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한방청열제의 $3{\alpha}-Hydroxysteroid$ dehydrogenase에 대한 억제효과
안중수,최승연,권용수,김창민,Ahn, Jung-Su,Choi, Seung-Youn,Kwon, Yong-Soo,Kim, Chang-Min 한국생약학회 1998 생약학회지 Vol.29 No.1
$3{\alpha}-Hydroxysteroid$ dehydrogenase $(3{\alpha}-HSD)$ is one of the main enzymes involved in the metabolism of the active androgen, dihydrotestosterone. The NAD(P)-linked $3{\alpha}-HSD$ of rat liver cytosol is powerfully inhibited by the non-steroidal anti-inflammatory drugs in rank-order of their therapeutic potency. This observation has now been developed into a rapid screen for predicting the potency of products that show anti-inflammatory effect. 52-Chinese Herbs that clear heat were screened by using this method.
안중수,권용수,김창민,Ahn, Jung-Su,Kwon, Yong-Soo,Kim, Chang-Min 한국생약학회 1999 생약학회지 Vol.30 No.3
Five compounds were isolated from the BuOH fraction of Polygonum bistorta (Polygonaceae). On the basis of spectral data, these compounds were established as caffeic acid, quercimeritrin, avicularin, gallic acid and protocatechuic acid. The inhibitory activies on $3{\alpha}-hydroxysteroid$ dehydrogenase $(3\;{\alpha}-HSD)$ of isolated compounds were compared. $IC_{50}$ value of isolated compounds were $133.57\;{\mu}g/ml\;(caffeic\;acid)$, $89.1\;{\mu}g/ml\;(quercimeritrin)$, $189.85\;{\mu}g/ml\;(avicularin)$, $140.69\;{\mu}g/ml\;(gallic\;acid)$ and $165.27\;{\mu}g/ml\;(protocatechuic\;acid)$ respectively. Although all compounds showed lower inhibition activities than BuOH fraction $(IC_{50}<50\;{\mu}g/ml)$ of Polygonum bistorta, it showed higher inhibition activities than aspirin $(IC_{50}\;246.81\;{\mu}g/ml)$.
柳基漢,安重守 忠州大學校 1985 한국교통대학교 논문집 Vol.18 No.2
This paper studied on the efficient of audiovisual education stressed on soft ware to attain the purposed effect by using the audiovisual aids given. We presented some suggestions to improve the efficiency of information communication : the techniques of audiovisual education, the effects of teaching stick and cue, manufacturing OHP materials and the best ways of their practical use, the effective preparation and presentation of patterns, the better ways of VTR utilization and photographing, and the better utilization of Analyser and analysis of its records. We tried to solve the problems of audiovisual education methods by comparing and examining their characteristics. For an efficient education we need to develop the techniques of audiovisual education with psychological consideration. In this sense, the informations of audiovisual methods furnished in quantities should be analyzed and examined to improve the audiovisual education, and a continuous study and zeal should be followed to attain the purposed effect.