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- 저자 : 오찬석 ( O Chan Seog ) (검색결과 1 건)
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오찬석 ( O Chan Seog ),박현정 ( Park Hyeon Jeong ),이준영 ( Lee Jun Yeong ),조백기 ( Jo Baeg Gi ),김동욱 ( Kim Dong Ug ),김춘추 ( Kim Chun Chu ) 대한피부과학회 2003 대한피부과학회지 Vol.41 No.10
N/A Background : STI571, which is a selective inhibitor of the BCR-ABL tyrosine kinase, is a promising new drug for the treatment of patients with chronic myelogenous leukemia. But it has been noted that this drug is frequently associated with an adverse cutaneous reaction. Objective : The purpose of this study was to find the clinical and histopathological characteristics of drug eruptions caused by STI571. Method : We reviewed the clinical records of 10 patients diagnosed as drug erupions caused by STI571. Result : 1. The mean age was 36.4 years and it was observed predominantly in females as the sex ratio of 7:3. 2. The most common clinical type was exanthematous eruption(70%), and followed by erythema multiforme-like eruption(20%), urticarial eruption(10%). In most cases(90%), the distribution was generalized, which involved trunk and extremities. 3. The mean latent period was 17.1 days and peak incidence(70%) was noted between 1 and 2 weeks. 4. Commonly associated adverse effects included fever(60%) and diarrhea(30%). 5. Histopathologically, common findings included perivascular inflammatory cell infiltration(100%), eosinophil(80%), exocytosis(80%). Conclusion : Because drug eruptions caused by STI571 are dose-related and develop with a high frequency, we need a careful monitoring of patients who are treated with STI571, especially with a high dose.(Korean J Dermatol 2003;41(10 : 1291~1296)
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