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안원근(An Won Geun),정태희(Jung Tae Hee),박한영(Park Han Yung),김한일(Kim Han Il),이동근(Lee Dong Keun) 한국유체기계학회 2006 유체기계 연구개발 발표회 논문집 Vol.- No.-
This Study has developed the water-hammer reducing system, when a pumping facility power cut. We have developed linear control or pressure constraint control method of butterfly valve. As a result, This system was performed control accuracy within ±3 percent. and then valve is full closed to keep up the uniform pressure. We are expected that this system is replaced by check valve. We hope this system is going to substitute for the air chamber or the surge tank.
Induction of Apoptosis by Vitamin E Succinate in Human Erythroleukemia K562 Cells
장창덕,김종명,안원근,박혜련,Jang, Chang-Deug,Kim, Jong-Myoung,An, Won-Geun,Park, Hye-Ryoun Korean Society of Life Science 2007 생명과학회지 Vol.17 No.7
비타민 E 유도체인 $RRR-{\alpha}-tocopheryl$ succinate (vitamin E succinate, VES)는 만성골수성 백혈병 세포인 K562세포에서 apoptosis를 유도하였다. VES의 처리에 의해 apoptosis가 유도되는 과정에서 K562 세포 내의 ROS의 생성이 증가되었으며, ROS와 관련된$NF-{\kappa}B$, COX-2 그리고 $p21^{WAF1/CIP1}$등의 유전자가 활성화되었다. 뿐만 아니라, apoptosis의 과정 중 중요한 역할을 하는 Bax의 발현증가 및 손상된 DNA의 회복에 중심적 기능을 하는 PARP의 분열이 야기되었다. VES를 처리한 세포의 세포주기 분석에서는 apoptotic phase인 sub-Gl phase에서 세포사멸이 증가되고, 형태적으로는 염색질의 응축이 일어나는 결과로 미루어볼 때 VES는 K562세포의 apoptosis를 유도한 것을 알 수 있다. C57BL/C의 림프종 이종이식을 통한 VES의 항암활성 실험 결과, C57BL/C의 대조군에 비하여 종양의 성장억제를 확인하였으며 높은 생존율을 확인하였다. 이러한 결과는 백혈병 치료에 대한 분자적 기초를 제공하였으며 동물실험을 통하여 보다 실질적인 백혈병 치료의 가능성을 보여주었다. Regulation mechanism of apoptosis has been known to be important for understanding the pathogenesis of a number of human diseases including cancers. The effects of $RRR-{\alpha}-tocopheryl$ succinate(vitamin E succinate, VES) on the cell viability, generation of ROS, expression of proteins involved in apoptosis, and growth of human chronic myelogenous leukemia K562 cells were analyzed in this study. VES treatment not only induced the generation of the ROS but also increased the levels of $NF-{\kappa}B$, COX-2, and $p21^{WAF1/CIP1}$ in K562 cells. It modulates the levels of pro-apoptotic proteins such as Bax provoking the apoptosis in K562 cells. The cleavage of PARP into 89 kDa was also increased upon VES treatment in a dosage-dependent manner. Induction of an apoptosis was evident by the increase of sub-Gl peak and cell shrinkage condensed chromatin in K562 cells treated with VES. It also resulted in an inhibition of tumor growth by 50% and prolonged survival of the Iymphoma-induced mice. This potentiation of VES obtained in vitro and in vivo may indicate the feasibility of more effective chemotherapy in chronic myelogenous leukemia.
곽재수(Jae Su Kwak),안원근(Won Geun An),김형모(Hyung Mo Kim),박영일(Young Il Park),양수석(Soo Seok Yang) 대한기계학회 2005 대한기계학회 춘추학술대회 Vol.2005 No.5
Performance tests of the plate-fin type heat exchanger for high temperature application have been performed with a high temperature heat exchanger performance test facility. The facility consists of air compressor, electric heaters, venturi flow meters, flow control valves, and combination probes which can measure temperature, total and static pressures at the same time. The performance tests were carried out near the heat exchanger design condition and off-design conditions, and the test results were compared with the calculated results. The test results showed lower heat exchanging efficiency and smaller pressure drop than the calculated results. Based on the difference, the modified design of the heat exchanger was offered.