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모르핀의 내성 및 의존성 형성에 미치는 인삼의 효과(III) -인삼의 Protopanaxadiol 분획 및 Protopanaxatriol 분획의 영향-
김학성(Hack Seang Kim),오세관(Sei Kwan Oh),최강주(Kang Ju Choi),이해빈(Hae Bin Lee) 대한약학회 1985 약학회지 Vol.29 No.4
Protopanaxadiol (PD) fraction and protopanaxatriol (PT) fraction were separated from the butanol fraction of panax ginseng roots. Each group of mice was injected with morphine hydrochloride (40mg/kg s.c.) three times at 8 hr intervals for a period of 6 days. PD fraction and PT fraction were injected (25, 100mg/kg i.p.) to mice 1 hr prior to the third morphine injection daily. Inhibition of morphine tolerance was evidenced by the increase in analgesic response to morphine hydrochloride (10mg/kg i.p.) as estimated by the tail flick method. Inhibition of morphine tolerance by PT fraction was effective but there was no remarkable difference in inhibition of tolerance development between control group and PD fraction group.
김학성(Hack Seang Kim),오세관(Sei Kwan Oh),김갑철(Gap Cheol Kim) 한국생약학회 1985 생약학회지 Vol.16 No.1
Intraperitoneal administration of ginseng butanol fraction(GBF) to chronic morphinization in male Sprague-Dawley rats inhibited the development of tolerance to the analgesic effect and hyperthermic action of morphine. Rats were rendered tolerant to morphine by subcutaneous multiple morphine injections for a period of 8 days. The development of tolerance was evidenced by the decreased analgesic response to morphine and inhibition of tolerance by the greater analgesic response. Concomitant administration of morphine with GBF blocked the tolerance to the hyperthermic effect of morphine as evidenced by elevation of body temperature by morphine. Dopamine receptor sensitivity was enhanced in morphine tolerant rats as measured by apomorphine induced in spontaneous motor activity. GBF administration also blocked dopamine receptor supersensitivity induced by chronic morphinization.
박재정(Jae Jeong Park),정구용(Ku-Yong Chung),이정은(Jeong-Eun Lee),염차경(Cha-Kyong Yom),이재길(Jae-Gil Lee),안형준(Hyung Joon Ahn),오세관(Sei-Kwan Oh),성순희(Sun-Hee Sung),강병철(Byung-Chul Kang),한기환(Ki-Hwan Han) 대한외과학회 2008 Annals of Surgical Treatment and Research(ASRT) Vol.75 No.5
Purpose: We designed a pig to canine liver xenotransplantation model to study the diverse immunologic and hemodynamic consequences that follow xenotransplantation and hyperacute rejection. Methods: The animals were divided into two groups: the cobra venom factor and Gadolinium chloride treatment group (CVF+Gd group) (3 cases) and the control group (3 cases). The donor pig"s whole liver was harvested, and then the harvested pig"s whole liver was transplanted into a dog after the dog underwent left hepatectomy. After reperfusion of the graft, blood samples were taken 20, 40 and 60 minutes after reperfusion, and the liver, lung and kidney tissues were taken 1 hour after reperfusion. Results: In the control group, the grafts showed a patchy hypoperfused liver surface and it felt rubbery solid compared to the CVF+Gd group. The serum total protein, albumin, fibrinogen and platelets decreased abruptly and there were no significant differences between the two groups. The serum PT, PTT and FDP were increased in both groups and the CVF+Gd group showed a more obtuse slope than the control group. We could not find any intravascular pathologic changes on the microscopic findings of the graft. Only scant intravascular fibrin deposition was found. Hepatocellular vacuolization and sinusoidal dilatation were also found. There were patches of necrosis without any zonal distribution, intrasinusoidal neutrophil sequestration and interstitial hemorrhage. These findings were milder in the CVF+Gd group. Conclusion: The pig to canine partial auxiliary liver xenotransplantation model is feasible and it is a good model before starting to perform pig to primate liver xenotransplantation. In the CVF+Gd group, pathologic findings like patch hepatocyte necrosis etc. were less severe. As there were no corresponding vascular pathologic findings, these findings are not the direct effect of CVF and gadolinium treatment, and so other factors like Ischemiareperfusion injury should be considered.
고홍숙(Hong Sook Ko),이금선(Geum Seon Lee),블랜딜(Blendyl Saguan Tan Lee),박형근(Hyun Geun Park),유구용(Gu Young Yoo),임동술(Dong Sool Yim),정인경(In Kyung Jung),오세관(Sei Kwan Oh),정재훈(Jae Hoon Cheong) 대한약학회 2005 약학회지 Vol.49 No.4
Gardenia Jasminoides (GJ) is traditionally used for treatment of hepatic disease, insomnia, anxiety? and inflammatory disease. The aim of this study is to examine effects of GJ extract in response to stress. Animals of the normal group were not exposed to any stress and the control group were exposed to stress. The rats of the Ginseng and GJ supplementary group were orally administered once a day with 100 mg of red ginseng extract, 100 mg of GJ extract/kg body weight. The mice were given water containing 200 mg of red ginseng extract, 200 mg of GJ extract/100 ㎖ potable water. Animals were given supplements for 7 days without stress, and then were given supplements for 5 days with restraint and electroshock stress. After loading final stress, we examined stress related behavioral changes of experimental animals and measured the levels of blood corticosterone. GJ-supplementation partially blocked the stress effect on locomotion and elevated plus maze test in rats, and also partially blocked stress-induced behavioral changes such as freezing, burrowing, face-washing, smelling and rearing behavior in rats. The effect was almost equipotent to Ginseng's effect. GJ-supplementation didn't influence on fatigue related behavior or physical stress resistance. GJ-supplementation decreased the levels of blood corticosterone which is increased by stress in rats. These results suggest that GJ protects partially the living organism from stress attack and it has the potential to be used as a functional material to alleviate stress response.