 were prognostic indicators for bladder neoplasia, 52 tumor specimens from transitional cell carcinoma of the urinary bladder were from 42 male and 10 female patients whose age ranged from 30 to 83 years old(mean age; 63,5 years old), This group included 36 superficial and 16 invasive stage bladder tumors, and grades 16-25, p53 was significantly associated with tumor stage and grade(p<0,05 in each), but not with tumor recurrence. Loss of Rb gene expression or Rb overexpression was correlated with stage, but not grade. These results suggested that changes of Rb and p53 expression might play an important role in assessing the aggressiveness of human neoplasms.
반복적 시험관아기 배아이식 실패 환자에서 정맥내 면역글로블린요법
이숙환(Sook Hwan Lee),윤내영(Nae Young Youn),윤태기(Tae Ki Yoon),곽인평(In Pyung Kwak),이은정(Eun Jung Lee),최동희(Dong Hee Choi),한세열(Se Yul Han) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.1
목적: 반복적인 시험관아기-배아이식 실패 환자에서 정맥내 면역글로블린의 효과를 보고자 하였다. 방법: 총 9예의 반복적인 배아이식 실패 환자에서 새로운 시험관아기 시술시 배아이식 직전에 정맥내면역글로블린을 500mg/kg 투여하였다. 결과: 단 1예에서 착상에 성공하였고, 1예는 화학적임신이었다. 시술중 정맥내면역글로블린의 특이한 부작용은 없었다. 결론: 정맥내면역글로블린요법은 반복적 배아이식 실패환자에서 유용한 방법으로 여겨지지 않으나, 향후 면역요법에 대한 지속적인 연구가 필요할 것으로 사료된다. Objective: The implantation failure after embryo-transfer (ET) is a major continuing problem in in vitro fertilization (IVF). This study was undertaken to determine the effectiveness of intravenous immunoglobulin for treatment of individuals experiencing repeated unexplained in vitro fertilization-embryo transfer (IVF-ET) failure. Methods: A total of nine consecutive infertile patients who failed to become pregnant after previous IVF-ET replacing at least three or more normal developed embryos each were included in our study. During the subsequent new IVF-ET cycle, each women received intravenous immunoglobulin 500㎎/㎏ before the embryo transfer. Results: Only one implantation occurred. There were no remarkable side effects. A specific effect of intravenous immunoglobulin for patients with repeated IVF-ET failure could not be demonstrated. Conclusion: High-dose intravenous immunoglobulin may not be useful for patients with repeated failure of embryo transfer.