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심창구(Chang-Koo Shim),김진웅(Jinwoong Kim) 大韓藥學會 2015 약학회지 Vol.59 No.2
The spring convention of the Pharmaceutical Society of Korea (PSK), composed of eight symposia and two special symposia, was held at the K Seoul Hotel on April 17th and 18th in 2014. During the convention, the board meeting of PSK officially approved the birth of Pharmacy History (PH) Division as one of 19 divisions of PSK on April 17th. In the morning of April 18th, an inaugural symposium of PH division was held at the hotel with a theme of "History of Pharmacy in Korea”. In this article, the establishment of PH division, content of the 1st symposium will be described. The future vision of PH division, which will be focused on the study of modern history rather than that of old history, will be described as well. The introduction of modern pharmacy education system to Korea and various events that happened during the establishment of the system may represent issues that should be investigated with the highest priority by the PH division.
효소 소화성 하이드로겔 정제의 팽윤 및 프록시필린 방출 특성
심창구(Chang Koo Shim),이영미(Young Mee Lee),여소현(So Hyeon Yeo) 대한약학회 1992 약학회지 Vol.36 No.3
Although oral route is the most convenient route for drug administration, the short and variable transit of drug through GI tract restricts the sustained drug absorption after oral administration. Thus, for sustained absorption of drugs, it is desirable to prolong the GI transit time by retaining the dosage forms in the stomach. In this study, the enzyme-digestible swelling hydrogel was synthesized by heating the mixed solution of N-vinyl-2-pyrrolidone[monomerl, acrylated albumin[crosslinking agent] and proxyphylline[drug] at 65oC for 10 hours in the cylindrical test tube. The resultant hydrogel tablet (diameter; 0.77cm, thickness; 0.47cm) was designed to swell in the gastric fluid after oral administration to such a size that passing through the pylorus could be inhibited during the drug release. After releasing drug, the hydrogel was expected to be degraded by pepsin, an enzyme in the stomach, and eventually solubilized. Actually, the hydrogel synthesized in the study swelled to a size larger than the diameter of the pylorus (1.3 +/- 0.7cm) and slowly digested in the presence of pepsin. Drug release from the hydrogel was prolonged up to about 12 hours. The swelling kinetics was dependent on albumin acrylation time, drug content and gel thickness. Particularly the gel thickness was the most important factor that influences on drug release. By adjusting these factors, the albumin-crosslinked hydrogel was expected to be retained in the stomach for up to 60 hours and used as a potential platform of drugs for long-term GI absorption.
감마선 조사법으로 합성한 PVP하이드로겔의 팽윤과 약물방출특성
심창구(Chang Koo Shim),오정숙(Chung Sook Oh),신병철(Byung Chul Shin) 대한약학회 1993 약학회지 Vol.37 No.5
The short and variable transit of drug throught GI tract and the inter-and intra-subject variations of the transit restrict the sustained drug absorption after oral adminstration. These restrictions may be solved by retaining the dosage forms in the stomach. Then the dosage form will act as a platform which releases the drug slowly and makes the GI absorption occur for a long time. In this study, as the platforms, PVP hydrogels were synthesized by chemical and gammar-irradiation method in the cylindrical test tube. The chemical method means the synthesis of the hydrogel by heating the mixed solution of N-vinyl-2-pyrrolidone [monomer], acrylated albumin [crosslinking agent], 2,2''-agobis(2-methylpropionitrile) [initiator] and proxyphylline [drug] at 65oC for 5 hr. The gammar-irradiation method means the synthesis of the hydrogel by irradiation with 60Co gammar-ray of the mixed solution of the monomer, acrylated albumin, and flurbiprofen [drug] at room temperature with total 0.2Mrad for 3 hr. Our intention is to design the hydrogel tablet (diameter : 1.20cm, thickness : 0.60cm) which swells in the gastric fluid after oral administration to such a size that passing through the pylorus could be inhibited during the period of drug release. After releasing drug, the hydrogel should be degraded by the enzymeatic digestion in the stomach, or by hydrolysis and eventually solubilized. Thus, in vitro tests were performed to examine the factors that affect swelling and drug release from the PVP hydrogels. Experimental results show that the hydrogels swell to a size larger than the diameter of the pylorus(1.3 +/- 0.7cm) and the hydrogel prepared by the chemical method is digested by pepsin. But the hydrogel prepared by the gammar-irradiation method was not digested by the pepsin and just collapsed with time. Thus, the swelling of the hydrogel synthesized by gammar-irradiation was independent albumin acrylation time and pepsin concentration. But drug content and radiation dose affected the swelling and drug release kinetics of the hydrogel. Drug release from the hydrigels was prolonged up to about 24 hr. Therefore, it was concluded that by adjusting these factors, the albumin-crosslinked PVP hydrogel synthesized by gammar-irradiation method is expected to be retained in the stomach for up to 60 hr and be a potential platform of drugs for long-term GI absorption.