연령대별 여성의 심혈관질환 위험요인 및 유산소성 능력 비교 분석

심유진(Shim, Yoo-Jin),김아람(Kim, A-Ram),김규태(Kim, Kyu-Tae) 한국체육과학회 2017 한국체육과학회지 Vol.26 No.4

This study aims to compare and analyze the body composition, cardiovascular diseases risk factors and aerobic function of adolescent and middle aged women in order to prevent cardiovascular disease of adolescent and middle aged women. As the result of comparative analysis on body composition, abdominal fat ratio of middle aged women was 0.1kg higher than adolescent women which showed significant difference(p〈.05). However, the skeletal muscle mass(kg), body fat(kg), lean body mass(kg), BMI(kg/m²), body fat percentage(%), and basal metabolism did not show significant difference. As the result of comparative analysis on branchial-ankle pulse wave velocity and ABI, the risk factors of cardiovascular diseases, middle aged women had about 290.42(s/cm) higher right branchial-ankle pulse wave velocity, which showed significant difference(p〈.05). Also, middle aged women had about 283.8(s/cm) higher the left branchial-ankle pulse wave velocity, which showed significant difference(p〈.05). As the result of comparative analysis on aerobic function, middle aged women had about 177,75(m) lower than adolescent women, and showed significant difference(p〈.05). Likewise, when compared to adolescent women, middle aged women are exposed to cardiovascular disease risk factors such as rapid changes in body composition or decrease in aerobic function. Thus, it requires women to take care of health and maintain the condition since their adolescence, and need particular attention to maintain and improve the aerobic function which poses positive influence of cardiovascular system.

운동프로그램이 보조적 항암화학요법을 받는 대장암 환자의 신체조성 및 스트레스에 미치는 영향

심유진(Shim, Yoo-Jin),최승욱(Choi, Seung-Wook) 한국체육과학회 2019 한국체육과학회지 Vol.28 No.4

The purpose of this study is to develop an exercise program for those colon cancer patients by applying an exercise program to those colon cancer patients who undergo adjuvant chemotherapy and thereby making a comparative analysis on the changes to their body composition and stress. The comparison of the body composition before and after the auxiliary anticancer chemotherapy showed that the exercise group registered a significant increase of about 1.25㎏ in the bone size and the muscle mass (p<.05) and the non-exercise group registered an insignificant increase of about 1㎏ (p>.05), while the body fat percentage decreased by about 2.25%, an insignificant difference in the exercise group (p>.05). It significantly increased by about 3.95% in the non-exercise group (p<.01). The muscle mass significantly increased by about 1.9㎏ in the exercise group (p<.05) and significantly by about 1.68㎏ in the non-exercise group as well (p<.05). The body fat percentage increased significantly by about 1.93㎏ in the exercise group (p<.05) and significantly increased by about 1.78㎏ in the non-exercise group as well (p<.05). Visceral fat increased significantly by about 8.32㎠ (p<.05) and increased significantly by about 22.45㎠ in the non-exercise group (p<.05). The comparison showed that the stress before and after the adjuvant chemotherapy decreased significantly by about 2.34 points (p<.05) whereas it did not register a significant difference in the non-exercise group even though it increased by about 2.5 points (p>.05). The current study confirmed that those cancer patients who underwent therapy experienced physically and mentally positive effects, which is expected to decrease the relapse rate and improve the quality of life for cancer patients.

운동이 위암환자에게 미치는 영향에 관한 문헌적 고찰

심유진(Shim, Yoo-Jin),김규태(Kim, Kyu-Tae) 한국체육과학회 2019 한국체육과학회지 Vol.28 No.6

This study aims to prove effects of exercise on stomach cancer patients through literature review and provide basic materials for development of programs of systematic exercise. In the study of Na et el.(2001) that carried out an aerobic exercise program oriented to stomach cancer patients after operation, NK cells increased in the exercise group. In the study of Choi J ini et al.(2012), according to the result of an 8-week-long exercise program oriented to stomach cancer patients under oral chemotherapy after operation, patients showed positive effects in terms of fatigue and anxiety, and improvement in NK cells and quality of life. On the other hand, the study of Sohn Yun-seon(2013) that carried out an exercise program in the complex anaerobic-aerobic form oriented to early-stage stomach cancer patients demonstrated improvement in maximal oxygen uptake. In the study of Wiebke Jansen et al.(2014), the results of an exercise program in the complex anaerobic-aerobic form oriented to gastrointestinal cancer patients under the palliative chemotherapy showed decreased level of fatigue of patients and increased sleeping hours and augmented level of muscular strength in the anaerobic exercise group. The studies confirmed that application of exercise programs for stomach cancer patients gave positive influences on them in all stages; after the operation, during the treatment and after the treatment. However, there are a small number of studies regarding development of customized exercise programs for stomach cancer patients. It is estimated that the number of stomach cancer patients will increase even more in the future because the rate of stomach cancer is steadily on the rise and the relative survival rate is also increasing after operation and treatment. It is considered highly important to provide exercise-based management for patients, during the post-diagnosis cancer treatment process and after treatment.

항암화학요법 치료주기별 대장암환자의 신체조성 및 부작용 비교・분석

심유진(Shim, Yoo-Jin),김아람(Kim, A-Ram) 한국체육과학회 2020 한국체육과학회지 Vol.29 No.4

This study compared and analyzed body composition and side effects of colorectal cancer patients by chemotherapy treatment cycle. 13 colorectal cancer patients who need to undergo adjuvant chemotherapy in K University Hospital in G-gu, S-si were selected as the subject of this study. According to the result of comparing and analyzing body composition, there was no significant difference in weight(kg), skeletal muscle mass(kg), volume of body fat(kg), BMI, body fat percentage(%), and visceral fat, but weight(kg), volume of body fat(kg), BMI, body fat percentage(%), and visceral fat tended to increase in general during the chemotherapy treatment cycle. As a result of comparing and analyzing the degree of side effects, it was identified that the subjects experienced side effects as loss of appetite, nausea, stomatitis, vomiting, diarrhea, constipation, numbness in hands and feet, fatigue, and pain. It was identified that changes in body composition and various side effects appeared by chemotherapy treatment cycle. It would be necessary to maintain and improve body composition during the treatment cycle, and various studies on the development of customized exercise program that can alleviate cyclic side effect should be actively conducted.

운동프로그램이 항암화학요법을 받는 대장암환자에 미치는 영향

심유진(Shim, Yoo-Jin),이재영(Lee, Jae-Young),최승욱(Choi, Seung-Wook) 한국체육과학회 2016 한국체육과학회지 Vol.25 No.1

This study is intended to investigate the effects of physical exercises on the colon cancer patients under chemotherapy. To that end, a literature study was conducted through domestic and overseas data. The study was conducted under the following purposes. First, the study aims to shed light on the importance and effects of physical exercises on colon cancer patients. Second, the study aims to offer basic data for exercise programs targeting colon cancer patients who are under chemotherapy. The findings are as follows based on the literature study. It was confirmed that exercises improve the quality of life of colon cancer patients under chemotherapy. In fact, their muscular strength and aerobic capabilities are enhanced and their fatigue and insomnia are reduced. In conclusion, exercises are beneficial to cancer patients as the side effects of chemotherapy are reduced and physical functions are improved. As a result, exercises can improve the quality of life of cancer patients. Thus, follow-up studies should be conducted in the future based on the findings.

항암화학요법 중인 대장암 환자의 신체조성이 항암치료 기간 및 부작용에 미치는 영향

심유진(Shim, Yoo-Jin),김아람(Kim, A-Ram) 한국체육과학회 2020 한국체육과학회지 Vol.29 No.1

The purpose of this study is to analyze the effects of the body composition of colorectal cancer patients under adjuvant systemic chemotherapy on the duration of treatment and toxic side effects of chemotherapy to provide necessary data for effective treatment of colorectal cancer patients. METHODS: The subject patients with colorectal cancer who received adjuvant chemotherapy (N=24) were tested for body composition, duration of chemotherapy, and toxic side effects of anti-cancer drugs. RESULTS: The muscle m ass was -.442, which w as significantly associated with the delay of chemotherapy at the significance level 0.05. Lean mass was -.442, showing significance at .05 with the delay of chemotherapy, and skeletal muscle mass was -.455 which was significantly related with the delay of chemotherapy at the significance level 0.05. Body fat mass was 053, which was significantly associated with, Thrombocytopenia, anti-cancer drug toxic side effect, at significance level .01. BMI was .472, which was significantly related to Thrombocytopenia, an anti-cancer drug toxic side effect, at the level of .05. The body fat rate was .581 which was significantly related to Thrombocytopenia. CONCLUSIONS: Muscle mass, lean mass, and skeletal muscle mass were correlated with the delay of chemotherapy. Body fat mass, BMI and abdominal fat percentage were correlated with side effects of anticancer drug toxicity. This suggests the significance of body composition while in chemotherapy and improvement of body composition during the treatment seems to have a positive effect on the treatment of colorectal cancer patients.

ROCK 억제제를 통한 사람 치유두 조직 유래 단일 사람 유도만능줄기세포의 생존성 향상

심유진(Yoo-Jin Shim),강영훈(Young-Hoon Kang),김현지(Hyeon-Ji Kim),김미정(Mi-Jeong Kim),이현정(Hyeon-Jeong Lee),손영범(Young-Bum Son),이성호(Sung-Ho Lee),전병균(Byeong-Gyun Jeon) 한국생명과학회 2019 생명과학회지 Vol.29 No.8

이 연구는 단일 세포로 분리된 유도만능줄기세포(induced pluripotent stem cells, iPSCs)에 anoikis 세포사멸을 억제할 수 있는 Rho-associated protein kinase (ROCK)의 억제제를 처리하여 iPSCs의 세포 생존성을 향상하고자 하였다. Episomal plasmid 방법으로 확립된 iPSCs를 단일세포로 분리한 후, ROCK 억제제 Y-27632 dihydrochloride (Y-27632)를 0 uM, 0.5 uM, 1 uM, 2.5 uM, 5 uM, 7.5 uM 및 10 uM 농도별로 5주일 동안 각각 처리하였을 때, 5 uM 이상의 농도에서 세포의 생존율이 유의적으로 향상되었고, 10 uM의 Y-27632을 0일, 1일, 2일, 3일, 4일 및 5일 동안 처리하였을 때, Y-27632의 노출 기간이 길어질수록 세포의 생존율이 유의적으로 향상되는 것을 관찰하였다. 그러나, Y-27632의 노출 후, iPSCs의 형태학적 분화가 관찰되어 10 uM의 Y-27632에서 5일 동안 iPSCs 에 처리 한 후, 줄기세포학적인 특성을 비교 조사하였다. 우선, octamer-binding transcription factor 4 (OCT-4), homeobox protein NANOG (NONOG) 및 SRY-box 2 (SOX-2) 줄기세포 특이 유전자의 발현은 Y-27632를 처리한 실험군은 Y-27632를 처리하지 않은 대조군에서 서로 유의적인 차이를 나타내지 않았다. 또한, Y-27632를 처리한 실험군은 Y-27632를 처리하지 않은 대조군과 비교하여 telomerase 활성과 이것의 활성과 관련된 telomerase reverse transcriptase (TERT) 및 telomerase RNA component (TERC)의 유전자 발현에는 유의적인 차이가 없었다. 이상의 결과로 보아, iPSCs에 Y-27632를 처리하였을 때, iPSCs의 줄기세포의 특정을 유지하면서 anoikis에 의한 세포사멸을 감소시켜 세포 생존율이 증가한다는 것을 알 수 있었다. The aim of the present study was to improve the cell viability of human dental papilla derived single-induced pluripotent stem cells (iPSCs) using a Rho-associated protein kinase (ROCK) inhibitor, Y-27632. The iPSCs were produced using an episomal plasmid-based reprogramming method. After cell separation using trypsin, the iPSCs were treated with 0, 0.5, 1, 2.5, 5, 7.5, or 10 μM Y-27632 for 5 d. Cell viability increased significantly following the 5 μM Y-27632 treatment (p<0.05). When the iPSCs were exposed to medium containing 10 μM Y-27632 for 0, 1, 2, 3, 4, and 5 d, the cell viability rate increased significantly in accordance with the cell viability rate (p<0.05). To evaluate the effect of the Y-27632 treatment on stemness characteristics, the expression of stem cell-specific transcripts and telomerase activity were investigated in the iPSCs treated with 10 μM Y-27632 for 5 d. The expression levels of stem cell-specific transcripts, such as OCT-4, NONOG, and SOX-2, and telomerase activity were not significantly different in the iPSCs treated with 10 μM Y-27632 as compared with those of untreated control iPSCs (p>0.05). Taken together, the results demonstrated that cell viability can be improved by treatment with the ROCK inhibitor Y-27632, without losing iPSC stemness characteristics.

암과 운동에 관한 문헌적 고찰

심유진(Shim, Yoo-Jin),정승삼(Jung, Seung-Sam),김아람(Kim, A-Ram),최승욱(Choi, Seung-Wook) 한국체육과학회 2013 한국체육과학회지 Vol.22 No.6

The purpose of this study is to understand effects of physical exercise program on improvements in mental and physical function and the quality of life through a review of the literature, to provide information about the importance and benefits of exercise for cancer patients, and in order to offer basic data for the development of an exercise program to meet the physical needs of each patient. By taking into consideration the review of the domestic and international literatures, the following results were obtained: First, positive effects of physical exercise program on physical function of cancer patients were reported. Since physical exercise can improve physical function, such as cardiovascular endurance, muscular strength, flexibility, and aerobic capacity, and reduced fatigue and improved vitality in cancer patients were observed. In addition, physical activity and exercise have effects on improvements in physical and mental capabilities; they reduce patient distress, anxiety, depression, stress, confusion, and mistrust associated with the emotional mental health improvement that can contribute to improve the quality of life of cancer patients.

수중운동이 골관절염 환자에게 미치는 효과에 관한 문헌적 고찰

이수정(Lee, Soo-Jung),심유진(Shim, Yoo-Jin),최승욱(Choi, Seung-Wook) 한국체육과학회 2019 한국체육과학회지 Vol.28 No.3

The purpose of this study was to investigate the effect of aqua exercise on osteoarthritis management through each literature to provide information on the importance of exercise and its effect on osteoarthritis patients. Exercise therapy has been shown to reduce pain with fewer side effects and have the effect of increased muscle strength and decreased drug dependence, increased motor performance and decreased sense of helplessness. In osteoarthritis patients, the form of ground exercise can exacerbate joint pain. However, aqua exercise works simultaneously with muscular and skeletal disorders, balance and strength enhancement, and provides a less impact environment, enabling therapeutic activities to reduce fall stress, and exercising with proper strength while reducing weight load on each joint by buoyancy. Aqua exercise programs have been found to bring physical and mental functions, including physical composition, physical strength, pain and quality of life, to patients with osteoarthritis. As such, aqua exercise programs are reported to have a positive effect on osteoarthritis patients. It has been shown to play an important role in the management of osteoarthritis. Therefore, the guidelines for aqua exercise programs for osteoarthritis patients should be prepared and a systematic exercise program should be implemented based on them.

중년여성의 하지 근기능과 균형능력에 관한 연구

김아람(Kim, A-Ram),심유진(Shim, Yoo-Jin) 한국체육과학회 2016 한국체육과학회지 Vol.25 No.4

The purpose of this study is to understand condition of balance ability and various isokinetic muscular strengths of middle aged women. Firstly, for muscular peak torque, Nm, there were significant differences in 6 0 °/sec of r ight extensor muscle and left flexor muscles, 180°/sec of right extensor muscle and left extensor and flexor muscles, and 300°/sec of right extensor muscle and left and right flexor muscles. Body weight peak torque (peak torque %BW) had significant differences in 60°/sec of right extensor and flexor muscles, right extensor muscle and 180°/sec of right and left extensor and flexor muscles, and 300°/sec of right extensor and left extensor and flexor muscles. Secondly, according to results from the overall stability index measured to compare balance ability, there were significant declines in both of right and left muscles. Thirdly, according to the result from the analysis of variance of multiple regression, the independent variable, which is significantly influencing made an impact on the balance ability was 300°/sec of left extensor and this was influencing right side of balance ability and according to the result from multiple regression for left side balance ability, the independent variable significantly influencing was 300°/sec of left flexor muscle and 60°/sec of right flexor muscle. Based on the results from the study, it was found that middle aged women have weakened muscular strengths and it is suggested that muscle-endurance corresponded to 300°/sec can positively influence improvement of balance ability.