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나재호 ( Na Jae Ho ),김윤하 ( Kim Yun Ha ),오종석 ( O Jong Seog ),신종희 ( Sin Jong Hui ),양정선 ( Yang Jeong Seon ),김철홍 ( Kim Cheol Hong ),조문경 ( Jo Mun Gyeong ),송태복 ( Song Tae Bog ) 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.5
목적 : 정상 임부와 양막파열이 없는 조기분만진통 임부의 질내 과산화수소생성 유산균 양태를 비교하여 조기분만진통과의 상호연관성을 알아보고자 하였다. 연구 방법 : 2001년 7월부터 2002년 2월까지 전남대학교 병원에 내원한 임신 37주 미만의 정상 임부 66명과 양막파열을 동반하지 않은 조기분만진통 임부 30명을 대상으로 하였다. 질내 분비물을 채취 후 질 분비물도말 건사, pH 및 그람염색 Nugent 점수를 측정하였다. 채취한 질내 분비물을 1시간 이내에 Rogosa 한천배지에 접종하여 Lactobacillus를 정상임부 66명에서 187개 군락, 조기진통임부 30명에서 77개 군락을 분리하였고 0.25 mg/mL 3,3`,5,5`-tetramethyl-benzidine와 0.01 mg/mL paclitaxel가 첨가된 MRS 한천배지에 상기에서 분리한 균주를 3μl씩 접종하여 37℃에서 혐기 배양한 후 꺼내어 호기상태에서 30분, 1시간 후에 집락의 과산화수소 생성을 검사하였다. 결과 : 1. 질내 분비물 pH치는 정상 임부 4.06±0.31, 양막파열이 없는 조기분만진통 임부 4.04±0.57로 서로간의 유의한 차가 없었다. 2. 질 분비물 도말 검사상 백혈구 수는 양막파열이 없는 조기분만진통 임부에서 4.46±0.47으로 정상 임부 2.39±0.37보다 유의하게 많았다 (p<0.01). 3. 질 분비물 그람염색 Nugent 점수는 양막파열이 없는 조기분만진통 임부에서 2.34±0.51로 정상 임부 1.21±0.30보다 유의하게 높았다 (p<0.05). 4. 양막파열이 없는 조기분만진통 임부에서 과산화수소생성 유산균은 30분 후 strongly positive 2.6%, weakly positive 2.6%, negative 83.1%로 정상 임부에서 각각 17.1%, 31.6%, 41.7% 보다 유의하게 감소하였다 (p<0.01). 1시간 후에는 양막파열이 없는 조기분만진통 임부에서는 strongly positive 6.5%, weakly positive 7.8%, negative 59.7%로 정상 임부에서 각각 36.9%, 31.6%, 19.8% 보다 유의하게 감소하였다 (p<0.01). 결론 : 질내 숙주방어작용을 하는 과산화수소생성 유산균들의 분포양상이 조기분만진통의 발생에 중요한 역할을 할 것으로 사료된다. Objective : To investigate the possible role of vaginal infection in preterm delivery, we studied characteristics of vaginal discharge related to hydrogen peroxide producing Lactobacillus. Methods : Vaginal specimens were obtained from 66 women with normal pregnancy and 30 women with preterm labor and intact membranes. Vaginal pH, leukocyte counts on wet smear, and scores by Nugent criteria on Gram stain were measured. Lactobacillus were tested for production of hydrogen peroxide using a qualitative assay on a tetramethylbenzidine agar plate after incubated for 30 minutes and 1 hour. One hydrogen eighty-seven hydrogen peroxide-producing Lactobacillus colonies isolated from vaginal fluid of normal pregnant women, and 77 hydrogen peroxide-producing Lactobacillus colonies isolated from it of women with preterm labor and intact membrane. Results : 1. There were no significant differences in vaginal pH between normal pregnant women and women with preterm labor and intact membranes (4.06±0.31 vs. 4.04±0.57, p<NS). 2. Leukocyte levels in vaginal wet smear of women with preterm labor and intact membranes were significantly higher than that of normal pregnant women (4.46±0.47 vs. 2.39±0.37, p<0.01). 3. Nugent score of Gram stained vaginal smear of women with preterm labor and intact membranes were significantly higher than that of normal pregnant women (2.34±0.51 vs. 1.21±0.30, p<0.05). 4. Hydrogen peroxide-producing Lactobacillus levels in vaginal flora of women with preterm labor and intact membranes were significantly lower than that of normal pregnant women incuvated after 30 minutes (strongly positive 2.6%, weakly positive 2.6%, negative 83.1% vs 17.1%, 31.6%, 41.7%, p<0.01) and 1 hour (strongly positive 6.5%, weakly positive 7.8%, negative 59.7% vs 36.9%, 19.8%, p<0.01). Conclusion : Distribution of vaginal hydrogen peroxide-producing Lactobacillus in vaginal flora as defense factors for vaginal infection may have a important role in the pathophysiology of preterm labor.
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건선 환자의 피부에서 Tape Method를 이용한 세균 분포의 연구
류지훈 ( Lyu Ji Hun ),이증 ( Lee Jeung ),손숙자 ( Son Sug Ja ),원영호 ( Won Yeong Ho ),오종석 ( O Jong Seog ) 대한피부과학회 2003 대한피부과학회지 Vol.41 No.8
N/A Background : Psoriasis is one of the relatively common chronic relapsing cutaneous disorders. The etiology and pathogenesis of the psoriatic skin lesion are still unknown. A colonization of microbacterial organisms especially Staphylococcus aureus (S. aureus) have been considered as a factor for development and exacerbation of psoriatic skin lesion. Objectives : The purpose of this study was to observe the bacteria on the skin of the patients with psoriasis and healthy normal persons, and evaluate the relations between bacterial density, S. aureus colonization, and severity of psoriatic skin lesions. Materials & Methods : Twenty two psoriasis patients and 25 healthy normal persons were involved for this study. Psoriasis patients were classified according to a severity estimated by PASI(Psoriasis Area and Severity Index) and activity of psoriatic skin lesions. Microbial sampling by tape method (3M, 5×5 cm) were performed on the psoriatic skin lesion and uninvolved skin in the patients of psoriasis, and on the inner forearm of the normal healthy person. Microbial sampling by a swab were also carried out from nasal mucosa. The tapes were gently contacted on the blood agar plate, and cultured in aerobic condition(30℃) during 2-5 days and the numbers of colony forming unit (CFU) were estimated. Results : The results were as follows; 1. Total numbers of CFU in the lesion and uninvolved skin of psoriasis patients were significantly higher than those of the healthy controls (p<0.05). 2. Total numbers of CFU relatively were correlated with PASI score (p<0.05), but they were not correlated with duration of the disease (p>0.05). 3. The activity of psoriasis was relatively correlated with PASI score and total number of CFU (p<O.05). 4. The number of S. aureus in the psoriatic plaque was not significantly higher than number of uninvolved skin in psoriasis, and number of healthy normal persons (p>0.05). 5. There was a significant correlation between the numbers of S. aureus on the lesional and uninvolved skin and that on the nasal mucosa. (p<0.05). Conclusion : This study demonstrates that bacterial density is significantly higher on the psoriatic skin lesions, which suggests that bacterial colonization on the skin has a role in the development and exacerbation of the psoriatic lesion. (Korean J Dermatol 2003;41(8) : 997~1003)
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