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폐암 환자에서 혈청 Intercellular Adhesion Molecule-1 농도의 변화와 예후와의 관계
신헌섭 ( Hun Sub Shin ),정찬희 ( Chan Hee Jung ),박현덕 ( Hyun Duk Park ),이승세 ( Seung Sei Lee ) 대한내과학회 2003 대한내과학회지 Vol.64 No.4
Background : Adhesion molecule is related to cell-cell interaction and inflammatory interaction. In addition, adhesive interactions between tumor cells and adjacent cells and/or extracellular matrix are important role in the complex process of tumor growt
생물학적 전환에 의한 Compound K가 강화된 Ginsenoside의 HHDPC와 HaCaT 세포 증식 효과
박상헌 ( Sang Hun Park ),양정은 ( Jung Eun Yang ),신헌섭 ( Heon Sub Shin ),이정민 ( Jung Min Lee ) 대한미용학회 2012 대한미용학회지 Vol.8 No.2
Ginsenosides have been regarded as the principal components responsible for the pharmacological and biological activities of ginseng. In this study, more than 100 strains of bacteria were isolated from 30 kinds of soil. The 32 strains of bacteria showing β-glucosidase activity were screened using a Esculin-R2A agar. In order to biotransformation of ginsenosides, β-glucosidase-positive bacteria were cultivated with protopanaxadiol (PPD) ginsenosides. Biotransformation of PPD into minor ginsenosides was confirmed by thin layer chromatography (TLC) 48 h after cultivation. THG 01 showing transformed minor ginsenosides in TLC was selected from soil and was revealed to belong to genus of Flavobacterium. Its crude enzyme could transform PPD into a mixture of minor ginsenosides (G-01), which contained compound K more than 50% in total ginsenosides in HPLC chromatogram. PPD treated at a concentration of 0.1μg/mL increased the proliferation of human hair dermal papilla (HHDPC) and human keratinocyte (HaCaT) cells by about 30%, compared with non-treated group. G-01 exerted more proliferative effect by about 50% than PPD. This result suggested that the mixture of minor ginsenosides and/or compound K formed by biotransformation may provokes the growth of hair by proliferative effect on HHDPC and HaCaT.
한국인에서 갑상선기능에 따른 지질 , hsCRP , 허리둔부비와 같은 심혈관질환의 위험인자의 변화
정찬희(Chan Hee Jung),성기철(Ki Chul Sung),신헌섭(Hun Sub Shin),이현영(Hyun Young Lhee),박승하(Seung Ha Park),이호철(Ho Chul Lee),이은정(Eun Jung Rhee),이원영(Won Young Lee),김범수(Bum Soo Kim),강진호(Jin Ho Kang),김선우(Sun Woo Kim) 대한내과학회 2002 대한내과학회지 Vol.63 No.3
Background : Thyroid abnormalities affect a considerable portion of the population. Overt hypothyroidism is associated with an elevated risk of cardiovascular disease and adverse changes in blood lipids. Subclinical hypothyroidism is also associated with an increase risk of cardiovascular disease. So we performed the study to investigate the prevalence of overt and subclinical thyroid disorders and their association between cardiovascular risk factors. Methods : This study was performed in 66,260 subjects (43,588 men, 22,672 women ; between 20∼80 years of age, mean age 41.5±9.6). Serum free thyroxine (FT4), thyroid stimulating hormone (TSH), total cholesterol, low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) were measured with RIA using commercial kits. High sensitivity C-reactive protein (hsCRP) were measured with nephelometry. Results : The prevalence of overt thyrotoxicosis, subclinical thyrotoxicosis, overt hypothyroidism and subclinical hypothyroidism was 5/1000 (334 subjects), 6.4/1000 (426 subjects), 1.6/1000 (108 subjects), 6.4/1000 (375 subjects) population. Mean plasma total cholesterol and LDL-C were elevated in overt hypothyroidism than normal (202.1 mg/dL and 121.8 mg/dL versus 197.1 mg/dL and 120.1 mg/dL)(p<0.05). Also in subclinical hypothyroidism, mean total cholesterol and LDL-C level were elevated compared to normal group (201.9 mg/dL and 123.7 mg/dL)(p=0.015, p=0.047). Waist-to-hip ratio (WHR) was lower in overt thyrotoxicosis and was higher in hypothyroidism. Conclusion : The prevalence of thyroid dysfunction was not significantly different from those of other countries. It was also age dependent and higher in women but it was lower than expected. Patients with hypothyroidism exhibit higher levels of waist-to-hip ratio as index of obesity. Patients with subclinical hypothyroidism exhibited increased levels of the atherogenic parameters (Total cholesterol, LDL-C). Therefore screening and treatment for subclinical hypothyroidism may be warranted due to the adverse effects on lipid metabolism.(Korean J Med 63:273-282, 2002)
궤양성 대장염 환자에서 5 - Aminosalicylic Acid 로 유발된 급성 췌장염
이현영(Hyun Young Lhee),김병익(Byung Ik Kim),유태우(Tae Woo Yoo),이호철(Ho Chul Lee),정찬희(Chan Hee Jung),신헌섭(Hun Sub Shin),박승하(Seung Ha Park),김정욱(Jung Uk Kim),조용균(Yong Kyun Cho),이준행(Jun Haeng Lee),박창영(Chang Young 대한소화기학회 2002 대한소화기학회지 Vol.40 No.4
Acute pancreatitis is a rare complication of 5-aminosalicylic acid (5-ASA) treatment. We recently experienced a case of acute pancreatitis secondary to 5-ASA in a patient with ulcerative colitis (UC). A 25-year-old man was admitted for bloody diarrhea and lower abdominal pain. Mesalazine was used under the diagnosis of ulcerative colitis, but the symptoms were not improved. After symptomatic improvement by steroid treatment, mesalazine was restarted for maintaining the remission. On the next day, he had a sudden severe epigastric pain with elevation of serum amylase and lipase levels. Drug- induced pancreatitis was suspected, and the mesalazine was discontinued. His abdominal pain disappeared, and his serum amylase and lipase levels returned to normal. After the administration of sulfasalazine, however, pancreatitis was relapsed. In conclusion, we suggest that drug-induced pancreatitis should be suspected in any patient who develops new abdominal pain while receiving 5-ASA. (Korean J Gastroenterol 2002; 40: 282-285)
한국 성인에서 Helicobacter pylori 감염 유병 상태 및 심혈관 질환 위험인자들과의 연관성
이은정 ( Eun Jung Rhee ),성기철 ( Ki Chul Sung ),김범수 ( Bum Soo Kim ),강진호 ( Jin Ho Kang ),이만호 ( Man Ho Lee ),박정로 ( Jung Ro Park ),박승하 ( Seung Ha Park ),서정열 ( Jung Yul Suh ),신헌섭 ( Hun Sub Shin ),이현영 ( Hyun Yo 대한내과학회 2002 대한내과학회지 Vol.63 No.5
Background : Chronic inflammation plays an important role in the pathophysiology of atherosclerosis. Among the many pathogens causing chronic inflammation, Helicobacter pylori is the major pathogen for gastric diseases in Korean people. The purpose of this study is to evaluate the prevalence of Helicobacter pylori infection and its association with cardiovascular risk factors in healthy Korean adults. Methods : In 32,998 healthy subjects, the proportion of seroposive subjects for H. pylori and its association with cardiovascular risk factors were evaluated in participants in health screening program. H. pylori infection status was tested with serum IgG antibody test with ELISA and blood pressure, body mass index, serum lipid profiles, hsCRP were tested. Results : 67% of participants were infected with H. pylori serologic test. Seropositivity was highest in age group of over sixty and male subjects tended to be more infected with H. pylori (p<0.05) except for twenties and fifties. After adjusting for age and sex, H. pylori seropositive group showed higher mean values for triglycerides and lower values for HDL (p<0.05). The mean values of other risk factors showed no significant differences between two groups (p>0.05). In multiple logistic regression models, adjusted by age, sex and other variables, total cholesterol was associated with H. pylori seropositivity (odds ratio 1.004, 95% confidence intervals 1.002.1.006, p<0.001) and HDL was inversely related with H. pylori independently (odds ratio 0.990, 95% confidence intervals 0.987.0.992, p<0.001). Age and sex was also positively associated with H. pylori (odds ratio for age 1.029, 95% confidence intervals 1.026.1.032, p<0.001, odds ratio for women to men 0.818, 95% confidence intervals 0.750.0.893, p<0.001). Conclusion : The results of this study is that H. pylori infection is prevalent in Korean adults and is independently correlated with cardiovascular risk factors such as total cholesterol and HDL in atherogenic way in healthy subjects. This may support the previous hypothesises that H. pylori might be one of the atherosclerotic pathogens. (Korean J Med 63:469-476, 2002) Key Words : Helicobacter pylori , Risk factors , Atherosclerosis