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최기철(Ki Chul Choi),박종욱(Jong Wook Park),유기섭(Ki Sub Yoo),이민수(Min Su Lee),염충호(Chung Ho Yeum),정유정(You Jeong Chung),이제중(Je Jung Lee),김수완(Soo Wan Kim),김남호(Nam Ho Kim),강영준(Young Joon Kang) 대한내과학회 1996 대한내과학회지 Vol.50 No.2
N/A parameters and BMD of renal transplants. Methods: Using dual-energy X-ray absorptiometry (DEXA), we assessed total body and regional (head, arm, trunk, rib, leg, spine, and pelvis) bone mineral density. Results: 1) Total body BMD of renal transplants was significantly decreased compared with that of normal controls. 2) A separate analysis of BMD in both sexes revealed that males presented marked reduction of BMD compared with the normal controls in the majority of skeletal sites except head and pelvis. Especially, at the spine, their BMD was significantly reduced compared with that of the CRF patients on receiving dialysis in addition to the normal controls. Females also presented reduction of BMD compared with the normal controls in many skeletal sites except head and ribs. 3) The correlations between BMD values and time since renal transplantation and cumulative cyclosporine doses were statistically significant (r=0.46, 0.527, respectively, and p<0.01) in nearly all skeletal sites except head and spine. Conclusion: Our results indicate that significant falls in BMD appear to be inherent to the process of renal transplantation although it achieves the rapid correction of some of the biochemical abnormalities associated with renal failure and that therapeutic strategies to prevent or reduce this damages should be established. In addition, the present study emphasizes the need to pay attention to the further evaluation of correlations between bone loss in renal transplants and some drugs, such as glucocorticoids and cyclosporine.