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黃芩(황금) 발효 추출물이 LPS로 유발된 마우스대식세포에서 염증인자증가에 미치는 영향
양회정 ( Hoi Jeong Yang ),한효상 ( Hyo Sang Han ),이영종 ( Young Jong Lee ) 대한본초학회 2013 大韓本草學會誌 Vol.28 No.5
Objectives: This study aims at examining the immuno-modulating activity in the fermentative extract of the root of Scutellaria baicalensis Georgi (Scutellariae Radix) on the production of inflammatory mediator in LPS-stimulated RAW264.7 mouse macrophages. Method : Measurements were done for the influences on the cell viability, generation of hydrogen peroxide in cells and nitric oxide (NO) generation using the macrophage of mouse with the specimen SBS as the fermentative extract of Scutellariae Radix (SBS) with Saccharomyces cerevisiae STV89. Result: As a result of carrying out MTT assay to check the cellular toxicity of the fermentative extract of Scutellariae Radix, any excessive toxicity to the macrophage did not occur from treatments by concentration for SBS. SBS increased the generation of hydrogen peroxide in the macrophage. SBS suppressed the NO generated in macrophages and SBS concentration higher than 25 ㎍/mL significantly suppressed the increased NO generated in LPS-stimulated macrophages. SBS concentration higher than 25 ㎍/mL significantly suppressed the generation of IL-6, IL-10, IL-12p40 and MCP-1 in LPS-stimulated macrophages. Conclusion: Our findings indicate that SBS has an immuno-modulating activity in macrophage activation through suppressing the generation of inflammatory substances, NO, IL-6, IL-10, IL-12p40 and MCP-1.
양회정(HoeJeong Yang),정회옥(Hoi Ok Jeong) 연세대학교 동서문제연구원 2022 동서연구 Vol.34 No.4
본 연구는 제21대 국회에서 청년의원은 청년을 대표하고 있는지 분석하였다. 즉, 국회 내에서 청년의 기술적 대표성 증대가 실질적 대표성 증대로 이어지고 있는지를 확인해보고자 하였다. 이를 위해 제21대 국회 개원(2020년 5월 30일) 이후 2022년 8월 31일까지 발의된 총 275건의 청년 관련 법안을 전수조사하여 양적, 질적 분석을 동시에 진행하였다. 분석 결과, 청년의원일수록 대표 발의와 공동 발의 모두에서 청년 관련한 법안 발의를 많이 하는 것으로 나타났다. 또한, 진보정당 소속일수록, 선수가 낮을수록 청년 법안을 더 많이 공동 발의함을 확인할 수 있었다. 청년 법안에 대한 질적 분석 결과는 제21대 국회의원들은 일자리 분야(28.36%, 78건)와 정치 분야(23.63%, 65건)에서 중점적으로 청년을 실질적으로 대표하고자 했음을 보여주었다. 특히, 청년의원은 수적으로 소수이나, 비청년의원과 차별성을 갖는 법안 발의를 통해 청년의 정치적, 사회적, 문화적, 경제적 권리를 보장하고 청년집단을 실질적으로 대표하고자 노력하고 있음을 확인할 수 있었다. The purpose of this study is to analyze whether youth lawmakers represent young people in the 21st National Assembly. In other words, it was intended to check whether the increase in the nominal representation of young people in the National Assembly leads to an increase in substansive representation. To this end, a total of 275 youth-related bills proposed from the opening of the 21st National Assembly(May 30, 2020) to August 31, 2022 were thoroughly investigated with quantitative and qualitative analysis conducted simultaneously. As a result of the analysis, it was found that the younger members of the legislature are more likely to initiate youth-related bills. In addition, it was confirmed that party membership and seniority have impacts on bill initiation. The results of the qualitative analysis of the youth-related bills showed that the 21st National Assembly members wanted to effectively represent the youth, particularly focusing on the issues of job(28.36%, 78 cases) and politics(23.63%, 65 cases). Although the number of youth lawmakers is small, they were found to make efforts to guarantee the political, social, cultural, and economic rights of young people and to represent the youth group by proposing bills that are different from non-youth members.